3-dehydroquinate dehydratase (P05194)

Identification
Name:3-dehydroquinate dehydratase
Synonyms:
  • 3-dehydroquinase
  • Type I DHQase
Gene Name:aroD
Enzyme Class:
Biological Properties
General Function:Involved in 3-dehydroquinate dehydratase activity
Specific Function:3-dehydroquinate = 3-dehydroshikimate + H(2)O
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Metabolic pathways eco01100
  • Phenylalanine, tyrosine and tryptophan biosynthesis ec00400
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.03-Dehydroquinate ↔ 1.03-Dehydro-shikimate + 1.0Water
ReactionCard
SMPDB Reactions:
1.0Thumb → 1.0Thumb+1.03-dehydroshikimate+1.0Thumb
1.03-Dehydroquinate → 1.0Water + 1.03-dehydroshikimate + 1.03-Dehydro-shikimate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.03-Dehydroquinate ↔ 1.03-Dehydro-shikimate + 1.0Water
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB040483-Dehydro-shikimateMetaboCard
ECMDB040493-DehydroquinateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
3-dehydroquinate dehydratase activity
carbon-oxygen lyase activity
catalytic activity
hydro-lyase activity
lyase activity
Process
metabolic process
Gene Properties
Blattner:b1693
Gene OrientationClockwise
Centisome Percentage:38.21
Left Sequence End1772710
Right Sequence End1773468
Gene Sequence:
>759 bp
ATGTCTGACTGGAACCCCTCTTTATATCTACACTTTTCCGCTGAACGATCGCGTCCGGCG
GTGGAGCTGCTTGCCAGAGTGCCGCTGGAAAATGTCGAATATGTTGCCGATCTTGGCTGT
GGCCCAGGTAACAGCACCGCCCTTCTACAACAACGTTGGCCTGCGGCCAGGATAACAGGC
ATCGACTCGTCTCCGGCGATGATTGCTGAAGCGCGCAGTGCTTTGCCAGACTGCCAGTTC
GTGGAAGCAGACATCCGCAACTGGCAACCGGTACAGGCACTCGATCTGATTTTTGCTAAT
GCCTCACTGCAATGGCTGCCCGACCACTACGAATTGTTTCCTCATCTGGTTTCTTTACTT
AATCCGCAGGGCGTGCTGGCAGTACAGATGCCAGATAACTGGCTGGAGCCGACCCATGTG
CTCATGCGCGAAGTTGCCTGGGAACAAAACTACCCGGATCGCGGGCGTGAGCCGTTGGCT
GGCGTTCATGCTTACTACGATATTTTGAGCGAAGCCGGATGTGAGGTCGATATCTGGCGA
ACCACCTACTATCACCAGATGCCGTCACACCAGGCGATTATCGATTGGGTGACTGCCACT
GGATTACGTCCGTGGTTACAGGATCTGACCGAGAGCGAACAGCAGCTTTTTCTTAAGCGC
TACCATCAGATGCTGGAAGAGCAGTATCCACTGCAAGAGAACGGACAGATACTGCTGGCA
TTTCCGCGTCTGTTTATTGTTGCCCGGCGTATGGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:252
Protein Molecular Weight:27466
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>3-dehydroquinate dehydratase
MKTVTVKDLVIGTGAPKIIVSLMAKDIASVKSEALAYREADFDILEWRVDHYADLSNVES
VMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTG
DDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSD
VLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVN
DLRTVLTILHQA
References
External Links:
ResourceLink
Uniprot ID:P05194
Uniprot Name:AROD_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675003
Ecogene ID:EG10076
Ecocyc:EG10076
ColiBase:b1693
Kegg Gene:b1693
EchoBASE ID:EB0074
CCDB:AROD_ECOLI
BacMap:16129649
General Reference:
  • Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Chaudhuri, S., Duncan, K., Graham, L. D., Coggins, J. R. (1991). "Identification of the active-site lysine residues of two biosynthetic 3-dehydroquinases." Biochem J 275 ( Pt 1):1-6. Pubmed: 1826831
  • Deka, R. K., Kleanthous, C., Coggins, J. R. (1992). "Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase." J Biol Chem 267:22237-22242. Pubmed: 1429576
  • Duncan, K., Chaudhuri, S., Campbell, M. S., Coggins, J. R. (1986). "The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase." Biochem J 238:475-483. Pubmed: 3541912
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553