2.02015-06-08 15:34:32 -06002015-08-05 16:22:05 -0600ECMDB23871M2MDB005537Orthophosphoric monoesterAn organic phosphate that is phosphoric acid in which one of the hydrogens is replaced by an organyl group2-HydroxycyclohexanoneAdipoinC6H10O2114.144114.0680795622-hydroxycyclohexan-1-one2-hydroxycyclohexanoneOC1CCCCC1=OInChI=1S/C6H10O2/c7-5-3-1-2-4-6(5)8/h5,7H,1-4H2ODZTXUXIYGJLMC-UHFFFAOYSA-Nlogp-0.08logs0.25solubility2.01e+02 g/llogp0.62pka_strongest_acidic13.41pka_strongest_basic-3.5iupac2-hydroxycyclohexan-1-oneaverage_mass114.144mono_mass114.068079562smilesOC1CCCCC1=OformulaC6H10O2inchiInChI=1S/C6H10O2/c7-5-3-1-2-4-6(5)8/h5,7H,1-4H2inchikeyODZTXUXIYGJLMC-UHFFFAOYSA-Npolar_surface_area37.3refractivity29.74polarizability12.01rotatable_bond_count0acceptor_count2donor_count1physiological_charge0formal_charge0gamma-Hexachlorocyclohexane degradationec00361Folate biosynthesisThe biosynthesis of folic acid begins with a product of purine nucleotides de novo biosynthesis pathway, GTP. This compound is involved in a reaction with water through a GTP cyclohydrolase 1 protein complex, resulting in a hydrogen ion, formic acid and 7,8-dihydroneopterin 3-triphosphate. The latter compound is dephosphatased through a dihydroneopterin triphosphate pyrophosphohydrolase resulting in the release of a pyrophosphate, hydrogen ion and 7,8-dihydroneopterin 3-phosphate. The latter compound reacts with water spontaneously resulting in the release of a phosphate and a 7,8 -dihydroneopterin. This compound reacts with a dihydroneopterin aldolase, releasing a glycoaldehyde and 6-hydroxymethyl-7,9-dihydropterin. The latter compound is phosphorylated with a ATP-driven 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase resulting in a (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
Chorismate is metabolized by reacting with L-glutamine through a 4-amino-4-deoxychorismate synthase resulting in L-glutamic acid and 4-amino-4-deoxychorismate. The latter compound then reacts through an aminodeoxychorismate lyase resulting in pyruvic acid,hydrogen ion and p-aminobenzoic acid.
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate and p-aminobenzoic acid react through a dihydropteroate synthase resulting in pyrophosphate and 7,8-dihydropteroic acid. This compound reacts with L-glutamic acid through an ATP driven bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase resulting in a 7,8-dihydrofolate monoglutamate. This compound is reduced through an NADPH mediated dihydrofolate reductase resulting in a tetrahydrofate.
This product goes on to a one carbon pool by folate pathway.
PW000908ec00790MetabolicInositol phosphate metabolismec00562Riboflavin metabolismec007401,4-Dichlorobenzene degradationec00627Microbial metabolism in diverse environmentsec01120Metabolic pathwayseco01100Specdb::CMs1085195Specdb::MsMs29402Specdb::MsMs29403Specdb::MsMs29404Specdb::MsMs35960Specdb::MsMs35961Specdb::MsMs35962C01153Orthophosphoric monoester + Water <> Alcohol + PhosphateR00626