Putative N-acetylmannosamine-6-phosphate 2-epimerase (P0A761)

Identification
Name:Putative N-acetylmannosamine-6-phosphate 2-epimerase
Synonyms:
  • ManNAc-6-P epimerase
Gene Name:nanE
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (Potential)
Cellular Location:Not Available
SMPDB Pathways:
  • N-acetylneuraminate and N-acetylmannosamine and N-acetylglucosamine degradation PW002030
KEGG Pathways:
  • Amino sugar and nucleotide sugar metabolism ec00520
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0N-Acetyl-D-mannosamine 6-phosphate ↔ 1.0N-Acetyl-D-Glucosamine 6-Phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb
1.0N-Acetyl-D-Glucosamine 6-Phosphate ↔ 1.0N-Acetyl-D-mannosamine 6-phosphate
ReactionCard
1.0N-Acyl-D-glucosamine 6-phosphate ↔ 1.0N-Acyl-D-mannosamine 6-phosphate
1.0N-Acyl-D-glucosamine 6-phosphate ↔ 1.0N-Acyl-D-mannosamine 6-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0N-Acetyl-D-mannosamine 6-phosphate ↔ 1.0N-Acetyl-D-Glucosamine 6-Phosphate
ReactionCard
Complex Reactions:
1.0N-acyl-D-glucosamine 6-phosphate → 1.0N-acyl-D-mannosamine 6-phosphate
1.0N-acyl-D-glucosamine 6-phosphate → 1.0N-acyl-D-mannosamine 6-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01062N-Acetyl-D-Glucosamine 6-PhosphateMetaboCard
ECMDB01121N-Acetyl-D-mannosamine 6-phosphateMetaboCard
GO Classification:
Function
catalytic activity
isomerase activity
N-acylglucosamine-6-phosphate 2-epimerase activity
racemase and epimerase activity
racemase and epimerase activity, acting on carbohydrates and derivatives
Process
alcohol metabolic process
amino sugar metabolic process
mannosamine metabolic process
metabolic process
monosaccharide metabolic process
N-acetylmannosamine metabolic process
small molecule metabolic process
Gene Properties
Blattner:b3223
Gene OrientationCounterclockwise
Centisome Percentage:72.60
Left Sequence End3368369
Right Sequence End3369058
Gene Sequence:
>690 bp
ATGGCGAGACGTATTCTGGTCGTAGAAGATGAAGCTCCAATTCGCGAAATGGTCTGCTTC
GTGCTCGAACAAAATGGCTTTCAGCCGGTCGAAGCGGAAGATTATGACAGTGCTGTGAAT
CAACTGAATGAACCCTGGCCGGATTTAATTCTCCTCGACTGGATGTTACCTGGCGGCTCC
GGTATCCAGTTCATCAAACACCTCAAGCGCGAGTCGATGACCCGGGATATTCCAGTGGTG
ATGTTGACCGCCAGAGGGGAAGAAGAAGATCGCGTGCGCGGCCTTGAAACCGGCGCGGAT
GACTATATCACCAAGCCGTTTTCGCCGAAGGAGCTGGTGGCGCGAATCAAAGCGGTAATG
CGCCGTATTTCGCCAATGGCGGTGGAAGAGGTGATTGAGATGCAGGGATTAAGTCTCGAC
CCGACATCTCACCGAGTGATGGCGGGCGAAGAGCCGCTGGAGATGGGGCCGACAGAATTT
AAACTGCTGCACTTTTTTATGACGCATCCTGAGCGCGTGTACAGCCGCGAGCAGCTGTTA
AACCACGTCTGGGGAACTAACGTGTATGTGGAAGACCGCACGGTCGATGTCCACATTCGT
CGCCTGCGTAAAGCACTGGAGCCCGGCGGGCATGACCGCATGGTGCAGACCGTGCGCGGT
ACAGGATATCGTTTTTCAACCCGCTTTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:229
Protein Molecular Weight:24073
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Putative N-acetylmannosamine-6-phosphate 2-epimerase
MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQA
TRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLA
RIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSDAGCR
VIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
References
External Links:
ResourceLink
Uniprot ID:P0A761
Uniprot Name:NANE_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674539
Ecogene ID:EG12816
Ecocyc:EG12816
ColiBase:b3223
Kegg Gene:b3223
EchoBASE ID:EB2667
CCDB:NANE_ECOLI
BacMap:16131113
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Plumbridge, J., Vimr, E. (1999). "Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli." J Bacteriol 181:47-54. Pubmed: 9864311