2.02015-06-11 10:46:25 -06002015-08-05 16:22:05 -0600ECMDB23898M2MDB005689L-OrnithineAn optically active form of ornithine having L-configuration(S)-2,5-Diaminopentanoate(S)-2,5-Diaminopentanoic acid(S)-2,5-Diaminovalerate(S)-2,5-Diaminovaleric acidC5H12N2O2132.161132.089877638(2S)-2,5-diaminopentanoic acidornithine70-26-8NCCC[C@H](N)C(O)=OInChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1AHLPHDHHMVZTML-BYPYZUCNSA-Nlogp-3.64logs0.11solubility1.72e+02 g/llogp-3.7pka_strongest_acidic2.67pka_strongest_basic10.29iupac(2S)-2,5-diaminopentanoic acidaverage_mass132.161mono_mass132.089877638smilesNCCC[C@H](N)C(O)=OformulaC5H12N2O2inchiInChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1inchikeyAHLPHDHHMVZTML-BYPYZUCNSA-Npolar_surface_area89.34refractivity33.21polarizability13.85rotatable_bond_count4acceptor_count4donor_count3physiological_charge1formal_charge0Glutathione metabolismThe biosynthesis of glutathione starts with the introduction of L-glutamic acid through either a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a
glutamate / aspartate ABC transporter. Once in the cytoplasm, L-glutamice acid reacts with L-cysteine through an ATP glutamate-cysteine ligase resulting in gamma-glutamylcysteine. This compound reacts which Glycine through an ATP driven glutathione synthetase thus catabolizing Glutathione.
This compound is metabolized through a spontaneous reaction with an oxidized glutaredoxin resulting in a reduced glutaredoxin and an oxidized glutathione. This compound is reduced by a NADPH glutathione reductase resulting in a glutathione.
PW000833ec00480MetabolicArginine and proline metabolismec00330Metabolic pathwayseco01100Specdb::CMs472Specdb::CMs473Specdb::CMs474Specdb::CMs1291Specdb::CMs1415Specdb::CMs1484Specdb::CMs1750Specdb::CMs2994Specdb::CMs30085Specdb::CMs30379Specdb::CMs30606Specdb::CMs30798Specdb::CMs31079Specdb::CMs31080Specdb::CMs31081Specdb::CMs31082Specdb::CMs31791Specdb::CMs32270Specdb::CMs32271Specdb::CMs32273Specdb::CMs37363Specdb::CMs130647Specdb::CMs138381Specdb::CMs1054761Specdb::CMs1054763Specdb::NmrOneD1206Specdb::NmrOneD1207Specdb::NmrOneD4859Specdb::NmrOneD6152Specdb::NmrOneD6153Specdb::NmrOneD6154Specdb::NmrOneD6155Specdb::NmrOneD6156Specdb::NmrOneD6157Specdb::NmrOneD6158Specdb::NmrOneD6159Specdb::NmrOneD6160Specdb::NmrOneD6161Specdb::NmrOneD6162Specdb::NmrOneD6163Specdb::NmrOneD6164Specdb::NmrOneD6165Specdb::NmrOneD6166Specdb::NmrOneD6167Specdb::NmrOneD6168Specdb::NmrOneD6169Specdb::NmrOneD6170Specdb::NmrOneD6171Specdb::NmrOneD166442Specdb::MsMs349Specdb::MsMs350Specdb::MsMs351Specdb::MsMs3635Specdb::MsMs3636Specdb::MsMs3637Specdb::MsMs3638Specdb::MsMs3639Specdb::MsMs3640Specdb::MsMs3641Specdb::MsMs3642Specdb::MsMs3643Specdb::MsMs3644Specdb::MsMs3645Specdb::MsMs3646Specdb::MsMs3647Specdb::MsMs3648Specdb::MsMs3649Specdb::MsMs3650Specdb::MsMs3651Specdb::MsMs3652Specdb::MsMs3653Specdb::MsMs179271Specdb::MsMs179272Specdb::MsMs179273Specdb::NmrTwoD996Specdb::NmrTwoD1212C00077Ornithine carbamoyltransferase chain IP04391OTC1_ECOLIargIhttp://ecmdb.ca/proteins/P04391.xmlOrnithine carbamoyltransferase chain FP06960OTC2_ECOLIargFhttp://ecmdb.ca/proteins/P06960.xmlOrnithine decarboxylase, constitutiveP21169DCOR_ECOLIspeChttp://ecmdb.ca/proteins/P21169.xmlAcetylornithine deacetylaseP23908ARGE_ECOLIargEhttp://ecmdb.ca/proteins/P23908.xmlOrnithine decarboxylase, inducibleP24169DCOS_ECOLIspeFhttp://ecmdb.ca/proteins/P24169.xmlN-Acetylornithine + Water <> Acetic acid + Ornithine + L-OrnithineR00669ACETYLORNDEACET-RXNCarbamoylphosphate + Ornithine + L-Ornithine <> Citrulline + Hydrogen ion + PhosphateR01398ORNCARBAMTRANSFER-RXNHydrogen ion + Ornithine + L-Ornithine <> Carbon dioxide + Putrescine + EthylenediamineR00670ORNDECARBOX-RXNCarbamoylphosphate + Ornithine + L-Ornithine <> Citrulline + Hydrogen ion + PhosphateHydrogen ion + Ornithine + L-Ornithine <> Carbon dioxide + Putrescine + EthylenediamineN-Acetylornithine + Water <> Acetic acid + Ornithine + L-OrnithineN-Acetylornithine + Water <> Acetic acid + Ornithine + L-Ornithine