ECMDB

Identification

Name:

Fatty acid metabolism regulator protein

Synonyms:

Not Available

Gene Name:

fadR

Enzyme Class:

Not Available

Biological Properties

General Function:

transcription, DNA-templated

Specific Function:

Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
cytoplasm
DNA binding
fatty acid oxidation
fatty-acyl-CoA binding
negative regulation of transcription, DNA-templated
positive regulation of fatty acid biosynthetic process
positive regulation of transcription, DNA-templated
regulation of fatty acid metabolic process
sequence-specific DNA binding transcription factor activity
transcription, DNA-templated

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>720
atggtcattaaggcgcaaagcccggcgggtttcgcggaagagtacattattgaaagtatc
tggaataaccgcttccctcccgggactattttgcccgcagaacgtgaactttcagaatta
attggcgtaacgcgtactacgttacgtgaagtgttacagcgtctggcacgagatggctgg
ttgaccattcaacatggcaagccgacgaaggtgaataatttctgggaaacttccggttta
aatatccttgaaacactggcgcgactggatcacgaaagtgtgccgcagcttattgataat
ttgctgtcggtgcgtaccaatatttccactatttttattcgcaccgcgtttcgtcagcat
cccgataaagcgcaggaagtgctggctaccgctaatgaagtggccgatcacgccgatgcc
tttgccgagctggattacaacatattccgcggcctggcgtttgcttccggcaacccgatt
tacggtctgattcttaacgggatgaaagggctgtatacgcgtattggtcgtcactatttc
gccaatccggaagcgcgcagtctggcgctgggcttctaccacaaactgtcggcgttgtgc
agtgaaggcgcgcacgatcaggtgtacgaaacagtgcgtcgctatgggcatgagagtggc
gagatttggcaccggatgcagaaaaatctgccgggtgatttagccattcaggggcgataa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

239

Protein Molecular Weight:

26968

Protein Theoretical pI:

Not Available

PDB File:

1E2X

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Fatty acid metabolism regulator protein
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGW
LTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQH
PDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYF
ANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR

References

External Links:

Resource	Link
Uniprot ID:	P0A8V6
Uniprot Name:	FADR_ECOLI
PDB ID:	1E2X
CCDB:	FADR_ECOLI

General Reference:

Not Available

Fatty acid metabolism regulator protein (P0A8V6)