| Identification |
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| Name: | Exodeoxyribonuclease III |
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| Synonyms: | Not Available |
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| Gene Name: | xthA |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | nucleic acid phosphodiester bond hydrolysis |
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| Specific Function: | Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| base-excision repair | | cellular response to DNA damage stimulus | | DNA binding | | DNA-(apurinic or apyrimidinic site) lyase activity | | double-stranded DNA 3'-5' exodeoxyribonuclease activity | | exodeoxyribonuclease III activity | | exonuclease activity | | intracellular | | metal ion binding | | nucleic acid phosphodiester bond hydrolysis |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >807
atgaaatttgtctcttttaatatcaacggcctgcgcgccagacctcaccagcttgaagcc
atcgtcgaaaagcaccaaccggatgtgattggcctgcaggagacaaaagttcatgacgat
atgtttccgctcgaagaggtggcgaagctcggctacaacgtgttttatcacgggcagaaa
ggccattatggcgtggcgctgctgaccaaagagacgccgattgccgtgcgtcgcggcttt
cccggtgacgacgaagaggcgcagcggcggattattatggcggaaatcccctcactgctg
ggtaatgtcaccgtgatcaacggttacttcccgcagggtgaaagccgcgaccatccgata
aaattcccggcaaaagcgcagttttatcagaatctgcaaaactacctggaaaccgaactc
aaacgtgataatccggtactgattatgggcgatatgaatatcagccctacagatctggat
atcggcattggcgaagaaaaccgtaagcgctggctgcgtaccggtaaatgctctttcctg
ccggaagagcgcgaatggatggacaggctgatgagctgggggttggtcgataccttccgc
catgcgaatccgcaaacagcagatcgtttctcatggtttgattaccgctcaaaaggtttt
gacgataaccgtggtctgcgcatcgacctgctgctcgccagccaaccgctggcagaatgt
tgcgtagaaaccggcatcgactatgaaatccgcagcatggaaaaaccgtccgatcacgcc
cccgtctgggcgaccttccgccgctaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 268 |
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| Protein Molecular Weight: | 30968 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1AKO |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Exodeoxyribonuclease III
MKFVSFNINGLRARPHQLEAIVEKHQPDVIGLQETKVHDDMFPLEEVAKLGYNVFYHGQK
GHYGVALLTKETPIAVRRGFPGDDEEAQRRIIMAEIPSLLGNVTVINGYFPQGESRDHPI
KFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPTDLDIGIGEENRKRWLRTGKCSFL
PEEREWMDRLMSWGLVDTFRHANPQTADRFSWFDYRSKGFDDNRGLRIDLLLASQPLAEC
CVETGIDYEIRSMEKPSDHAPVWATFRR |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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