| Identification |
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| Name: | Endonuclease 4 |
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| Synonyms: | Not Available |
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| Gene Name: | nfo |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | nucleic acid phosphodiester bond hydrolysis |
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| Specific Function: | Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| base-excision repair | | deoxyribonuclease IV (phage-T4-induced) activity | | DNA binding | | DNA-(apurinic or apyrimidinic site) lyase activity | | endonuclease activity | | non-recombinational repair | | nucleic acid phosphodiester bond hydrolysis | | phosphoric diester hydrolase activity | | zinc ion binding |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >858
atgaaatacattggagcgcacgttagtgctgctggcggtctggcaaatgccgcaattcgc
gccgccgaaatcgacgcaaccgcgtttgccttgttcaccaaaaaccaacgtcagtggcgt
gccgcaccgctcacgacgcaaaccatcgatgaattcaaagccgcctgtgaaaaatatcac
tacacatcggcgcaaattcttccccacgacagttatctgattaacctcggacatccggtc
actgaagctctggaaaaatcgcgcgatgcctttatagatgaaatgcagcgttgcgaacag
ctggggctttctttgctcaacttccaccctggcagccatctgatgcagatttcagaagag
gattgccttgcgcgtattgccgaatccatcaacattgcgctggataaaactcaaggtgtg
acagcggtgatagaaaacaccgccggtcagggcagtaacttagggtttaaattcgaacat
ctcgcggcgattatcgacggcgtggaagataaatcccgcgtcggcgtctgcattgatacc
tgccatgctttcgctgccgggtatgatttgcgtactccagccgaatgcgagaaaacattc
gcggattttgcccgtactgtcggctttaagtatctgcgcgggatgcaccttaacgatgcg
aaaagcacctttggcagccgcgttgaccgccatcatagcctcggtgaaggcaatatcggt
catgatgcgttccgctggatcatgcaggacgaccgtttcgacggcattccgctgatcctc
gaaaccatcaacccggatatctgggcagaagagatcgcctggctgaaagcgcaacaaact
gaaaaagcggtagcctga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 285 |
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| Protein Molecular Weight: | 31479 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1QTW |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Endonuclease 4
MKYIGAHVSAAGGLANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDEFKAACEKYH
YTSAQILPHDSYLINLGHPVTEALEKSRDAFIDEMQRCEQLGLSLLNFHPGSHLMQISEE
DCLARIAESINIALDKTQGVTAVIENTAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDT
CHAFAAGYDLRTPAECEKTFADFARTVGFKYLRGMHLNDAKSTFGSRVDRHHSLGEGNIG
HDAFRWIMQDDRFDGIPLILETINPDIWAEEIAWLKAQQTEKAVA |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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