Nickel (ECMDB21391) (M2MDB001786)
| Record Information | ||||||||||||||||||||||||||||||||||||||||||||||
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| Version | 2.0 | |||||||||||||||||||||||||||||||||||||||||||||
| Creation Date | 2012-07-30 14:55:41 -0600 | |||||||||||||||||||||||||||||||||||||||||||||
| Update Date | 2015-09-13 15:15:32 -0600 | |||||||||||||||||||||||||||||||||||||||||||||
| Secondary Accession Numbers |
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| Identification | ||||||||||||||||||||||||||||||||||||||||||||||
| Name: | Nickel | |||||||||||||||||||||||||||||||||||||||||||||
| Description | Nickel is a solid, silver-white, hard, malleable transition metal with an atomic number of 28. It resists corrosion even at high temperatures. It is present in many alloys in widespread use, including stainless steels. It may also be present as an impurity in any alloy. Nickel is used in the production of coins, jewellery, and nickel-cadmium batteries, and as a catalyst for the hydrogenation of liquid oils to solid fats such as oleomargarine and vegetable shortening. Nickel-containing dental alloys continue to be used successfully in the provision of various forms of dental care. Many of these alloys have applications in the construction of restorations designed to remain in clinical service for many years, including crowns, fixed bridgework, and removable partial dentures. Furthermore, nickel containing alloys find extensive application in orthodontics, including metallic brackets, arch wires, bands, springs and ligature wires. Many instruments and devises, for example, endodontic instruments also contain nickel. | |||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | |||||||||||||||||||||||||||||||||||||||||||||
| Synonyms: |
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| Chemical Formula: | Ni | |||||||||||||||||||||||||||||||||||||||||||||
| Weight: | Average: 58.6934 Monoisotopic: 57.935347922 | |||||||||||||||||||||||||||||||||||||||||||||
| InChI Key: | VEQPNABPJHWNSG-UHFFFAOYSA-N | |||||||||||||||||||||||||||||||||||||||||||||
| InChI: | InChI=1S/Ni/q+2 | |||||||||||||||||||||||||||||||||||||||||||||
| CAS number: | 7440-02-0 | |||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name: | nickel(2+) ion | |||||||||||||||||||||||||||||||||||||||||||||
| Traditional IUPAC Name: | nickel(2+) ion | |||||||||||||||||||||||||||||||||||||||||||||
| SMILES: | [Ni++] | |||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | ||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. | |||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Inorganic compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Homogeneous metal compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Class | Homogeneous transition metal compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Homogeneous transition metal compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents | ||||||||||||||||||||||||||||||||||||||||||||||
| Substituents |
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| Molecular Framework | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
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| Physical Properties | ||||||||||||||||||||||||||||||||||||||||||||||
| State: | Solid | |||||||||||||||||||||||||||||||||||||||||||||
| Charge: | 2 | |||||||||||||||||||||||||||||||||||||||||||||
| Melting point: | 1455 °C | |||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties: |
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| Predicted Properties |
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| Biological Properties | ||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations: | Cytoplasm | |||||||||||||||||||||||||||||||||||||||||||||
| Reactions: | Adenosine triphosphate + Water + Nickel > ADP + Hydrogen ion + Nickel + Phosphate Adenosine triphosphate + Water + Nickel > ADP + Hydrogen ion + Nickel + Phosphate Adenosine triphosphate + Water + Nickel > ADP + Inorganic phosphate + Nickel Adenosine triphosphate + Water + Nickel > ADP + Inorganic phosphate + Nickel | |||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways: | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| KEGG Pathways: | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| EcoCyc Pathways: | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| Concentrations | ||||||||||||||||||||||||||||||||||||||||||||||
| Not Available | ||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | ||||||||||||||||||||||||||||||||||||||||||||||
| Spectra: |
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| References | ||||||||||||||||||||||||||||||||||||||||||||||
| References: |
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| Synthesis Reference: | Lightner, David A.; Crist, B. Vincent; Kalyanam, Nagabushanam; May, Leslie M.; Jackman, Dennis E. The octant rule. 15. Antioctant effects: synthesis and circular dichroism of 2-exo- and 2-endo-alkylbicyclo[2.2.1]heptan-7-ones and bicyclo[3.2.1]octan-8-one | |||||||||||||||||||||||||||||||||||||||||||||
| Material Safety Data Sheet (MSDS) | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| Links | ||||||||||||||||||||||||||||||||||||||||||||||
| External Links: |
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Enzymes
- General function:
- Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
- Specific function:
- Mediates magnesium influx to the cytosol
- Gene Name:
- mgtA
- Uniprot ID:
- P0ABB8
- Molecular weight:
- 99466
Reactions
| ATP + H(2)O + Mg(2+)(Out) = ADP + phosphate + Mg(2+)(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Involved in export of lead, cadmium, zinc and mercury
- Gene Name:
- zntA
- Uniprot ID:
- P37617
- Molecular weight:
- 76839
Reactions
| ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out). |
| ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out). |
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikC
- Uniprot ID:
- P0AFA9
- Molecular weight:
- 30362
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikB
- Uniprot ID:
- P33591
- Molecular weight:
- 35248
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably represents the nickel binder
- Gene Name:
- nikA
- Uniprot ID:
- P33590
- Molecular weight:
- 58718
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikD
- Uniprot ID:
- P33593
- Molecular weight:
- 26820
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikE
- Uniprot ID:
- P33594
- Molecular weight:
- 29721
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
Transporters
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikC
- Uniprot ID:
- P0AFA9
- Molecular weight:
- 30362
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
- Gene Name:
- nikB
- Uniprot ID:
- P33591
- Molecular weight:
- 35248
- General function:
- Involved in cation transmembrane transporter activity
- Specific function:
- Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas zntA is required for growth at more toxic concentrations
- Gene Name:
- zitB
- Uniprot ID:
- P75757
- Molecular weight:
- 34678
- General function:
- Involved in transporter activity
- Specific function:
- Involved in a nickel transport system, probably represents the nickel binder
- Gene Name:
- nikA
- Uniprot ID:
- P33590
- Molecular weight:
- 58718
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in cation transmembrane transporter activity
- Specific function:
- Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton- dependent manner
- Gene Name:
- fieF
- Uniprot ID:
- P69380
- Molecular weight:
- 32927
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikD
- Uniprot ID:
- P33593
- Molecular weight:
- 26820
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in cobalt ion transmembrane transporter activity
- Specific function:
- Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake
- Gene Name:
- corA
- Uniprot ID:
- P0ABI4
- Molecular weight:
- 36589
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
- Gene Name:
- nikE
- Uniprot ID:
- P33594
- Molecular weight:
- 29721
Reactions
| ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). |
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368