| Identification |
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| Name: | Putative N-acetylmannosamine-6-phosphate 2-epimerase |
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| Synonyms: | |
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| Gene Name: | nanE |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Involved in catalytic activity |
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| Specific Function: | Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (Potential) |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | - N-acetylneuraminate and N-acetylmannosamine and N-acetylglucosamine degradation PW002030
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| KEGG Pathways: | - Amino sugar and nucleotide sugar metabolism ec00520
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| KEGG Reactions: | |
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| EcoCyc Reactions: | |
1.0 | ↔ | 1.0 |
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| Complex Reactions: | |
1.0N-acyl-D-glucosamine 6-phosphate | → | 1.0N-acyl-D-mannosamine 6-phosphate |
| 1.0N-acyl-D-glucosamine 6-phosphate → 1.0N-acyl-D-mannosamine 6-phosphate ReactionCard |
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| Metabolites: | | ECMDB ID | Name | View |
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| ECMDB01062 | N-Acetyl-D-Glucosamine 6-Phosphate | MetaboCard | | ECMDB01121 | N-Acetyl-D-mannosamine 6-phosphate | MetaboCard |
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| GO Classification: | | Function |
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| catalytic activity | | isomerase activity | | N-acylglucosamine-6-phosphate 2-epimerase activity | | racemase and epimerase activity | | racemase and epimerase activity, acting on carbohydrates and derivatives | | Process |
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| alcohol metabolic process | | amino sugar metabolic process | | mannosamine metabolic process | | metabolic process | | monosaccharide metabolic process | | N-acetylmannosamine metabolic process | | small molecule metabolic process |
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| Gene Properties |
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| Blattner: | b3223 |
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| Gene Orientation | Counterclockwise |
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| Centisome Percentage: | 72.60 |
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| Left Sequence End | 3368369 |
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| Right Sequence End | 3369058 |
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| Gene Sequence: | >690 bp
ATGGCGAGACGTATTCTGGTCGTAGAAGATGAAGCTCCAATTCGCGAAATGGTCTGCTTC
GTGCTCGAACAAAATGGCTTTCAGCCGGTCGAAGCGGAAGATTATGACAGTGCTGTGAAT
CAACTGAATGAACCCTGGCCGGATTTAATTCTCCTCGACTGGATGTTACCTGGCGGCTCC
GGTATCCAGTTCATCAAACACCTCAAGCGCGAGTCGATGACCCGGGATATTCCAGTGGTG
ATGTTGACCGCCAGAGGGGAAGAAGAAGATCGCGTGCGCGGCCTTGAAACCGGCGCGGAT
GACTATATCACCAAGCCGTTTTCGCCGAAGGAGCTGGTGGCGCGAATCAAAGCGGTAATG
CGCCGTATTTCGCCAATGGCGGTGGAAGAGGTGATTGAGATGCAGGGATTAAGTCTCGAC
CCGACATCTCACCGAGTGATGGCGGGCGAAGAGCCGCTGGAGATGGGGCCGACAGAATTT
AAACTGCTGCACTTTTTTATGACGCATCCTGAGCGCGTGTACAGCCGCGAGCAGCTGTTA
AACCACGTCTGGGGAACTAACGTGTATGTGGAAGACCGCACGGTCGATGTCCACATTCGT
CGCCTGCGTAAAGCACTGGAGCCCGGCGGGCATGACCGCATGGTGCAGACCGTGCGCGGT
ACAGGATATCGTTTTTCAACCCGCTTTTAA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 229 |
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| Protein Molecular Weight: | 24073 |
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| Protein Theoretical pI: | 5 |
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| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Putative N-acetylmannosamine-6-phosphate 2-epimerase
MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQA
TRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLA
RIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSDAGCR
VIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Plumbridge, J., Vimr, E. (1999). "Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli." J Bacteriol 181:47-54. Pubmed: 9864311
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