Identification |
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Name: | Fatty acid metabolism regulator protein |
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Synonyms: | Not Available |
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Gene Name: | fadR |
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Enzyme Class: | Not Available |
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Biological Properties |
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General Function: | transcription, DNA-templated |
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Specific Function: | Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds. |
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Cellular Location: | Not Available |
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SMPDB Pathways: | Not Available |
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KEGG Pathways: | Not Available |
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Metabolites: | |
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GO Classification: | Function |
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cytoplasm | DNA binding | fatty acid oxidation | fatty-acyl-CoA binding | negative regulation of transcription, DNA-templated | positive regulation of fatty acid biosynthetic process | positive regulation of transcription, DNA-templated | regulation of fatty acid metabolic process | sequence-specific DNA binding transcription factor activity | transcription, DNA-templated |
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Gene Properties |
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Blattner: | Not Available |
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Gene Orientation | Not Available |
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Centisome Percentage: | Not Available |
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Left Sequence End | Not Available |
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Right Sequence End | Not Available |
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Gene Sequence: | >720
atggtcattaaggcgcaaagcccggcgggtttcgcggaagagtacattattgaaagtatc
tggaataaccgcttccctcccgggactattttgcccgcagaacgtgaactttcagaatta
attggcgtaacgcgtactacgttacgtgaagtgttacagcgtctggcacgagatggctgg
ttgaccattcaacatggcaagccgacgaaggtgaataatttctgggaaacttccggttta
aatatccttgaaacactggcgcgactggatcacgaaagtgtgccgcagcttattgataat
ttgctgtcggtgcgtaccaatatttccactatttttattcgcaccgcgtttcgtcagcat
cccgataaagcgcaggaagtgctggctaccgctaatgaagtggccgatcacgccgatgcc
tttgccgagctggattacaacatattccgcggcctggcgtttgcttccggcaacccgatt
tacggtctgattcttaacgggatgaaagggctgtatacgcgtattggtcgtcactatttc
gccaatccggaagcgcgcagtctggcgctgggcttctaccacaaactgtcggcgttgtgc
agtgaaggcgcgcacgatcaggtgtacgaaacagtgcgtcgctatgggcatgagagtggc
gagatttggcaccggatgcagaaaaatctgccgggtgatttagccattcaggggcgataa
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Protein Properties |
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Pfam Domain Function: | Not Available |
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Protein Residues: | 239 |
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Protein Molecular Weight: | 26968 |
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Protein Theoretical pI: | Not Available |
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PDB File: | 1E2X |
Signaling Regions: | Not Available |
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Transmembrane Regions: | Not Available |
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Protein Sequence: | >Fatty acid metabolism regulator protein
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGW
LTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQH
PDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYF
ANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR |
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References |
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External Links: | |
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General Reference: | Not Available |
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