tRNA pseudouridine synthase C (P0AA41)

Identification
Name:tRNA pseudouridine synthase C
Synonyms:
  • tRNA pseudouridylate synthase C
  • tRNA-uridine isomerase C
Gene Name:truC
Enzyme Class:
Biological Properties
General Function:Translation, ribosomal structure and biogenesis
Specific Function:Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs
Cellular Location:Cytoplasmic
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
binding
catalytic activity
intramolecular transferase activity
isomerase activity
nucleic acid binding
pseudouridine synthase activity
RNA binding
Process
cellular macromolecule metabolic process
macromolecule metabolic process
metabolic process
pseudouridine synthesis
RNA metabolic process
RNA modification
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>783 bp
ATGATCAGTTCATTATGGATCGCCAAAACGGGCCTTGACGCCCAGCAAACCAATATGGAC
GTCATTGCCAACAACCTGGCAAACGTCAGTACTAACGGTTTTAAGCGTCAGCGCGCGGTG
TTTGAAGATCTGCTTTATCAAACCATTCGCCAGCCGGGGGCACAGTCTTCCGAACAAACC
ACCTTACCCTCCGGATTACAAATCGGCACGGGGGTACGCCCGGTCGCCACTGAACGCTTA
CACAGCCAGGGAAACCTGTCGCAGACCAACAACAGCAAAGATGTCGCGATTAAAGGGCAG
GGCTTTTTCCAGGTGATGTTGCCAGATGGTTCATCAGCCTATACCCGTGACGGCTCTTTC
CAGGTGGATCAGAACGGGCAGCTGGTGACGGCTGGTGGTTTTCAGGTGCAGCCAGCGATC
ACCATTCCGGCGAATGCGTTAAGTATCACCATCGGTCGTGATGGCGTGGTCAGCGTAACC
CAACAAGGCCAGGCAGCTCCGGTTCAGGTTGGGCAGCTCAATCTCACCACCTTTATGAAT
GACACCGGGCTGGAGAGCATTGGCGAAAACCTCTACACCGAAACGCAATCCTCTGGTGCA
CCGAACGAAAGCACGCCGGGCCTGAACGGCGCGGGACTGCTGTATCAAGGGTATGTTGAA
ACGTCTAACGTCAACGTGGCGGAAGAACTGGTCAATATGATTCAGGTGCAACGCGCTTAC
GAAATCAACAGTAAAGCGGTGTCCACCACCGATCAGATGCTGCAAAAACTGACGCAACTC
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:260
Protein Molecular Weight:29666
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>tRNA pseudouridine synthase C
MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV
LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK
GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK
HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL
PENERVEFSAPSGQDGEISS
References
External Links:
ResourceLink
Uniprot ID:P0AA41
Uniprot Name:TRUC_ECOLI
GenBank Gene ID:U00096
Genebank Protein ID:1787318
CCDB:TRUC_ECOLI
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Del Campo, M., Kaya, Y., Ofengand, J. (2001). "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli." RNA 7:1603-1615. Pubmed: 11720289
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553