| Identification |
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| Name: | Phosphate-specific transport system accessory protein PhoU |
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| Synonyms: | Not Available |
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| Gene Name: | phoU |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | regulation of cell growth |
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| Specific Function: | Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. Encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. In this role, it may bind, possibly as a chaperone, to PhoR, PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB, or inhibit formation of the PhoR-PhoB transitory complex. Is also part of complex networks important for bacterial virulence, tolerance to antibiotics and stress response. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cellular phosphate ion homeostasis | | cellular response to antibiotic | | cellular response to heat | | cellular response to pH | | cellular response to phosphate starvation | | cellular response to starvation | | cytoplasm | | extrinsic component of plasma membrane | | magnesium ion binding | | manganese ion binding | | negative regulation of gene expression | | negative regulation of ion transmembrane transporter activity | | negative regulation of phosphate metabolic process | | negative regulation of phosphate transmembrane transport | | pathogenesis | | phosphate ion transport | | protein homodimerization activity | | regulation of cell growth |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >726
atggacagtctcaatcttaataaacatatttccggccagttcaacgccgaactggaaagt
atccgcacgcaggtgatgaccatgggcggcatggtggagcagcagctttctgatgcaatc
accgcgatgcataaccaggacagcgatctggcgaagcgcgtcatcgaaggcgacaagaac
gtcaacatgatggaagtggcgatcgatgaagcctgcgtgcgcattatcgccaaacgtcag
ccgacggcgagcgacctgcgactggttatggtgatcagtaaaaccattgccgagctggag
cgtattggcgacgtggcggacaaaatctgccgtactgcgctggagaaattctcccagcag
catcagccgttgctggtaagtctggagtcgctgggccgtcataccatccagatgctgcac
gacgtgctggacgcgttcgcgcggatggacattgacgaagcggtacgtatttatcgtgaa
gataaaaaagtcgatcaggaatacgaaggtattgttcgtcaactgatgacctacatgatg
gaagattcgcgtaccattccgagcgtacttactgcgctgttctgcgcgcgttctatcgaa
cgtattggcgaccgctgccagaatatttgtgagtttatcttctactacgtgaaggggcag
gatttccgtcacgtcggtggcgatgagctggataaactgctggcggggaaagatagcgac
aaataa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 241 |
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| Protein Molecular Weight: | 27417 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Phosphate-specific transport system accessory protein PhoU
MDSLNLNKHISGQFNAELESIRTQVMTMGGMVEQQLSDAITAMHNQDSDLAKRVIEGDKN
VNMMEVAIDEACVRIIAKRQPTASDLRLVMVISKTIAELERIGDVADKICRTALEKFSQQ
HQPLLVSLESLGRHTIQMLHDVLDAFARMDIDEAVRIYREDKKVDQEYEGIVRQLMTYMM
EDSRTIPSVLTALFCARSIERIGDRCQNICEFIFYYVKGQDFRHVGGDELDKLLAGKDSD
K |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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