D-tagatose-1,6-bisphosphate aldolase subunit gatY (P0C8J6)

Identification
Name:D-tagatose-1,6-bisphosphate aldolase subunit gatY
Synonyms:
  • TBPA
  • TagBP aldolase
  • D-tagatose-bisphosphate aldolase class II
  • Tagatose-bisphosphate aldolase
Gene Name:gatY
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:Catalytic subunit of the tagatose-1,6-bisphosphate aldolase gatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires gatZ subunit for full activity and stability. Is involved in the catabolism of galactitol
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
SMPDB Reactions:
1.0D-tagatofuranose 1,6-bisphosphate → 1.0Thumb+1.0D-Glyceraldehyde 3-phosphate+1.0Thumb
1.0D-tagatofuranose 1,6-bisphosphate → 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb+1.0Thumb
1.0D-Tagatose 1,6-bisphosphate → 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01112D-Glyceraldehyde 3-phosphateMetaboCard
ECMDB06872D-Tagatose 1,6-bisphosphateMetaboCard
ECMDB01473Dihydroxyacetone phosphateMetaboCard
GO Classification:
Function
aldehyde-lyase activity
binding
carbon-carbon lyase activity
catalytic activity
cation binding
fructose-bisphosphate aldolase activity
ion binding
lyase activity
metal ion binding
transition metal ion binding
zinc ion binding
Process
alcohol metabolic process
carbohydrate metabolic process
disaccharide metabolic process
glucose catabolic process
glucose metabolic process
glycolysis
hexose metabolic process
lactose catabolic process
lactose catabolic process via tagatose-6-phosphate
lactose metabolic process
metabolic process
monosaccharide metabolic process
oligosaccharide metabolic process
primary metabolic process
small molecule metabolic process
Gene Properties
Blattner:b2096
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>855 bp
ATGACGCTATTTACAACCTTACTGGTGTTAATTTTCGAGCGCCTGTTTAAGTTGGGCGAG
CACTGGCAGCTTGATCATCGTCTTGAAGCGTTCTTTCGGCGGGTGAAACATTTTTCTCTC
GGGCGCACGTTAGGCATGACCATTATTGCGATGGGCGTGACTTTTTTACTGTTACGCGCA
TTGCAGGGAGTATTGTTCAACGTTCCCACGCTACTGGTGTGGCTGCTGATTGGTTTGCTG
TGTATTGGCGCAGGTAAAGTTCGTCTTCATTATCATGCTTATCTGACAGCTGCTTCACGT
AATGATAGCCATGCCCGTGCCACGATGGCTGGCGAACTCACCATGATTCACGGCGTCCCG
GCAGGCTGCGACGAACGTGAGTATTTGCGTGAGCTGCAAAATGCATTGCTGTGGATTAAC
TTTCGTTTTTATCTTGCACCGCTGTTCTGGCTGATTGTGGGGGGAACCTGGGGACCCGTT
ACGCTGATGGGGTATGCGTTTTTGCGTGCATGGCAATACTGGCTGGCGCGATATCAGACG
CCGCATCATCGTTTACAGTCCGGCATTGATGCCGTGCTTCATGTACTGGATTGGGTGCCG
GTTCGTCTTGCGGGTGTGGTATATGCCTTGATCGGTCATGGTGAGAAAGCGTTACCGGCC
TGGTTTGCTTCGCTGGGTGATTTCCATACTTCGCAGTATCAGGTGTTAACGCGTCTGGCG
CAGTTCTCTCTGGCGCGTGAACCGCATGTCGATAAGGTGGAGACGCCGAAGGCAGCGGTT
TCAATGGCGAAGAAAACCTCGTTCGTGGTCGTGGTGGTGATTGCACTACTGACGATTTAC
GGGGCGTTGGTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:284
Protein Molecular Weight:30812
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>D-tagatose-1,6-bisphosphate aldolase subunit gatY
MYVVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAANLHAPVIIAGTPGTFTHAGTE
NLLALVSAMAKQYHHPLAIHLDHHTKFDDIAQKVRSGVRSVMIDASHLPFAQNISRVKEV
VDFCHRFDVSVEAELGQLGGQEDDVQVNEADALYTNPAQAREFAEATGIDSLAVAIGTAH
GMYASAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNAFS
QALKNYLTEHPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA
References
External Links:
ResourceLink
Uniprot ID:P0C8J6
Uniprot Name:GATY_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21238959
ColiBase:b2096
Kegg Gene:b2096
EchoBASE ID:EB2318
CCDB:GATY_ECOLI
BacMap:90111384
General Reference:
  • Blankenhorn, D., Phillips, J., Slonczewski, J. L. (1999). "Acid- and base-induced proteins during aerobic and anaerobic growth of Escherichia coli revealed by two-dimensional gel electrophoresis." J Bacteriol 181:2209-2216. Pubmed: 10094700
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Brinkkotter, A., Shakeri-Garakani, A., Lengeler, J. W. (2002). "Two class II D-tagatose-bisphosphate aldolases from enteric bacteria." Arch Microbiol 177:410-419. Pubmed: 11976750
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Nobelmann, B., Lengeler, J. W. (1996). "Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism." J Bacteriol 178:6790-6795. Pubmed: 8955298