ECMDB

Identification

Name:

Nitrogen regulatory protein P-II 1

Synonyms:

Not Available

Gene Name:

glnB

Enzyme Class:

Not Available

Biological Properties

General Function:

transcription, DNA-templated

Specific Function:

P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Two-component system ec02020

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
enzyme regulator activity
identical protein binding
nucleotide binding
regulation of nitrogen utilization
regulation of transcription, DNA-templated
transcription, DNA-templated

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>339
atgaaaaagattgatgcgattataaaacccttcaagctggacgatgtccgcgaagcactg
gccgaagtcggtattaccggcatgacggtgaccgaagtgaaaggctttggtcgccagaaa
ggccataccgagctgtaccgcggcgcggagtatatggtggattttctgccgaaagtgaaa
attgagattgtcgtaccggacgacattgtcgatacctgtgtcgataccattattcgcacg
gcgcaaaccggcaaaatcggtgacggtaaaatcttcgtctttgacgtggcacgggtcatt
cgcatccgtaccggtgaagaggacgacgcggcaatttaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

112

Protein Molecular Weight:

12425

Protein Theoretical pI:

Not Available

PDB File:

1PIL

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Nitrogen regulatory protein P-II 1
MKKIDAIIKPFKLDDVREALAEVGITGMTVTEVKGFGRQKGHTELYRGAEYMVDFLPKVK
IEIVVPDDIVDTCVDTIIRTAQTGKIGDGKIFVFDVARVIRIRTGEEDDAAI

References

External Links:

Resource	Link
Uniprot ID:	P0A9Z1
Uniprot Name:	GLNB_ECOLI
PDB ID:	1PIL
CCDB:	GLNB_ECOLI

General Reference:

Not Available

Nitrogen regulatory protein P-II 1 (P0A9Z1)