2.0 2012-05-31 14:19:45 -0600 2015-07-07 11:48:35 -0600 ECMDB11110 M2MDB000804 Hydrogen selenide Hydrogen selenide is a metabolite of selenium which could have potential antiangiogenic effect in the chemoprevention of cancer. The hydrogen selenide is a key intermediate in the selenium methylation metabolism of inorganic and organic selenium compounds. Accumulation of the hydrogen selenide resulting from inhibition of the selenium methylation metabolism, detoxification metabolic pathway of selenium, is found in animals following repeated administration of a toxic dose of selenocystine. The excess of the hydrogen selenide produced by inhibition of the selenium methylation metabolism contributes to the hepatotoxicity caused by selenocystine. (PMID: 9414580, 11799926) Dihydridoselenium Dihydrogen monoselenide Dihydrogen selenide H2Se H₂Se Hydrogen selenide Selane Selenium dihydride Selenium hydride Selenium hydride (SeH2) [SeH2] [SeH₂] H2Se 80.98 81.932171892 hydrogen selenide hydrogen selenide [SeH2] InChI=1S/H2Se/h1H2 SPVXKVOXSXTJOY-UHFFFAOYSA-N Solid Cytoplasm Periplasm logp -0.5 ChemAxon iupac hydrogen selenide ChemAxon average_mass 80.98 ChemAxon mono_mass 81.932171892 ChemAxon smiles [SeH2] ChemAxon formula H2Se ChemAxon inchi InChI=1S/H2Se/h1H2 ChemAxon inchikey SPVXKVOXSXTJOY-UHFFFAOYSA-N ChemAxon polar_surface_area 0 ChemAxon refractivity 14.71 ChemAxon polarizability 2.81 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 1 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Selenoamino acid metabolism ec00450 Metabolic pathways eco01100 Selenium metabolism The selenium metabolism begins with the introduction of selenate and selenite to the cytosol through a sulphate permease system. Once in the cell, selenate can be reduced to selenite through nitrate reductases A and Z. Selenite then interacts with glutathione and 2 hydrogen ions resulting in the release of 2 water molecules, a hydroxide molecule, a glutathione disulfide and a selenodiglutathione. The latter compound then reacts with NADPH+H resulting in the release of a NADP, a glutathione and a glutathioselenol. Glutathiolselenol can then be oxidize resulting in a a glutathiolselenol ion which can then interact with a water molecule resulting in a release of glutathion and selenium Glutathiolselenol can also react with NADPH and hydrogen ion resulting in a release of glutathione, NADP, a hydroxide molecule and a hydrogen selenide. This compound can react in a reversible reaction by being oxidized resulting in a hydrogen selenide ion . This compound can then be phosphorylated by interacting with an ATP and releasing a AMP, a phosphate and a selenophosphate. PW001894 Metabolic Specdb::NmrOneD 150780 Specdb::NmrOneD 150781 Specdb::NmrOneD 150782 Specdb::NmrOneD 150783 Specdb::NmrOneD 150784 Specdb::NmrOneD 150785 Specdb::NmrOneD 150786 Specdb::NmrOneD 150787 Specdb::NmrOneD 150788 Specdb::NmrOneD 150789 Specdb::MsMs 25841 Specdb::MsMs 25842 Specdb::MsMs 25843 Specdb::MsMs 32399 Specdb::MsMs 32400 Specdb::MsMs 32401 HMDB11110 533 C01528 CPD-678 SE Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. 22080510 Sayato Y, Nakamuro K, Hasegawa T: [Selenium methylation and toxicity mechanism of selenocystine]. Yakugaku Zasshi. 1997 Nov;117(10-11):665-72. 9414580 Lu J, Jiang C: Antiangiogenic activity of selenium in cancer chemoprevention: metabolite-specific effects. Nutr Cancer. 2001;40(1):64-73. 11799926 Thioredoxin reductase P0A9P4 TRXB_ECOLI trxB http://ecmdb.ca/proteins/P0A9P4.xml Cysteine synthase A P0ABK5 CYSK_ECOLI cysK http://ecmdb.ca/proteins/P0ABK5.xml Selenide, water dikinase P16456 SELD_ECOLI selD http://ecmdb.ca/proteins/P16456.xml Cysteine synthase B P16703 CYSM_ECOLI cysM http://ecmdb.ca/proteins/P16703.xml Cysteine desulfurase_ P77444 SUFS_ECOLI sufS http://ecmdb.ca/proteins/P77444.xml Adenosine triphosphate + Hydrogen selenide + Water <> Adenosine monophosphate + Phosphoroselenoic acid + Phosphate R03595 Hydrogen selenide + 3 NADP + 3 Water <> Selenite +3 NADPH +5 Hydrogen ion R03596 Selenocysteine + Reduced acceptor <> Hydrogen selenide + L-Alanine + Acceptor R03599 O-Acetylserine + Hydrogen selenide <> Selenocysteine + Acetic acid R03601 Adenosine triphosphate + Hydrogen selenide + Water > Adenosine monophosphate + Phosphoroselenoic acid + Inorganic phosphate Selenocysteine + reduced acceptor > Hydrogen selenide + L-Alanine + acceptor Adenosine triphosphate + Hydrogen selenide + Water <> Adenosine monophosphate + Phosphoroselenoic acid + Phosphate Hydrogen selenide + 3 NADP + 3 Water <> Selenite +3 NADPH