| Identification |
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| Name: | Transcriptional regulatory protein TyrR |
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| Synonyms: | Not Available |
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| Gene Name: | tyrR |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalanine concentrations. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| amino acid binding | | aromatic compound catabolic process | | ATP binding | | DNA binding | | intracellular | | negative regulation of transcription, DNA-templated | | phosphorelay response regulator activity | | phosphorelay signal transduction system | | protein-DNA complex | | regulation of transcription, DNA-templated | | sequence-specific DNA binding | | sequence-specific DNA binding transcription factor activity | | transcription regulatory region DNA binding | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1542
atgcgtctggaagtcttttgtgaagaccgactcggtctgacccgcgaattactcgatcta
ctcgtgctaagaggcattgatttacgcggtattgagattgatcccattgggcgaatctac
ctcaattttgctgaactggagtttgagagtttcagcagtctgatggccgaaatacgccgt
attgcgggtgttaccgatgtgcgtactgtcccgtggatgccttccgaacgtgagcatctg
gcgttgagcgcgttactggaggcgttgcctgaacctgtgctctctgtcgatatgaaaagc
aaagtggatatggcgaacccggcgagctgtcagctttttgggcaaaaattggatcgcctg
cgcaaccataccgccgcacaattgattaacggctttaattttttacgttggctggaaagc
gaaccgcaagattcgcataacgagcatgtcgttattaatgggcagaatttcctgatggag
attacgcctgtttatcttcaggatgaaaatgatcaacacgtcctgaccggtgcggtggtg
atgttgcgatcaacgattcgtatgggccgccagttgcaaaatgtcgccgcccaggacgtc
agcgccttcagtcaaattgtcgccgtcagcccgaaaatgaagcatgttgtcgaacaggcg
cagaaactggcgatgctaagcgcgccgctgctgattacgggtgacacaggtacaggtaaa
gatctctttgcctacgcctgccatcaggcaagccccagagcgggcaaaccttacctggcg
ctgaactgtgcgtctataccggaagatgcggtcgagagtgaactgtttggtcatgctccg
gaagggaagaaaggattctttgagcaggcgaacggtggttcggtgctgttggatgaaata
ggggaaatgtcaccacggatgcaggcgaaattactgcgtttccttaatgatggcactttc
cgtcgggttggcgaagaccatgaggtgcatgtcgatgtgcgggtgatttgcgctacgcag
aagaatctggtcgaactggtgcaaaaaggcatgttccgtgaagatctctattatcgtctg
aacgtgttgacgctcaatctgccgccgctacgtgactgtccgcaggacatcatgccgtta
actgagctgttcgtcgcccgctttgccgacgagcagggcgtgccgcgtccgaaactggcc
gctgacctgaatactgtacttacgcgttatgcgtggccgggaaatgtgcggcagttaaag
aacgctatctatcgcgcactgacacaactggacggttatgagctgcgtccacaggatatt
ttgttgccggattatgacgccgcaacggtagccgtgggcgaagatgcgatggaaggttcg
ctggacgaaatcaccagccgttttgaacgctcggtattaacccagctttatcgcaattat
cccagcacgcgcaaactggcaaaacgtctcggcgtttcacataccgcgattgccaataag
ttgcgggaatatggtctgagtcagaagaagaacgaagagtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 513 |
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| Protein Molecular Weight: | 57655 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2JHE |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Transcriptional regulatory protein TyrR
MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIEIDPIGRIYLNFAELEFESFSSLMAEIRR
IAGVTDVRTVPWMPSEREHLALSALLEALPEPVLSVDMKSKVDMANPASCQLFGQKLDRL
RNHTAAQLINGFNFLRWLESEPQDSHNEHVVINGQNFLMEITPVYLQDENDQHVLTGAVV
MLRSTIRMGRQLQNVAAQDVSAFSQIVAVSPKMKHVVEQAQKLAMLSAPLLITGDTGTGK
DLFAYACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
GEMSPRMQAKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLVELVQKGMFREDLYYRL
NVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLAADLNTVLTRYAWPGNVRQLK
NAIYRALTQLDGYELRPQDILLPDYDAATVAVGEDAMEGSLDEITSRFERSVLTQLYRNY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKNEE |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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