L(+)-tartrate dehydratase subunit alpha (P05847)

Identification
Name:L(+)-tartrate dehydratase subunit alpha
Synonyms:
  • L-TTD alpha
Gene Name:ttdA
Enzyme Class:
Biological Properties
General Function:Involved in lyase activity
Specific Function:(R,R)-tartrate = oxaloacetate + H(2)O
Cellular Location:Not Available
SMPDB Pathways:
  • glycolate and glyoxylate degradation II PW002021
KEGG Pathways:
  • Glyoxylate and dicarboxylate metabolism ec00630
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Tartaric acid ↔ 1.0Water + 1.0Oxalacetic acid
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Tartaric acid ↔ 1.0Water + 1.0Oxalacetic acid
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb+1.0Thumb
1.0Tartaric acid → 1.0Oxalacetic acid + 1.0Water
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00223Oxalacetic acidMetaboCard
ECMDB00956Tartaric acidMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
lyase activity
Gene Properties
Blattner:b3061
Gene OrientationClockwise
Centisome Percentage:69.07
Left Sequence End3204485
Right Sequence End3205396
Gene Sequence:
>912 bp
ATGCGACTATTTAACTGGCGACGTCAGGCGGTGTTAAACGCCATGCCACTGGTCAAACCT
GACCAGGTACGTACACCGTGGCATGAATTCTGGCGACGATTTCGCCGTCAGCATATGGCG
ATGACCGCCGCATTATTCGTTATTTTATTGATTGTGGTGGCCATTTTTGCACGCTGGATC
GCTCCCTATGACGCCGAAAATTATTTTGATTATGACAATCTGAATAACGGACCTTCTTTG
CAGCACTGGTTTGGCGTCGATTCACTGGGGCGTGACATTTTCAGCCGTGTCCTGGTTGGT
GCGCAAATCTCGCTGGCGGCGGGCGTGTTTGCCGTGTTTATCGGTGCGGCGATCGGGACG
TTGCTGGGCTTGCTCGCTGGATATTATGAAGGCTGGTGGGATCGGCTGATCATGCGCATT
TGCGATGTGCTGTTTGCCTTCCCGGGTATTTTACTGGCGATCGCTGTTGTTGCGGTGTTG
GGAAGCGGCATTGCTAACGTGATTATTGCAGTCGCCATTTTTTCCATCCCCGCGTTTGCC
CGCCTGGTGCGCGGCAACACGCTGGTGTTGAAACAGCAAACCTTTATTGAGTCAGCACGC
AGTATTGGTGCCAGCGATATGACCGTTTTGTTGCGTCATATCCTGCCTGGGACCGTCTCT
TCTATCGTGGTGTTTTTCACCATGCGCATTGGTACCTCGATTATCTCTGCCGCCAGCCTC
TCATTTCTCGGCCTCGGTGCGCAGCCGCCGACACCAGAGTGGGGAGCAATGCTCAATGAG
GCTCGAGCGGATATGGTTATCGCGCCGCATGTCGCTGTTTTTCCGGCCCTGGCTATTTTT
CTGACCGTACTGGCGTTCAATTTGTTGGGCGATGGTTTACGCGATGCGCTGGATCCGAAA
ATTAAAGGATAG
Protein Properties
Pfam Domain Function:
Protein Residues:303
Protein Molecular Weight:32733
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>L(+)-tartrate dehydratase subunit alpha
MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNM
QKAIDLNRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDE
VNTGKNTGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEGVVKFVFE
NISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNR
LGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTR
SAL
References
External Links:
ResourceLink
Uniprot ID:P05847
Uniprot Name:TTDA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062409
Ecogene ID:EG11168
Ecocyc:EG11168
ColiBase:b3061
Kegg Gene:b3061
EchoBASE ID:EB1156
CCDB:TTDA_ECOLI
BacMap:16130957
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Nesin, M., Lupski, J. R., Svec, P., Godson, G. N. (1987). "Possible new genes as revealed by molecular analysis of a 5-kb Escherichia coli chromosomal region 5' to the rpsU-dnaG-rpoD macromolecular-synthesis operon." Gene 51:149-161. Pubmed: 3297921
  • Oshima, T., Biville, F. (2006). "Functional identification of ygiP as a positive regulator of the ttdA-ttdB-ygjE operon." Microbiology 152:2129-2135. Pubmed: 16804186
  • Reaney, S. K., Begg, C., Bungard, S. J., Guest, J. R. (1993). "Identification of the L-tartrate dehydratase genes (ttdA and ttdB) of Escherichia coli and evolutionary relationship with the class I fumarase genes." J Gen Microbiol 139:1523-1530. Pubmed: 8371115