L-Alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine (ECMDB21239) (M2MDB001647)

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling

Gene Name:

amiB

Uniprot ID:

P26365

Molecular weight:

47985

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides

Gene Name:

amiA

Uniprot ID:

P36548

Molecular weight:

31412

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling

Gene Name:

amiC

Uniprot ID:

P63883

Molecular weight:

45634

Reactions

General function:

Defense mechanisms

Specific function:

Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the lcdA reaction can then be reused as peptidoglycan building blocks; lcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase

Gene Name:

ldcA

Uniprot ID:

P76008

Molecular weight:

33567

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

oppB

Uniprot ID:

P0AFH2

Molecular weight:

33443

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

oppC

Uniprot ID:

P0AFH6

Molecular weight:

33022

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system

Gene Name:

oppF

Uniprot ID:

P77737

Molecular weight:

37197

General function:

Involved in transporter activity

Specific function:

This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity

Gene Name:

oppA

Uniprot ID:

P23843

Molecular weight:

60899

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system

Gene Name:

oppD

Uniprot ID:

P76027

Molecular weight:

37188

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety

Gene Name:

ampD

Uniprot ID:

P13016

Molecular weight:

20536

Reactions

General function:

Involved in ATP binding

Specific function:

Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid

Gene Name:

mpl

Uniprot ID:

P37773

Molecular weight:

49874