Thiol peroxidase (P0A862)

Identification
Name:Thiol peroxidase
Synonyms:
  • Scavengase P20
Gene Name:tpx
Enzyme Class:
Biological Properties
General Function:Involved in oxidoreductase activity, acting on peroxide as acceptor
Specific Function:Has antioxidant activity. Could remove peroxides or H(2)O(2) within the catalase- and peroxidase-deficient periplasmic space
Cellular Location:Periplasm
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
2.0Thiol-containing reductant+1.0ROOH ↔ 1.0Oxidized thiol-containing reductant+1.0Thumb+1.0ROH
2.0Thiol-containing reductant + 1.0ROOH ↔ 1.0Oxidized thiol-containing reductant + 1.0Water + 1.0ROH
ReactionCard
Metabolites:
ECMDB IDNameView
GO Classification:
Function
antioxidant activity
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on peroxide as acceptor
peroxidase activity
thioredoxin peroxidase activity
Process
cell redox homeostasis
cellular homeostasis
cellular process
metabolic process
oxidation reduction
Gene Properties
Blattner:b1324
Gene OrientationCounterclockwise
Centisome Percentage:29.88
Left Sequence End1386329
Right Sequence End1386835
Gene Sequence:
>507 bp
ATGTCACAAACCGTTCATTTCCAGGGCAACCCGGTTACAGTCGCCAATTCCATCCCGCAG
GCGGGTAGCAAAGCGCAGACTTTTACTCTCGTGGCAAAAGATCTGTCTGACGTCACCCTC
GGTCAGTTTGCGGGTAAACGCAAAGTGCTGAACATTTTCCCGAGTATTGATACCGGTGTT
TGCGCCGCATCAGTACGTAAGTTTAACCAACTGGCAACTGAGATCGACAACACCGTTGTG
CTGTGTATCTCTGCCGATCTGCCGTTCGCCCAGTCTCGTTTCTGCGGCGCAGAAGGTCTG
AACAACGTTATCACCCTCTCCACTTTCCGTAACGCTGAATTTCTGCAAGCTTACGGTGTG
GCAATTGCTGATGGCCCACTGAAAGGTCTGGCAGCGCGTGCCGTTGTGGTTATTGACGAA
AATGACAATGTGATTTTCAGCCAGCTGGTGGATGAAATCACCACCGAGCCGGATTACGAA
GCAGCTCTGGCTGTACTGAAAGCATAA
Protein Properties
Pfam Domain Function:
Protein Residues:168
Protein Molecular Weight:17835
Protein Theoretical pI:5
PDB File:1QXH
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Thiol peroxidase
MSQTVHFQGNPVTVANSIPQAGSKAQTFTLVAKDLSDVTLGQFAGKRKVLNIFPSIDTGV
CAASVRKFNQLATEIDNTVVLCISADLPFAQSRFCGAEGLNNVITLSTFRNAEFLQAYGV
AIADGPLKGLAARAVVVIDENDNVIFSQLVDEITTEPDYEAALAVLKA
References
External Links:
ResourceLink
Uniprot ID:P0A862
Uniprot Name:TPX_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674905
PDB ID:1QXH
Ecogene ID:EG12672
Ecocyc:EG12672
ColiBase:b1324
Kegg Gene:b1324
EchoBASE ID:EB2538
CCDB:TPX_ECOLI
BacMap:16129285
General Reference:
  • Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Cha, M. K., Kim, H. K., Kim, I. H. (1995). "Thioredoxin-linked "thiol peroxidase" from periplasmic space of Escherichia coli." J Biol Chem 270:28635-28641. Pubmed: 7499381
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646