2.0 2012-07-30 14:55:06 -0600 2015-06-03 17:21:00 -0600 ECMDB21246 M2MDB001654 Molybdate Molybdate is a compound containing an oxoanion with molybdenum in its highest oxidation state of 6. Molybdenum can form a very large range of such oxoanions which can be discrete structures or polymeric extended structures, although the latter are only found in the solid state.The larger oxoanions are members of group of compounds termed polyoxometalates, and because they contain only one type of metal atom are often called isopolymetalates. The discrete molybdenum oxoanions range in size from the simplest MoO42_, found in potassium molybdate up to extremely large structures found in isopoly-molybdenum blues that contain for example 154 Mo atoms. The behaviour of molybdenum is different from the other elements in group 6. Molybdate is involved in the molybdenum cofactor biosynthesis pathway. Molybdate reacts with molybdopterin-AMP to produce molybdenum cofactor, AMP, and H2O. Molybdate Molybdate ion Molybdates Molybdic acid Molybdic acid ion MoO4-2 MoO42- MoO₄^-2 MoO₄^2- Tetraoxidomolybdate(2) Tetraoxidomolybdate(6) Tetraoxidomolybdic acid(2) Tetraoxidomolybdic acid(6) [MoO4]2 H2MoO4 161.95 163.900716398 dihydroxydioxomolybdenumbis(ylium) dihydroxydioxomolybdenumbis(ylium) 14259-85-9 O[Mo](O)(=O)=O InChI=1S/Mo.2H2O.2O/h;2*1H2;;/q+2;;;;/p-2 VLAPMBHFAWRUQP-UHFFFAOYSA-L Solid Cytosol Extra-organism Periplasm logp -1.8 ChemAxon pka_strongest_acidic -2.3 ChemAxon iupac dihydroxydioxomolybdenumbis(ylium) ChemAxon average_mass 161.95 ChemAxon mono_mass 163.900716398 ChemAxon smiles O[Mo](O)(=O)=O ChemAxon formula H2MoO4 ChemAxon inchi InChI=1S/Mo.2H2O.2O/h;2*1H2;;/q+2;;;;/p-2 ChemAxon inchikey VLAPMBHFAWRUQP-UHFFFAOYSA-L ChemAxon polar_surface_area 74.6 ChemAxon refractivity 8.02 ChemAxon polarizability 6.51 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 2 ChemAxon ABC transporters ec02010 GTP degradation GTP, produced in the nucleotide de novo biosyntheis pathway, interacts with a water molecule through a GTP cyclohydrolase resulting in a formate, hydrogen ion and a 7,8-dihydroneopterin 3'-triphosphate. The latter compound interacts with a water molecule through a dihydroneopterin triphosphate pyrophosphohydrolase resulting in the release of a pyrophosphate, a hydrogen ion and a 7,8-dihydroneopterin 3'-phosphate. The latter compound interacts with water spontaneously resulting in the release of a phosphate and a 7,8 dihydroneopterin. The latter compound interacts with a dihydroneopterin aldolase resulting in the release of a glycolaldehyde and a 6-hydroxymethyl-7,8-dihydropterin. This compound then is then diphosphorylated by reacting with a ATP driven 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase resulting in the release of a hydrogen ion, an AMP and 6-hydroxymethyl-7,8-dihydropterin diphosphate. GTP interacts with a cyclic pyranopterin monophosphate synthase resulting in the release of a diphosphate and a cyclic pyranopterin phosphate. The latter compound interacts with a thiocarboxylated small subunit of molybdopterin synthase (a protein) and a water molecule through a molybdopterin synthase resulting in the release of 4 hydrogen ions, 2 small subunits of molybdopterin synthase and a molybdopterin. The molybdopterin interacts with an ATP and a hydrogen ion through a molybdopterin adenylyltransferase resulting in the release of a diphosphate and a molybdopterin adenine dinucleotide. PW001888 Metabolic molybdenum cofactor biosynthesis PWY-6823 HMDB12260 