Identification
Name:Ribonuclease P protein component
Synonyms:Not Available
Gene Name:rnpA
Enzyme Class:
Biological Properties
General Function:tRNA processing
Specific Function:RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
ribonuclease P activity
RNA phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA processing
tRNA 5'-leader removal
tRNA binding
tRNA processing
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>360
gtggttaagctcgcatttcccagggagttacgcttgttaactcccagtcaattcacattc
gtcttccagcagccacaacgggctggcacgccgcaaattaccattctcggccgcctgaat
tcgctggggcatccccgtatcggtcttacagtcgccaagaaaaacgttcgacgcgcccat
gaacgcaatcggattaaacgtctgacgcgtgaaagcttccgtctgcgccaacatgaactc
ccggctatggatttcgtggtggtggcgaaaaaaggggttgccgacctcgataaccgtgct
ctctcggaagcgttggaaaaattatggcgccgccactgtcgcctggctcgcgggtcctga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:119
Protein Molecular Weight:13789
Protein Theoretical pI:Not Available
PDB File:2LJP
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Ribonuclease P protein component
MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAH
ERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS
References
External Links:
ResourceLink
Uniprot ID:P0A7Y8
Uniprot Name:RNPA_ECOLI
PDB ID:2LJP
CCDB:RNPA_ECOLI
General Reference:Not Available