| Identification |
|---|
| Name: | Exodeoxyribonuclease I |
|---|
| Synonyms: | Not Available |
|---|
| Gene Name: | sbcB |
|---|
| Enzyme Class: | |
|---|
| Biological Properties |
|---|
| General Function: | RNA phosphodiester bond hydrolysis, exonucleolytic |
|---|
| Specific Function: | Degrades single-stranded DNA (ssDNA) in a highly processive manner (PubMed:23609540). Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase (PubMed:1329027). |
|---|
| Cellular Location: | Not Available |
|---|
| SMPDB Pathways: | Not Available |
|---|
| KEGG Pathways: | |
|---|
| Metabolites: | |
|---|
| GO Classification: | | Function |
|---|
| 3'-5'-exoribonuclease activity | | DNA catabolic process | | DNA repair | | exodeoxyribonuclease I activity | | magnesium ion binding | | nucleic acid phosphodiester bond hydrolysis | | RNA phosphodiester bond hydrolysis, exonucleolytic | | single-stranded DNA binding |
|
|---|
| Gene Properties |
|---|
| Blattner: | Not Available |
|---|
| Gene Orientation | Not Available |
|---|
| Centisome Percentage: | Not Available |
|---|
| Left Sequence End | Not Available |
|---|
| Right Sequence End | Not Available |
|---|
| Gene Sequence: | >1428
atgatgaatgacggtaagcaacaatctacctttttgtttcacgattacgaaacctttggc
acgcaccccgcgttagatcgccctgcacagttcgcagccattcgcaccgatagcgaattc
aatgtcatcggcgaacccgaagtcttttactgcaagcccgctgatgactatttaccccag
ccaggagccgtattaattaccggtattaccccgcaggaagcacgggcgaaaggagaaaac
gaagccgcgtttgccgcccgtattcactcgctttttaccgtaccgaagacctgtattctg
ggctacaacaatgtgcgtttcgacgacgaagtcacacgcaacattttttatcgtaatttc
tacgatccttacgcctggagctggcagcatgataactcgcgctgggatttactggatgtt
atgcgtgcctgttatgccctgcgcccggaaggaataaactggcctgaaaatgatgacggt
ctaccgagctttcgccttgagcatttaaccaaagcgaatggtattgaacatagcaacgcc
cacgatgcgatggctgatgtgtacgccactattgcgatggcaaagctggtaaaaacgcgt
cagccacgcctgtttgattatctctttacccatcgtaataaacacaaactgatggcgttg
attgatgttccgcagatgaaacccctggtgcacgtttccggaatgtttggagcatggcgc
ggcaataccagctgggtggcaccgctggcgtggcatcctgaaaatcgcaatgccgtaatt
atggtggatttggcaggagacatttcgccattactggaactggatagcgacacattgcgc
gagcgtttatataccgcaaaaaccgatcttggcgataacgccgccgttccggttaagctg
gtgcatatcaataaatgtccggtgctggcccaggcgaatacgctacgcccggaagatgcc
gaccgactgggaattaatcgtcagcattgcctcgataacctgaaaattctgcgtgaaaat
ccgcaagtgcgcgaaaaagtggtggcgatattcgcggaagccgaaccgtttacgccttca
gataacgtggatgcacagctttataacggctttttcagtgacgcagatcgtgcagcaatg
aaaattgtgctggaaaccgagccgcgtaatttaccggcactggatatcacttttgttgat
aaacggattgaaaagctgttgttcaattatcgggcacgcaacttcccggggacgctggat
tatgccgagcagcaacgctggctggagcaccgtcgccaggtcttcacgccagagtttttg
cagggttatgctgatgaattgcagatgctggtacaacaatatgccgatgacaaagagaaa
gtggcgctgttaaaagcactttggcagtacgcggaagagattgtctaa |
|---|
| Protein Properties |
|---|
| Pfam Domain Function: | Not Available |
|---|
| Protein Residues: | 475 |
|---|
| Protein Molecular Weight: | 54500 |
|---|
| Protein Theoretical pI: | Not Available |
|---|
| PDB File: | 1FXX |
| Signaling Regions: | Not Available |
|---|
| Transmembrane Regions: | Not Available |
|---|
| Protein Sequence: | >Exodeoxyribonuclease I
MMNDGKQQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDYLPQ
PGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNF
YDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPENDDGLPSFRLEHLTKANGIEHSNA
HDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKHKLMALIDVPQMKPLVHVSGMFGAWR
GNTSWVAPLAWHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKL
VHINKCPVLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPS
DNVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNFPGTLD
YAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALLKALWQYAEEIV |
|---|
| References |
|---|
| External Links: | |
|---|
| General Reference: | Not Available |
|---|
