2.0 2015-09-08 20:08:21 -0600 2015-09-14 11:20:14 -0600 ECMDB24766 M2MDB006883 DG(12:0/19:iso/0:0) DG(12:0/19:iso/0:0) belongs to the family of Diacylglycerols. These are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. DG(12:0/19:iso/0:0) is also a substrate of diacylglycerol kinase. It is involved in the phospholipid metabolic pathway. C34H66O5 554.897 554.491025225 1-(dodecanoyloxy)-3-hydroxypropan-2-yl 17-methyloctadecanoate 1-(dodecanoyloxy)-3-hydroxypropan-2-yl 17-methyloctadecanoate CCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCC(C)C InChI=1S/C34H66O5/c1-4-5-6-7-8-14-18-21-24-27-33(36)38-30-32(29-35)39-34(37)28-25-22-19-16-13-11-9-10-12-15-17-20-23-26-31(2)3/h31-32,35H,4-30H2,1-3H3 QJPLJPKQDLVDLD-UHFFFAOYSA-N logp 9.61 ALOGPS logs -7.39 ALOGPS solubility 2.27e-05 g/l ALOGPS logp 11.4 ChemAxon pka_strongest_acidic 14.58 ChemAxon pka_strongest_basic -3 ChemAxon iupac 1-(dodecanoyloxy)-3-hydroxypropan-2-yl 17-methyloctadecanoate ChemAxon average_mass 554.897 ChemAxon mono_mass 554.491025225 ChemAxon smiles CCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCC(C)C ChemAxon formula C34H66O5 ChemAxon inchi InChI=1S/C34H66O5/c1-4-5-6-7-8-14-18-21-24-27-33(36)38-30-32(29-35)39-34(37)28-25-22-19-16-13-11-9-10-12-15-17-20-23-26-31(2)3/h31-32,35H,4-30H2,1-3H3 ChemAxon inchikey QJPLJPKQDLVDLD-UHFFFAOYSA-N ChemAxon polar_surface_area 72.83 ChemAxon refractivity 163.05 ChemAxon polarizability 73.32 ChemAxon rotatable_bond_count 32 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon phospholipid biosynthesis (CL(12:0/19:iso/12:0/19:iso)) Phospholipids are membrane components in E. coli. The major phospholipids of E. coli are phosphatidylethanolamine, phosphatidylglycerol and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty acids at the sn-1 and sn-2 positions. The reaction starts from a glycerone phosphate (dihydroxyacetone phosphate) produced in glycolysis. The glycerone phosphate is transformed to a sn-glycerol 3-phosphate (glycerol 3 phosphate) by NADPH driven glycerol-3-phosphate dehydrogenase. Sn-glycerol 3-phosphate is transformed to a 1-acyl-sn-glycerol 3-phosphate(1-oleyl-2-lyso-phosphatidate , 1-palmitoylglycerol 3-phosphate , 1-stearoyl-sn-glycerol 3-phosphate). This can be achieve by a sn-glycerol-3-phosphate 1-0-acyltransferase that interacts either with a long-chain acyl-CoA or with an acyl-[acp]. The 1-acyl-sn-glycerol 3-phosphate is transformed into a 1,2-diacyl-sn-glycerol 3-phosphate through a 1-acylglycerol-3-phosphate O-acyltransferase. This compound is then converted into a CPD-diacylglycerol through a CTP (phosphatidate cytididyltransferase. CPD-diacylglycerol can be transformed either to a L-1-phosphatidylserine or a L-1-phosphatidylglycerol-phosphate through a phosphatidylserine synthase or a phosphatidylglycerophosphate synthase respectively. The L-1-phosphatidylserine transforms into L-1-phosphatidylethanolamine through a phosphatidylserine decarboxylase, o the other hand L-1-phosphatidylglycerol-phosphate gets transformed into a L-1-phosphatidyl-glycerol through a phosphatidylglycerophosphatase. These 2 products combines produce a cardiolipin and a ethanolamine. The L-1 phosphatidyl-glycerol can also interact with cardiolipin synthase resulting in a glycerol and a cardiolipin. PW001933 Metabolic Specdb::CMs 1089657 Specdb::NmrOneD 331162 Specdb::NmrOneD 331163 Specdb::NmrOneD 331164 Specdb::NmrOneD 331165 Specdb::NmrOneD 331166 Specdb::NmrOneD 331167 Specdb::NmrOneD 331168 Specdb::NmrOneD 331169 Specdb::NmrOneD 331170 Specdb::NmrOneD 331171 Specdb::NmrOneD 331172 Specdb::NmrOneD 331173 Specdb::NmrOneD 331174 Specdb::NmrOneD 331175 Specdb::NmrOneD 331176 Specdb::NmrOneD 331177 Specdb::NmrOneD 331178 Specdb::NmrOneD 331179 Specdb::NmrOneD 331180 Specdb::NmrOneD 331181 Specdb::MsMs 25703 Specdb::MsMs 25704 Specdb::MsMs 25705 Specdb::MsMs 32261 Specdb::MsMs 32262 Specdb::MsMs 32263 Yurtsever D. (2007). Fatty acid methyl ester profiling of Enterococcus and Esherichia coli for microbial source tracking. M.sc. Thesis. Villanova University: U.S.A Phosphatidate cytidylyltransferase P0ABG1 CDSA_ECOLI cdsA http://ecmdb.ca/proteins/P0ABG1.xml 2 DG(12:0/19:iso/0:0) + Cytidine triphosphate + Hydrogen ion >2 CDP-DG(12:0/19:iso) + Pyrophosphate PW_R005421