Ubiquinol-1 (ECMDB21574) (M2MDB001968)

General function:

Involved in magnesium ion binding

Specific function:

Pyruvate + ferricytochrome b1 + H(2)O = acetate + CO(2) + ferrocytochrome b1

Gene Name:

poxB

Uniprot ID:

P07003

Molecular weight:

62011

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhB

Uniprot ID:

P07014

Molecular weight:

26770

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon

Gene Name:

putA

Uniprot ID:

P09546

Molecular weight:

143814

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

sn-glycerol 3-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H

Gene Name:

gpsA

Uniprot ID:

P0A6S7

Molecular weight:

36361

Reactions

General function:

Involved in catalytic activity

Specific function:

(S)-dihydroorotate + a quinone = orotate + a quinol

Gene Name:

pyrD

Uniprot ID:

P0A7E1

Molecular weight:

36774

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhA

Uniprot ID:

P0AC41

Molecular weight:

64421

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhD

Uniprot ID:

P0AC44

Molecular weight:

12867

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoA

Uniprot ID:

P0AFC3

Molecular weight:

16457

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoB

Uniprot ID:

P0AFC7

Molecular weight:

25056

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoE

Uniprot ID:

P0AFD1

Molecular weight:

18590

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone

Gene Name:

nuoH

Uniprot ID:

P0AFD4

Molecular weight:

36219

Reactions

General function:

Involved in electron carrier activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoI

Uniprot ID:

P0AFD6

Molecular weight:

20538

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoJ

Uniprot ID:

P0AFE0

Molecular weight:

19874

Reactions

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

There are 2 NADH dehydrogenases in E.coli, however only this complex is able to use dNADH (reduced nicotinamide hypoxanthine dinucleotide, deamino-NADH) and dNADH-DB (dimethoxy- 5-methyl-6-decyl-1,4-benzoquinone) as substrates

Gene Name:

nuoK

Uniprot ID:

P0AFE4

Molecular weight:

10845

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoM

Uniprot ID:

P0AFE8

Molecular weight:

56524

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoN

Uniprot ID:

P0AFF0

Molecular weight:

52044

Reactions

General function:

Involved in oxidoreductase activity, acting on CH-OH group of donors

Specific function:

GDH is probably involved in energy conservation rather than in sugar metabolism

Gene Name:

gcd

Uniprot ID:

P15877

Molecular weight:

86747

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoF

Uniprot ID:

P31979

Molecular weight:

49292

Reactions

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoC

Uniprot ID:

P33599

Molecular weight:

68236

Reactions

General function:

Involved in electron carrier activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoG

Uniprot ID:

P33602

Molecular weight:

100298

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient

Gene Name:

nuoL

Uniprot ID:

P33607

Molecular weight:

66438

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhC

Uniprot ID:

P69054

Molecular weight:

14299

General function:

Involved in cytochrome bo3 ubiquinol oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration

Gene Name:

cyoA

Uniprot ID:

P0ABJ1

Molecular weight:

34911

Reactions

General function:

Involved in cytochrome o ubiquinol oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration

Gene Name:

cyoD

Uniprot ID:

P0ABJ6

Molecular weight:

12029

General function:

Involved in oxidation-reduction process

Specific function:

Cytochrome oxidase subunit

Gene Name:

appB

Uniprot ID:

P26458

Molecular weight:

42423

General function:

Energy production and conversion

Specific function:

Cytochrome oxidase subunit

Gene Name:

appC

Uniprot ID:

P26459

Molecular weight:

57919

General function:

Involved in oxidation-reduction process

Specific function:

Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration

Gene Name:

cydB

Uniprot ID:

P0ABK2

Molecular weight:

42453

Reactions

General function:

Involved in cytochrome-c oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer

Gene Name:

cyoB

Uniprot ID:

P0ABI8

Molecular weight:

74367

Reactions

General function:

Energy production and conversion

Specific function:

Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration

Gene Name:

cydA

Uniprot ID:

P0ABJ9

Molecular weight:

58205

Reactions

General function:

Involved in heme-copper terminal oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration

Gene Name:

cyoC

Uniprot ID:

P0ABJ3

Molecular weight:

22623

Reactions

General function:

oxidative phosphorylation

Specific function:

Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap.

Gene Name:

cydX

Uniprot ID:

P56100

Molecular weight:

4041