DNA-directed RNA polymerase subunit omega (P0A800)

Identification
Name:DNA-directed RNA polymerase subunit omega
Synonyms:
  • RNAP omega subunit
  • RNA polymerase omega subunit
  • Transcriptase subunit omega
Gene Name:rpoZ
Enzyme Class:
Biological Properties
General Function:Involved in DNA-directed RNA polymerase activity
Specific Function:Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
Cellular Location:Cytoplasmic
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0RNA+1.0RNA ↔ 1.0Thumb+1.0RNA
1.0Adenosine triphosphate + 1.0RNA + 1.0RNA ↔ 1.0Pyrophosphate + 1.0RNA
ReactionCard
1.0Thumb+1.0RNA ↔ 1.0Thumb+1.0RNA
1.0Guanosine triphosphate + 1.0RNA ↔ 1.0Pyrophosphate + 1.0RNA
ReactionCard
1.0Thumb+1.0RNA ↔ 1.0Thumb+1.0RNA
1.0Cytidine triphosphate + 1.0RNA ↔ 1.0Pyrophosphate + 1.0RNA
ReactionCard
1.0Thumb+1.0RNA ↔ 1.0Thumb+1.0RNA
1.0Uridine triphosphate + 1.0RNA ↔ 1.0Pyrophosphate + 1.0RNA
ReactionCard
1.0Nucleoside triphosphate+1.0RNA ↔ 1.0Thumb
1.0Nucleoside triphosphate + 1.0RNA ↔ 1.0Pyrophosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB00082Cytidine triphosphateMetaboCard
ECMDB01273Guanosine triphosphateMetaboCard
ECMDB04142PyrophosphateMetaboCard
ECMDB00285Uridine triphosphateMetaboCard
GO Classification:
Function
binding
catalytic activity
DNA binding
DNA-directed RNA polymerase activity
nucleic acid binding
nucleotidyltransferase activity
RNA polymerase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
metabolic process
transcription
transcription, DNA-dependent
Gene Properties
Blattner:b3649
Gene OrientationClockwise
Centisome Percentage:82.34
Left Sequence End3820129
Right Sequence End3820404
Gene Sequence:
>276 bp
ATGAAAATAATCTCTAAAATGTTAGTCGGTGCGTTAGCGTTAGCCGTTACCAATGTCTAT
GCCGCTGAATTGATGACCAAAGCGGAATTTGAAAAAGTTGAATCGCAGTATGAAAAAATA
GGTGATATTTCAACCAGCAATGAAATGTCGACTGCAGATGCAAAAGAAGATTTGATCAAA
AAAGCGGATGAAAAAGGGGCTGATGTGTTGGTACTGACCTCCGGTCAAACTGACAATAAG
ATCCACGGCACGGCAAATATTTATAAGAAGAAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:91
Protein Molecular Weight:10237
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>DNA-directed RNA polymerase subunit omega
MARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLIN
NQILDVRERQEQQEQEAAELQAVTAIAEGRR
References
External Links:
ResourceLink
Uniprot ID:P0A800
Uniprot Name:RPOZ_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674472
Ecogene ID:EG10899
Ecocyc:EG10899
ColiBase:b3649
Kegg Gene:b3649
EchoBASE ID:EB0892
CCDB:RPOZ_ECOLI
BacMap:16131520
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Daniels, D. L., Blattner, F. R. (1993). "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Genomics 16:551-561. Pubmed: 7686882
  • Gentry, D. R., Burgess, R. R. (1986). "The cloning and sequence of the gene encoding the omega subunit of Escherichia coli RNA polymerase." Gene 48:33-40. Pubmed: 3549461
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Sarubbi, E., Rudd, K. E., Xiao, H., Ikehara, K., Kalman, M., Cashel, M. (1989). "Characterization of the spoT gene of Escherichia coli." J Biol Chem 264:15074-15082. Pubmed: 2549050