alpha-Ketoglutarate (ECMDB02812) (M2MDB000466)

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

gdhA

Uniprot ID:

P00370

Molecular weight:

48581

Reactions

General function:

Involved in transferase activity

Specific function:

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Gene Name:

aspC

Uniprot ID:

P00509

Molecular weight:

43573

Reactions

General function:

Involved in transferase activity

Specific function:

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate

Gene Name:

tyrB

Uniprot ID:

P04693

Molecular weight:

43537

Reactions

General function:

Involved in transferase activity

Specific function:

L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

Gene Name:

hisC

Uniprot ID:

P06986

Molecular weight:

39360

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Gene Name:

icd

Uniprot ID:

P08200

Molecular weight:

45756

Reactions

General function:

Involved in catalytic activity

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltB

Uniprot ID:

P09831

Molecular weight:

166708

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltD

Uniprot ID:

P09832

Molecular weight:

52015

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Gene Name:

lpdA

Uniprot ID:

P0A9P0

Molecular weight:

50688

Reactions

General function:

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucA

Uniprot ID:

P0AFG3

Molecular weight:

105061

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucB

Uniprot ID:

P0AFG6

Molecular weight:

44011

Reactions

General function:

Involved in thiamine pyrophosphate binding

Specific function:

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)

Gene Name:

menD

Uniprot ID:

P17109

Molecular weight:

61367

Reactions

General function:

Involved in transaminase activity

Specific function:

Involved in both the arginine and lysine biosynthetic pathways

Gene Name:

argD

Uniprot ID:

P18335

Molecular weight:

43767

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

Gene Name:

gabT

Uniprot ID:

P22256

Molecular weight:

45774

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis

Gene Name:

serC

Uniprot ID:

P23721

Molecular weight:

39783

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Uniprot ID:

P37610

Molecular weight:

32409

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine. Alpha-ketobutyrate and pyruvate can also act as amino acceptors, although much less efficiently

Gene Name:

patA

Uniprot ID:

P42588

Molecular weight:

49661

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate

Gene Name:

puuE

Uniprot ID:

P50457

Molecular weight:

44729

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase

Gene Name:

astC

Uniprot ID:

P77581

Molecular weight:

43665

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnB

Uniprot ID:

P77690

Molecular weight:

41649

Reactions

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Specific function unknown

Gene Name:

yfbQ

Uniprot ID:

P0A959

Molecular weight:

45517

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts on leucine, isoleucine and valine

Gene Name:

ilvE

Uniprot ID:

P0AB80

Molecular weight:

34093

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in ECA elongation

Gene Name:

rffA

Uniprot ID:

P27833

Molecular weight:

41901

General function:

Amino acid transport and metabolism

Specific function:

Specific function unknown

Gene Name:

yfdZ

Uniprot ID:

P77434

Molecular weight:

46216

Reactions