| Identification |
|---|
| Name: | ATP-dependent Clp protease proteolytic subunit |
|---|
| Synonyms: | Not Available |
|---|
| Gene Name: | clpP |
|---|
| Enzyme Class: | |
|---|
| Biological Properties |
|---|
| General Function: | response to temperature stimulus |
|---|
| Specific Function: | Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. May play the role of a master protease which is attracted to different substrates by different specificity factors such as ClpA or ClpX. Participates in the final steps of RseA-sigma-E degradation, liberating sigma-E to induce the extracytoplasmic-stress response. Degrades antitoxin MazE (PubMed:24375411). |
|---|
| Cellular Location: | Not Available |
|---|
| SMPDB Pathways: | Not Available |
|---|
| KEGG Pathways: | Not Available |
|---|
| Metabolites: | |
|---|
| GO Classification: | | Function |
|---|
| ATP-dependent peptidase activity | | cytosol | | identical protein binding | | membrane | | misfolded or incompletely synthesized protein catabolic process | | proteasomal protein catabolic process | | response to heat | | response to temperature stimulus | | serine-type endopeptidase activity | | serine-type peptidase activity |
|
|---|
| Gene Properties |
|---|
| Blattner: | Not Available |
|---|
| Gene Orientation | Not Available |
|---|
| Centisome Percentage: | Not Available |
|---|
| Left Sequence End | Not Available |
|---|
| Right Sequence End | Not Available |
|---|
| Gene Sequence: | >624
atgtcatacagcggcgaacgagataactttgcaccccatatggcgctggtgccgatggtc
attgaacagacctcacgcggtgagcgctcttttgatatctattctcgtctacttaaggaa
cgcgtcatttttctgactggccaggttgaagaccacatggctaacctgattgtggcgcag
atgctgttcctggaagcggaaaacccagaaaaagatatctatctgtacattaactcccca
ggcggggtgatcactgccgggatgtctatctatgacaccatgcagtttatcaagcctgat
gtcagcaccatctgtatgggccaggcggcctcgatgggcgctttcttgctgaccgcaggg
gcaaaaggtaaacgtttttgcctgccgaattcgcgcgtgatgattcaccaaccgttgggc
ggctaccagggccaggcgaccgatatcgaaattcatgcccgtgaaattctgaaagttaaa
gggcgcatgaatgaacttatggcgcttcatacgggtcaatcattagaacagattgaacgt
gataccgagcgcgatcgcttcctttccgcccctgaagcggtggaatacggtctggtcgat
tcgattctgacccatcgtaattga |
|---|
| Protein Properties |
|---|
| Pfam Domain Function: | Not Available |
|---|
| Protein Residues: | 207 |
|---|
| Protein Molecular Weight: | 23186 |
|---|
| Protein Theoretical pI: | Not Available |
|---|
| PDB File: | 1TYF |
| Signaling Regions: | Not Available |
|---|
| Transmembrane Regions: | Not Available |
|---|
| Protein Sequence: | >ATP-dependent Clp protease proteolytic subunit
MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQ
MLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAG
AKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIER
DTERDRFLSAPEAVEYGLVDSILTHRN |
|---|
| References |
|---|
| External Links: | |
|---|
| General Reference: | Not Available |
|---|
