| Identification |
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| Name: | LexA repressor |
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| Synonyms: | Not Available |
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| Gene Name: | lexA |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352). |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cellular response to DNA damage stimulus | | DNA binding | | DNA repair | | DNA replication | | negative regulation of transcription, DNA-templated | | serine-type endopeptidase activity | | SOS response | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >609
atgaaagcgttaacggccaggcaacaagaggtgtttgatctcatccgtgatcacatcagc
cagacaggtatgccgccgacgcgtgcggaaatcgcgcagcgtttggggttccgttcccca
aacgcggctgaagaacatctgaaggcgctggcacgcaaaggcgttattgaaattgtttcc
ggcgcatcacgcgggattcgtctgttgcaggaagaggaagaagggttgccgctggtaggt
cgtgtggctgccggtgaaccacttctggcgcaacagcatattgaaggtcattatcaggtc
gatccttccttattcaagccgaatgctgatttcctgctgcgcgtcagcgggatgtcgatg
aaagatatcggcattatggatggtgacttgctggcagtgcataaaactcaggatgtacgt
aacggtcaggtcgttgtcgcacgtattgatgacgaagttaccgttaagcgcctgaaaaaa
cagggcaataaagtcgaactgttgccagaaaatagcgagtttaaaccaattgtcgttgac
cttcgtcagcagagcttcaccattgaagggctggcggttggggttattcgcaacggcgac
tggctgtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 202 |
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| Protein Molecular Weight: | 22357 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1JHC |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >LexA repressor
MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVS
GASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSM
KDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVD
LRQQSFTIEGLAVGVIRNGDWL |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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