3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (P0ABZ4)

Identification
Name:3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
Synonyms:
  • KDO 8-P phosphatase
Gene Name:kdsC
Enzyme Class:
Biological Properties
General Function:Involved in 3-deoxy-manno-octulosonate-8-phosphatase activity
Specific Function:Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate
Cellular Location:Cytoplasmic
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Water + 1.03-Deoxy-D-manno-octulosonate 8-phosphate ↔ 1.03-Deoxy-D-manno-octulosonate + 1.0Phosphate
ReactionCard
SMPDB Reactions:
1.03-deoxy-D-manno-octulosonate 8-phosphate +1.0Thumb+1.0Thumb → 1.0Thumb+1.03-deoxy-D-manno-octulosonate+1.0Thumb
1.03-deoxy-D-manno-octulosonate 8-phosphate + 1.0Water + 1.03-Deoxy-D-manno-octulosonate 8-phosphate → 1.0Phosphate + 1.03-deoxy-D-manno-octulosonate + 1.03-Deoxy-D-manno-octulosonate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Water + 1.03-Deoxy-D-manno-octulosonate 8-phosphate ↔ 1.03-Deoxy-D-manno-octulosonate + 1.0Phosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.03-Deoxy-D-manno-octulosonate 8-phosphate + 1.0Water → 1.03-Deoxy-D-manno-octulosonate + 1.0Inorganic phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB200693-Deoxy-D-manno-octulosonateMetaboCard
ECMDB200683-Deoxy-D-manno-octulosonate 8-phosphateMetaboCard
ECMDB21380Inorganic phosphateMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
3-deoxy-manno-octulosonate-8-phosphatase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphatase activity
phosphoric ester hydrolase activity
Process
lipid biosynthetic process
lipid metabolic process
lipopolysaccharide biosynthetic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b3198
Gene OrientationClockwise
Centisome Percentage:71.99
Left Sequence End3340295
Right Sequence End3340861
Gene Sequence:
>567 bp
ATGAATATCACTGCTACTGTTCTTCTTGCGTTTGGTATGTCGATGGATGCATTTGCTGCA
TCAATCGGTAAAGGTGCCACCCTCCATAAACCGAAATTTTCTGAAGCATTGCGAACCGGC
CTTATTTTTGGTGCCGTCGAAACCCTGACGCCGCTGATCGGCTGGGGAATGGGCATGTTA
GCCAGCCGGTTTGTCCTTGAATGGAACCACTGGATTGCGTTTGTGCTGCTGATATTCCTC
GGCGGGCGAATGATTATTGAGGGTTTTCGTGGCGCAGATGATGAAGATGAAGAGCCGCGC
CGTCGACACGGTTTCTGGCTACTGGTAACCACCGCGATTGCCACCAGCCTGGATGCCATG
GCTGTGGGTGTTGGTCTTGCTTTCCTGCAGGTCAACATTATCGCGACCGCATTGGCCATT
GGTTGTGCAACCTTGATTATGTCAACATTAGGGATGATGGTTGGTCGCTTTATCGGCTCA
ATTATTGGGAAAAAAGCGGAAATTCTCGGCGGGCTGGTGCTGATCGGCATCGGCGTCCAG
ATCCTCTGGACGCACTTCCACGGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:188
Protein Molecular Weight:19997
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
MSKAGASLATCYGPVSADVIAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGY
GIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENV
AYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKL
DEAKGQSI
References
External Links:
ResourceLink
Uniprot ID:P0ABZ4
Uniprot Name:KDSC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675134
Ecogene ID:EG12804
Ecocyc:EG12804
ColiBase:b3198
Kegg Gene:b3198
EchoBASE ID:EB2656
CCDB:KDSC_ECOLI
BacMap:16131088
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Wu, J., Woodard, R. W. (2003). "Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase." J Biol Chem 278:18117-18123. Pubmed: 12639950