2.02015-06-04 15:17:12 -06002015-08-05 16:22:04 -0600ECMDB23788M2MDB004318SelenateA divalent inorganic anion obtained by removal of both protons from selenic acidH2SEO4SelenateSelenic acid[SeO2(OH)2]H2O4Se144.97145.91183038selenic acidselenic acid7783-08-6O[Se](O)(=O)=OInChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)QYHFIVBSNOWOCQ-UHFFFAOYSA-Nlogp-1.6pka_strongest_acidic-3.8iupacselenic acidaverage_mass144.97mono_mass145.91183038smilesO[Se](O)(=O)=OformulaH2O4SeinchiInChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)inchikeyQYHFIVBSNOWOCQ-UHFFFAOYSA-Npolar_surface_area74.6refractivity21.13polarizability6.65rotatable_bond_count0acceptor_count5donor_count2physiological_charge-2formal_charge0Selenoamino acid metabolismec00450Selenium metabolismThe selenium metabolism begins with the introduction of selenate and selenite to the cytosol through a sulphate permease system. Once in the cell, selenate can be reduced to selenite through nitrate reductases A and Z. Selenite then interacts with glutathione and 2 hydrogen ions resulting in the release of 2 water molecules, a hydroxide molecule, a glutathione disulfide and a selenodiglutathione. The latter compound then reacts with NADPH+H resulting in the release of a NADP, a glutathione and a glutathioselenol.
Glutathiolselenol can then be oxidize resulting in a a glutathiolselenol ion which can then interact with a water molecule resulting in a release of glutathion and selenium
Glutathiolselenol can also react with NADPH and hydrogen ion resulting in a release of glutathione, NADP, a hydroxide molecule and a hydrogen selenide. This compound can react in a reversible reaction by being oxidized resulting in a hydrogen selenide ion . This compound can then be phosphorylated by interacting with an ATP and releasing a AMP, a phosphate and a selenophosphate.PW001894Metabolicinner membrane transportlist of inner membrane transport complexes, transporting compounds from the periplasmic space to the cytosol
This pathway should be updated regularly with the new inner membrae transports addedPW000786MetabolicSpecdb::CMs35605Specdb::CMs155323Specdb::MsMs29315Specdb::MsMs29316Specdb::MsMs29317Specdb::MsMs35873Specdb::MsMs35874Specdb::MsMs35875Specdb::MsMs2754319Specdb::MsMs2754320Specdb::MsMs2754321Specdb::MsMs2951412Specdb::MsMs2951413Specdb::MsMs2951414C05697Respiratory nitrate reductase 1 alpha chainP09152NARG_ECOLInarGhttp://ecmdb.ca/proteins/P09152.xmlRespiratory nitrate reductase 2 gamma chainP0AF32NARV_ECOLInarVhttp://ecmdb.ca/proteins/P0AF32.xmlRespiratory nitrate reductase 1 beta chainP11349NARH_ECOLInarHhttp://ecmdb.ca/proteins/P11349.xmlRespiratory nitrate reductase 1 gamma chainP11350NARI_ECOLInarIhttp://ecmdb.ca/proteins/P11350.xmlProbable nitrate reductase molybdenum cofactor assembly chaperone NarWP19317NARW_ECOLInarWhttp://ecmdb.ca/proteins/P19317.xmlRespiratory nitrate reductase 2 beta chainP19318NARY_ECOLInarYhttp://ecmdb.ca/proteins/P19318.xmlRespiratory nitrate reductase 2 alpha chainP19319NARZ_ECOLInarZhttp://ecmdb.ca/proteins/P19319.xmlSulfate adenylyltransferase subunit 2P21156CYSD_ECOLIcysDhttp://ecmdb.ca/proteins/P21156.xmlSulfate adenylyltransferase subunit 1P23845CYSN_ECOLIcysNhttp://ecmdb.ca/proteins/P23845.xmlPeriplasmic nitrate reductaseP33937NAPA_ECOLInapAhttp://ecmdb.ca/proteins/P33937.xmlDiheme cytochrome c napBP0ABL3NAPB_ECOLInapBhttp://ecmdb.ca/proteins/P0ABL3.xmlNitrate reductase molybdenum cofactor assembly chaperone NarJP0AF26NARJ_ECOLInarJhttp://ecmdb.ca/proteins/P0AF26.xmlSelenite + Water + Acceptor <> Selenate + Reduced acceptorR07229 Selenate + 2 Hydrogen ion + 2 Electron > Selenite + WaterPW_R005187