| Identification |
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| Name: | Transcriptional regulator ModE |
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| Synonyms: | Not Available |
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| Gene Name: | modE |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region, upstream of the modABC operon, which contains an 8-base inverted repeat 5'-TAACGTTA-3' flanked by two CAT boxes. Acts also as an enhancer of the expression of genes coding for molybdoenzymes, both directly and indirectly. ModE also interacts with tungstate. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| ATP binding | | ATP-binding cassette (ABC) transporter complex | | cytoplasm | | DNA binding | | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | | molybdate ion transmembrane transporter activity | | molybdenum ion binding | | sequence-specific DNA binding transcription factor activity | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >789
atgcaggccgaaatccttctcacccttaagctccaacaaaaattattcgccgacccgcgc
cgcatttcgctactaaaacacattgcgctttccggttccattagccagggagcgaaagat
gccggtattagctataaaagcgcctgggatgccattaacgagatgaatcagttaagtgag
catattctggtcgagcgcgcaacaggcggtaaaggtggcggcggcgcagtactgacccgc
tatggtcagcgactgattcagctctatgacttactggcgcaaatccagcaaaaagccttt
gatgtgttaagtgacgatgacgccctgccgctgaacagcctgctggccgcgatctcacgt
ttttcactgcaaaccagcgcccgtaaccagtggttcggtaccatcaccgcccgcgatcat
gatgacgttcaacagcatgttgatgtcttactggctgacggaaaaacacgcctgaaagtc
gcaattaccgcacaaagcggcgcgcgtctggggctggatgaaggcaaagaagtgttgata
ttgctaaaagcgccgtgggtaggtattactcaggacgaggcggtcgcgcaaaacgctgac
aaccaattaccgggtattattagtcatattgagcgcggcgcagagcagtgcgaagtatta
atggcgctacccgacgggcaaacactgtgcgccacagtgccggtaaatgaagcgacttct
cttcagcaaggacagaatgtcacggcctactttaatgccgacagcgtgattatcgccacg
ctgtgctaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 262 |
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| Protein Molecular Weight: | 28280 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1B9M |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Transcriptional regulator ModE
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNQLSE
HILVERATGGKGGGGAVLTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLNSLLAAISR
FSLQTSARNQWFGTITARDHDDVQQHVDVLLADGKTRLKVAITAQSGARLGLDEGKEVLI
LLKAPWVGITQDEAVAQNADNQLPGIISHIERGAEQCEVLMALPDGQTLCATVPVNEATS
LQQGQNVTAYFNADSVIIATLC |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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