ECMDB

Identification

Name:

G/U mismatch-specific DNA glycosylase

Synonyms:

Not Available

Gene Name:

mug

Enzyme Class:

3.2.2.28

Biological Properties

General Function:

base-excision repair, AP site formation

Specific Function:

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Base excision repair eco03410

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
base-excision repair, AP site formation
cytoplasm
DNA binding
pyrimidine-specific mismatch base pair DNA N-glycosylase activity

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>507
atggttgaggatattttggctccagggttacgggtcgtgttttgcggtatcaaccctggg
ctttcatccgccgggactggttttccctttgctcatccggcaaatcgcttctggaaggtg
atatatcaggccgggtttaccgaccgtcagttgaagccgcaggaggcacagcatctgctg
gattatcgttgtggcgtcaccaaactggtagaccgtccaacggtgcaagccaatgaagtt
tcaaagcaggagctacacgcaggcgggcgtaagctgattgaaaaaattgaagattatcag
ccgcaggcgttggcgattctgggcaaacaagcatatgaacagggattcagccagcgcggt
gcacagtgggggaaacaaacgctcaccattggttcgacgcagatttgggtgctgccaaat
cccagcggtttaagtcgcgtttcactggagaaactggttgaagcgtatcgcgagctggac
caggcgctggtagtgcgtgggcgataa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

168

Protein Molecular Weight:

18673

Protein Theoretical pI:

Not Available

PDB File:

1MTL

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>G/U mismatch-specific DNA glycosylase
MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLL
DYRCGVTKLVDRPTVQANEVSKQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRG
AQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR

References

External Links:

Resource	Link
Uniprot ID:	P0A9H1
Uniprot Name:	MUG_ECOLI
PDB ID:	1MTL
CCDB:	MUG_ECOLI

General Reference:

Not Available

G/U mismatch-specific DNA glycosylase (P0A9H1)