DsdX permease (P08555)

Identification
Name:DsdX permease
Synonyms:Not Available
Gene Name:dsdX
Enzyme Class:Not Available
Biological Properties
General Function:Involved in gluconate transmembrane transporter activity
Specific Function:Probable permease for an unknown substrate
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:Not Available
Metabolites:
ECMDB IDNameView
ECMDB03406D-SerineMetaboCard
GO Classification:
Component
cell part
membrane
Function
carboxylic acid transmembrane transporter activity
gluconate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
organic acid transmembrane transporter activity
substrate-specific transmembrane transporter activity
transmembrane transporter activity
transporter activity
Process
carboxylic acid transport
establishment of localization
gluconate transport
monocarboxylic acid transport
organic acid transport
transport
Gene Properties
Blattner:b2365
Gene OrientationClockwise
Centisome Percentage:53.36
Left Sequence End2475869
Right Sequence End2477206
Gene Sequence:
>1338 bp
ATGCACTCTCAAATCTGGGTTGTGAGCACGCTGCTTATCAGCATCGTGTTAATTGTACTG
ACCATCGTGAAGTTCAAATTCCACCCGTTTCTGGCGCTGTTGCTGGCCAGCTTCTTCGTG
GGAACGATGATGGGCATGGGGCCACTGGATATGGTAAATGCTATTGAAAGTGGAATTGGC
GGAACGCTGGGGTTCCTCGCAGCGGTTATCGGCCTTGGCACGATACTGGGAAAAATGATG
GAAGTATCCGGGGCCGCAGAAAGAATTGGTCTGACACTTCAACGCTGCCGCTGGCTTTCA
GTTGATGTCATTATGGTGCTGGTTGGCCTGATTTGTGGCATCACGCTGTTTGTTGAAGTG
GGCGTCGTGCTATTGATTCCTCTGGCTTTTTCAATTGCCAAAAAAACCAATACCTCATTA
TTAAAGCTTGCCATTCCGCTATGTACCGCATTGATGGCAGTGCACTGCGTGGTTCCTCCA
CATCCGGCTGCTTTATATGTTGCCAATAAGCTGGGCGCAGATATCGGTTCGGTGATCGTC
TACGGTTTGCTGGTTGGGCTGATGGCATCACTGATCGGTGGCCCACTTTTCCTTAAATTT
CTGGGTCAACGACTGCCCTTTAAACCTGTACCCACAGAGTTTGCAGATCTCAAAGTTCGC
GATGAAAAAACACTACCGTCATTAGGCGCAACGTTATTCACCATACTGCTACCCATTGCG
CTGATGTTGGTTAAAACGATTGCCGAATTGAATATGGCGCGTGAGAGTGGTTTGTATATC
TTGGTTGAGTTTATTGGCAACCCTATCACTGCCATGTTTATCGCCGTGTTTGTCGCCTAT
TATGTGTTGGGTATACGCCAGCATATGAGCATGGGGACGATGCTCACACATACGGAAAAT
GGCTTCGGTTCTATTGCTAATATTTTGCTGATTATCGGGGCCGGAGGCGCATTCAACGCC
ATTTTAAAAAGCAGCAGTCTCGCTGATACGCTGGCAGTTATTCTCTCCAATATGCATATG
CACCCGATTCTTCTGGCCTGGTTAGTGGCTCTTATTCTGCATGCGGCAGTGGGCTCCGCT
ACCGTGGCAATGATGGGGGCAACGGCAATTGTTGCACCCATGCTGCCGCTGTATCCCGAC
ATCAGCCCGGAAATTATTGCGATTGCTATCGGTTCAGGTGCAATTGGCTGCACTATCGTT
ACGGACTCGCTTTTCTGGCTAGTGAAGCAATATTGCGGCGCTACGCTCAATGAAACATTT
AAATACTATACGACAGCGACATTTATCGCTTCAGTCGTCGCTCTGGCGGGCACATTCCTG
CTGTCATTTATCATCTAA
Protein Properties
Pfam Domain Function:
Protein Residues:445
Protein Molecular Weight:47163
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • 5-25
  • 29-49
  • 57-77
  • 106-126
  • 140-160
  • 178-198
  • 224-244
  • 258-278
  • 302-322
  • 343-363
  • 364-384
  • 385-405
  • 425-445
Protein Sequence:
>DsdX permease
MHSQIWVVSTLLISIVLIVLTIVKFKFHPFLALLLASFFVGTMMGMGPLDMVNAIESGIG
GTLGFLAAVIGLGTILGKMMEVSGAAERIGLTLQRCRWLSVDVIMVLVGLICGITLFVEV
GVVLLIPLAFSIAKKTNTSLLKLAIPLCTALMAVHCVVPPHPAALYVANKLGADIGSVIV
YGLLVGLMASLIGGPLFLKFLGQRLPFKPVPTEFADLKVRDEKTLPSLGATLFTILLPIA
LMLVKTIAELNMARESGLYILVEFIGNPITAMFIAVFVAYYVLGIRQHMSMGTMLTHTEN
GFGSIANILLIIGAGGAFNAILKSSSLADTLAVILSNMHMHPILLAWLVALILHAAVGSA
TVAMMGATAIVAPMLPLYPDISPEIIAIAIGSGAIGCTIVTDSLFWLVKQYCGATLNETF
KYYTTATFIASVVALAGTFLLSFII
References
External Links:
ResourceLink
Uniprot ID:P08555
Uniprot Name:DSDX_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1799764
Ecogene ID:EG10250
Ecocyc:EG10250
ColiBase:b2365
Kegg Gene:b2365
EchoBASE ID:EB0246
CCDB:DSDX_ECOLI
BacMap:16130297
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Bornstein-Forst, S. M., McFall, E., Palchaudhuri, S. (1987). "In vivo D-serine deaminase transcription start sites in wild-type Escherichia coli and in dsdA promoter mutants." J Bacteriol 169:1056-1060. Pubmed: 3029015
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Jahreis, K., Bentler, L., Bockmann, J., Hans, S., Meyer, A., Siepelmeyer, J., Lengeler, J. W. (2002). "Adaptation of sucrose metabolism in the Escherichia coli wild-type strain EC3132." J Bacteriol 184:5307-5316. Pubmed: 12218016
  • Norregaard-Madsen, M., McFall, E., Valentin-Hansen, P. (1995). "Organization and transcriptional regulation of the Escherichia coli K-12 D-serine tolerance locus." J Bacteriol 177:6456-6461. Pubmed: 7592420
  • Palchaudhuri, S., Patel, V., McFall, E. (1988). "DNA sequence of the D-serine deaminase activator gene dsdC." J Bacteriol 170:330-334. Pubmed: 3275618
  • Reizer, A., Deutscher, J., Saier, M. H. Jr, Reizer, J. (1991). "Analysis of the gluconate (gnt) operon of Bacillus subtilis." Mol Microbiol 5:1081-1089. Pubmed: 1659648
  • Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837