| Identification |
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| Name: | Endonuclease III |
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| Synonyms: | Not Available |
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| Gene Name: | nth |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | base-excision repair |
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| Specific Function: | DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| 4 iron, 4 sulfur cluster binding | | base-excision repair | | DNA binding | | DNA N-glycosylase activity | | DNA-(apurinic or apyrimidinic site) lyase activity | | metal ion binding |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >636
atgaataaagcaaaacgcctggagatcctcactcgcctgcgtgagaacaatcctcatccc
accaccgagcttaatttcagttcgccttttgaattgctgattgccgtactgctttccgct
caggcgaccgatgtcagtgttaataaggcgacggcgaaactctacccggtggcgaatacg
cctgcagcgatgcttgaactgggcgttgaaggggtgaaaacctatatcaaaacgattggg
ctttataacagcaaagcagaaaatatcatcaaaacctgccgtatcttgctggagcagcat
aatggcgaggttccggaagatcgtgctgcgcttgaagccctgcccggcgtaggtcgtaaa
acagccaacgtcgtattaaacactgcattcggctggccgactattgctgtcgacacgcac
attttccgcgtttgtaatcgtactcaatttgcgccggggaaaaacgtcgaacaggtagaa
gaaaagctactgaaagtggttccagcagagtttaaagtcgactgccaccattggttgatc
ctgcacgggcgttatacctgcattgcccgcaagccccgctgtggctcttgtattattgaa
gatctttgtgaatacaaagagaaagttgacatctga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 211 |
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| Protein Molecular Weight: | 23562 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2ABK |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Endonuclease III
MNKAKRLEILTRLRENNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANT
PAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQHNGEVPEDRAALEALPGVGRK
TANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEEKLLKVVPAEFKVDCHHWLI
LHGRYTCIARKPRCGSCIIEDLCEYKEKVDI |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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