Identification
Name:Fatty acid metabolism regulator protein
Synonyms:Not Available
Gene Name:fadR
Enzyme Class:Not Available
Biological Properties
General Function:transcription, DNA-templated
Specific Function:Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
cytoplasm
DNA binding
fatty acid oxidation
fatty-acyl-CoA binding
negative regulation of transcription, DNA-templated
positive regulation of fatty acid biosynthetic process
positive regulation of transcription, DNA-templated
regulation of fatty acid metabolic process
sequence-specific DNA binding transcription factor activity
transcription, DNA-templated
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>720
atggtcattaaggcgcaaagcccggcgggtttcgcggaagagtacattattgaaagtatc
tggaataaccgcttccctcccgggactattttgcccgcagaacgtgaactttcagaatta
attggcgtaacgcgtactacgttacgtgaagtgttacagcgtctggcacgagatggctgg
ttgaccattcaacatggcaagccgacgaaggtgaataatttctgggaaacttccggttta
aatatccttgaaacactggcgcgactggatcacgaaagtgtgccgcagcttattgataat
ttgctgtcggtgcgtaccaatatttccactatttttattcgcaccgcgtttcgtcagcat
cccgataaagcgcaggaagtgctggctaccgctaatgaagtggccgatcacgccgatgcc
tttgccgagctggattacaacatattccgcggcctggcgtttgcttccggcaacccgatt
tacggtctgattcttaacgggatgaaagggctgtatacgcgtattggtcgtcactatttc
gccaatccggaagcgcgcagtctggcgctgggcttctaccacaaactgtcggcgttgtgc
agtgaaggcgcgcacgatcaggtgtacgaaacagtgcgtcgctatgggcatgagagtggc
gagatttggcaccggatgcagaaaaatctgccgggtgatttagccattcaggggcgataa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:239
Protein Molecular Weight:26968
Protein Theoretical pI:Not Available
PDB File:1E2X
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Fatty acid metabolism regulator protein
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGW
LTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQH
PDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYF
ANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR
References
External Links:
ResourceLink
Uniprot ID:P0A8V6
Uniprot Name:FADR_ECOLI
PDB ID:1E2X
CCDB:FADR_ECOLI
General Reference:Not Available