24621 23023 C06232 36264 CPD-3 Molybdate Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Sulfate/thiosulfate import ATP-binding protein cysA P16676 CYSA_ECOLI cysA http://ecmdb.ca/proteins/P16676.xml Sulfate transport system permease protein cysW P0AEB0 CYSW_ECOLI cysW http://ecmdb.ca/proteins/P0AEB0.xml Molybdenum transport system permease protein modB P0AF01 MODB_ECOLI modB http://ecmdb.ca/proteins/P0AF01.xml Sulfate transport system permease protein cysT P16701 CYST_ECOLI cysU http://ecmdb.ca/proteins/P16701.xml Sulfate-binding protein P0AG78 SUBI_ECOLI sbp http://ecmdb.ca/proteins/P0AG78.xml Molybdopterin molybdenumtransferase P12281 MOEA_ECOLI moeA http://ecmdb.ca/proteins/P12281.xml Thiosulfate-binding protein P16700 CYSP_ECOLI cysP http://ecmdb.ca/proteins/P16700.xml Molybdenum import ATP-binding protein ModC P09833 MODC_ECOLI modC http://ecmdb.ca/proteins/P09833.xml Molybdate-binding periplasmic protein P37329 MODA_ECOLI modA http://ecmdb.ca/proteins/P37329.xml Sulfate/thiosulfate import ATP-binding protein cysA P16676 CYSA_ECOLI cysA http://ecmdb.ca/proteins/P16676.xml Sulfate transport system permease protein cysW P0AEB0 CYSW_ECOLI cysW http://ecmdb.ca/proteins/P0AEB0.xml Molybdenum transport system permease protein modB P0AF01 MODB_ECOLI modB http://ecmdb.ca/proteins/P0AF01.xml Sulfate transport system permease protein cysT P16701 CYST_ECOLI cysU http://ecmdb.ca/proteins/P16701.xml Sulfate-binding protein P0AG78 SUBI_ECOLI sbp http://ecmdb.ca/proteins/P0AG78.xml Outer membrane protein N P77747 OMPN_ECOLI ompN http://ecmdb.ca/proteins/P77747.xml Thiosulfate-binding protein P16700 CYSP_ECOLI cysP http://ecmdb.ca/proteins/P16700.xml Outer membrane pore protein E P02932 PHOE_ECOLI phoE http://ecmdb.ca/proteins/P02932.xml Outer membrane protein F P02931 OMPF_ECOLI ompF http://ecmdb.ca/proteins/P02931.xml Molybdenum import ATP-binding protein ModC P09833 MODC_ECOLI modC http://ecmdb.ca/proteins/P09833.xml Outer membrane protein C P06996 OMPC_ECOLI ompC http://ecmdb.ca/proteins/P06996.xml Molybdate-binding periplasmic protein P37329 MODA_ECOLI modA http://ecmdb.ca/proteins/P37329.xml Adenosine triphosphate + Water + Molybdate > ADP + Hydrogen ion + Molybdate + Phosphate ABC-19-RXN Adenosine triphosphate + Water + Molybdate > ADP + Hydrogen ion + Molybdate + Phosphate ABC-19-RXN 2 Hydrogen ion + Molybdate + Adenylated molybdopterin > Adenosine monophosphate + Copper + Water + Molybdopterin Adenylated molybdopterin + Molybdate <> Molybdoenzyme molybdenum cofactor + Adenosine monophosphate + Water + Molybdoenzyme molybdenum cofactor R09735 Adenosine triphosphate + Molybdate + Water > ADP + Phosphate + Molybdate + Hydrogen ion ABC-19-RXN Adenosine triphosphate + Molybdate + Water > ADP + Phosphate + Molybdate + Hydrogen ion ABC-19-RXN Adenylated molybdopterin + Molybdate > molybdenum cofactor + Adenosine monophosphate + Water RXN-8348 Adenosine triphosphate + Water + Molybdate > ADP + Inorganic phosphate + Molybdate Adenosine triphosphate + Water + Molybdate > ADP + Inorganic phosphate + Molybdate Adenylyl-molybdopterin + Molybdate > Molybdopterin + Adenosine monophosphate ADP + Phosphate + 4 Hydrogen ion + Heme + Nickel(2+) + Iron chelate + Taurine + Molybdate + Magnesium + Fe3+ + Potassium + Polyamine + vitamin B12 + Sulfate + glycerol-3-phosphate + Phosphonate + D-Maltose <> Adenosine triphosphate +3 Hydrogen ion + Water R00086 RXN0-1061 Adenylyl-molybdopterin + Hydrogen ion + Molybdate > Adenosine monophosphate + Water + molybdenum cofactor PW_R005941