ECMDB

Identification

Name:

50S ribosomal protein L1

Synonyms:

Not Available

Gene Name:

rplA

Enzyme Class:

Not Available

Biological Properties

General Function:

translation

Specific Function:

One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk. It is often not seen in high-resolution crystal structures, but can be seen in cryo_EM and 3D reconstruction models. These indicate that the distal end of the stalk moves by approximately 20 angstroms (PubMed:12859903). This stalk movement is thought to be coupled to movement of deacylated tRNA into and out of the E site, and thus to participate in tRNA translocation (PubMed:12859903). Contacts the P and E site tRNAs.Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Ribosome eco03010

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
cytosolic large ribosomal subunit
negative regulation of translational initiation
rRNA binding
structural constituent of ribosome
translation
tRNA binding

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>705
atggctaaactgaccaagcgcatgcgtgttatccgcgagaaagttgatgcaaccaaacag
tacgacatcaacgaagctatcgcactgctgaaagagctggcgactgctaaattcgtagaa
agcgtggacgtagctgttaacctcggcatcgacgctcgtaaatctgaccagaacgtacgt
ggtgcaactgtactgccgcacggtactggccgttccgttcgcgtagccgtatttacccaa
ggtgcaaacgctgaagctgctaaagctgcaggcgcagaactggtaggtatggaagatctg
gctgaccagatcaagaaaggcgaaatgaactttgacgttgttattgcttctccggatgca
atgcgcgttgttggccagctgggccaggttctgggtccgcgcggcctgatgccaaacccg
aaagtgggtactgtaacaccgaacgttgctgaagcggttaaaaacgctaaagctggccag
gttcgttaccgtaacgacaaaaacggcatcatccacaccaccatcggtaaagtggacttt
gacgctgacaaactgaaagaaaacctggaagctctgctggttgcgctgaaaaaagcaaaa
ccgactcaggcgaaaggcgtgtacatcaagaaagttagcatctccaccaccatgggtgca
ggtgttgcagttgaccaggctggcctgagcgcttctgtaaactaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

234

Protein Molecular Weight:

24729

Protein Theoretical pI:

Not Available

PDB File:

1EG0

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>50S ribosomal protein L1
MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVR
GATVLPHGTGRSVRVAVFTQGANAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDA
MRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDF
DADKLKENLEALLVALKKAKPTQAKGVYIKKVSISTTMGAGVAVDQAGLSASVN

References

External Links:

Resource	Link
Uniprot ID:	P0A7L0
Uniprot Name:	RL1_ECOLI
PDB ID:	1EG0
CCDB:	RL1_ECOLI

General Reference:

Not Available

50S ribosomal protein L1 (P0A7L0)