ECMDB

Identification

Name:

50S ribosomal protein L7/L12

Synonyms:

Not Available

Gene Name:

rplL

Enzyme Class:

Not Available

Biological Properties

General Function:

translation

Specific Function:

The binding site for several of the GTPase factors involved in protein synthesis (IF-2, EF-Tu, EF-G and RF3). Is thus essential for accurate translation. Deletion of 1 of the L12 dimers from the ribosome (by deleting the binding site on L10) leads to decreased IF-2 association with the 70S ribosome and decreased stimulation of the GTPase activity of EF-G.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Ribosome eco03010

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
cytosolic large ribosomal subunit
structural constituent of ribosome
translation

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>366
atgtctatcactaaagatcaaatcattgaagcagttgcagctatgtctgtaatggacgtt
gtagaactgatctctgcaatggaagaaaaattcggtgtttccgctgctgctgctgtagct
gtagctgctggcccggttgaagctgctgaagaaaaaactgaattcgacgtaattctgaaa
gctgctggcgctaacaaagttgctgttatcaaagcagtacgtggcgcaactggcctgggt
ctgaaagaagctaaagacctggtagaatctgcaccggctgctctgaaagaaggcgtgagc
aaagacgacgcagaagcactgaaaaaagctctggaagaagctggcgctgaagttgaagtt
aaataa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

121

Protein Molecular Weight:

12295

Protein Theoretical pI:

Not Available

PDB File:

1CTF

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>50S ribosomal protein L7/L12
MSITKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILK
AAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEV
K

References

External Links:

Resource	Link
Uniprot ID:	P0A7K2
Uniprot Name:	RL7_ECOLI
PDB ID:	1CTF
CCDB:	RL7_ECOLI

General Reference:

Not Available

50S ribosomal protein L7/L12 (P0A7K2)