| Identification |
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| Name: | G/U mismatch-specific DNA glycosylase |
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| Synonyms: | Not Available |
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| Gene Name: | mug |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | base-excision repair, AP site formation |
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| Specific Function: | Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| base-excision repair, AP site formation | | cytoplasm | | DNA binding | | pyrimidine-specific mismatch base pair DNA N-glycosylase activity |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >507
atggttgaggatattttggctccagggttacgggtcgtgttttgcggtatcaaccctggg
ctttcatccgccgggactggttttccctttgctcatccggcaaatcgcttctggaaggtg
atatatcaggccgggtttaccgaccgtcagttgaagccgcaggaggcacagcatctgctg
gattatcgttgtggcgtcaccaaactggtagaccgtccaacggtgcaagccaatgaagtt
tcaaagcaggagctacacgcaggcgggcgtaagctgattgaaaaaattgaagattatcag
ccgcaggcgttggcgattctgggcaaacaagcatatgaacagggattcagccagcgcggt
gcacagtgggggaaacaaacgctcaccattggttcgacgcagatttgggtgctgccaaat
cccagcggtttaagtcgcgtttcactggagaaactggttgaagcgtatcgcgagctggac
caggcgctggtagtgcgtgggcgataa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 168 |
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| Protein Molecular Weight: | 18673 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1MTL |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >G/U mismatch-specific DNA glycosylase
MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLL
DYRCGVTKLVDRPTVQANEVSKQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRG
AQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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