Ferric enterobactin transport ATP-binding protein fepC (P23878)

Identification
Name:Ferric enterobactin transport ATP-binding protein fepC
Synonyms:Not Available
Gene Name:fepC
Enzyme Class:
Biological Properties
General Function:Involved in nucleotide binding
Specific Function:Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system
Cellular Location:Cell inner membrane; Peripheral membrane protein (Potential)
SMPDB Pathways:
  • Biosynthesis of siderophore group nonribosomal peptides PW000760
  • inner membrane transport PW000786
KEGG Pathways:
  • ABC transporters ec02010
  • Biosynthesis of siderophore group nonribosomal peptides ec01053
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0Thumb ? 1.0Thumb+1.0Adenosine diphosphate+1.0Thumb+1.0Thumb
1.0Ferric enterobactin + 1.0Adenosine triphosphate + 1.0Water ? 1.0Ferric enterobactin + 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Ferric enterobactin → 1.0ADP + 1.0Ferric enterobactin + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0ferric 2,3-dihydroxybenzoylserine → 1.0ADP + 1.0ferric 2,3-dihydroxybenzoylserine + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21331ferric 2,3-dihydroxybenzoylserineMetaboCard
ECMDB21372Ferric enterobactinMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
purine nucleoside binding
pyrophosphatase activity
Gene Properties
Blattner:b0588
Gene OrientationCounterclockwise
Centisome Percentage:13.33
Left Sequence End618607
Right Sequence End619422
Gene Sequence:
>816 bp
ATGCAGTATTGGGGAAAAATCATTGGCGTGGCCGTGGCCTTACTGATGGGCGGCGGCTTT
TGGGGCGTAGTGTTAGGCCTGTTAATTGGCCATATGTTTGATAAAGCCCGTAGCCGTAAA
ATGGCGTGGTTCGCCAACCAGCGTGAGCGTCAGGCGCTGTTTTTTGCCACCACTTTTGAA
GTGATGGGGCATTTAACCAAATCCAAAGGTCGCGTCACGGAGGCTGATATTCATATCGCC
AGCCAGTTGATGGACCGAATGAATCTTCATGGCGCTTCCCGTACTGCGGCGCAAAATGCG
TTCCGGGTGGGAAAATCAGACAATTACCCGCTGCGCGAAAAGATGCGCCAGTTTCGCAGT
GTCTGCTTTGGTCGTTTTGACTTAATTCGTATGTTTCTGGAGATCCAGATTCAGGCGGCG
TTTGCTGATGGTTCACTGCACCCGAATGAACGGGCGGTGCTGTATGTCATTGCAGAAGAA
TTAGGGATCTCCCGCGCTCAGTTTGACCAGTTTTTGCGCATGATGCAGGGCGGTGCACAG
TTTGGCGGCGGTTATCAGCAGCAAACTGGCGGTGGTAACTGGCAGCAAGCGCAGCGTGGC
CCAACGCTGGAAGATGCCTGTAATGTGCTGGGCGTGAAGCCGACGGATGATGCGACCACC
ATCAAACGTGCCTACCGTAAGCTGATGAGTGAACACCATCCCGATAAGCTGGTGGCGAAA
GGTTTGCCGCCTGAGATGATGGAGATGGCGAAGCAGAAAGCGCAGGAAATTCAGCAGGCA
TATGAGCTGATAAAGCAGCAGAAAGGGTTTAAATGA
Protein Properties
Pfam Domain Function:
Protein Residues:271
Protein Molecular Weight:29784
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Ferric enterobactin transport ATP-binding protein fepC
MTESVARLRGEQLTLGYGKYTVAENLTVEIPDGHFTAIIGPNGCGKSTLLRTLSRLMTPA
HGHVWLDGEHIQHYASKEVARRIGLLAQNATTPGDITVQELVARGRYPHQPLFTRWRKED
EEAVTKAMQATGITHLADQSVDTLSGGQRQRAWIAMVLAQETAIMLLDEPTTWLDISHQI
DLLELLSELNREKGYTLAAVLHDLNQACRYASHLIALREGKIVAQGAPKEIVTAELIERI
YGLRCMIIDDPVAGTPLVVPLGRTAPSTANS
References
External Links:
ResourceLink
Uniprot ID:P23878
Uniprot Name:FEPC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21321936
Ecogene ID:EG10295
Ecocyc:EG10295
ColiBase:b0588
Kegg Gene:b0588
EchoBASE ID:EB0291
CCDB:FEPC_ECOLI
BacMap:16128571
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Shea, C. M., McIntosh, M. A. (1991). "Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli." Mol Microbiol 5:1415-1428. Pubmed: 1838574