| Record Information |
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| Version | 2.0 |
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| Creation Date | 2012-05-31 14:19:45 -0600 |
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| Update Date | 2015-07-07 11:48:35 -0600 |
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| Secondary Accession Numbers | |
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| Identification |
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| Name: | Hydrogen selenide |
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| Description | Hydrogen selenide is a metabolite of selenium which could have potential antiangiogenic effect in the chemoprevention of cancer. The hydrogen selenide is a key intermediate in the selenium methylation metabolism of inorganic and organic selenium compounds. Accumulation of the hydrogen selenide resulting from inhibition of the selenium methylation metabolism, detoxification metabolic pathway of selenium, is found in animals following repeated administration of a toxic dose of selenocystine. The excess of the hydrogen selenide produced by inhibition of the selenium methylation metabolism contributes to the hepatotoxicity caused by selenocystine. (PMID: 9414580, 11799926) |
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| Structure | |
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| Synonyms: | - Dihydridoselenium
- Dihydrogen monoselenide
- Dihydrogen selenide
- H2Se
- H2Se
- Hydrogen selenide
- Selane
- Selenium dihydride
- Selenium hydride
- Selenium hydride (SeH2)
- [SeH2]
- [SeH2]
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| Chemical Formula: | H2Se |
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| Weight: | Average: 80.98
Monoisotopic: 81.932171892 |
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| InChI Key: | SPVXKVOXSXTJOY-UHFFFAOYSA-N |
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| InChI: | InChI=1S/H2Se/h1H2 |
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| CAS number: | Not Available |
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| IUPAC Name: | hydrogen selenide |
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| Traditional IUPAC Name: | hydrogen selenide |
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| SMILES: | [SeH2] |
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| Chemical Taxonomy |
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| Description | belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. |
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| Kingdom | Inorganic compounds |
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| Super Class | Homogeneous non-metal compounds |
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| Class | Homogeneous other non-metal compounds |
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| Sub Class | Not Available |
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| Direct Parent | Homogeneous other non-metal compounds |
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| Alternative Parents | |
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| Substituents | - Homogeneous other non metal
- Inorganic selenide
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| Molecular Framework | Not Available |
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| External Descriptors | |
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| Physical Properties |
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| State: | Solid |
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| Charge: | -1 |
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| Melting point: | Not Available |
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| Experimental Properties: | |
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| Predicted Properties | |
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| Biological Properties |
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| Cellular Locations: | Cytoplasm |
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| Reactions: | |
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| SMPDB Pathways: | |
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| KEGG Pathways: | |
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| EcoCyc Pathways: | Not Available |
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| Concentrations |
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| Not Available |
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| Spectra |
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| Spectra: | |
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| References |
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| References: | - Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
- Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
- Lu J, Jiang C: Antiangiogenic activity of selenium in cancer chemoprevention: metabolite-specific effects. Nutr Cancer. 2001;40(1):64-73. Pubmed: 11799926
- Sayato Y, Nakamuro K, Hasegawa T: [Selenium methylation and toxicity mechanism of selenocystine]. Yakugaku Zasshi. 1997 Nov;117(10-11):665-72. Pubmed: 9414580
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| Synthesis Reference: | Not Available |
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| Material Safety Data Sheet (MSDS) | Not Available |
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| Links |
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| External Links: | |
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