KDO(2)-lipid IV(A) (ECMDB21235) (M2MDB001643)

General function:

Involved in biosynthetic process

Specific function:

Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA. Degraded by FtsH; therefore FtsH regulates the addition of the sugar moiety of the LPS and thus the maturation of the LPS precursor

Gene Name:

waaA

Uniprot ID:

P0AC75

Molecular weight:

47291

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA. Has 10 fold selectivity for lauroyl- ACP over myristoyl-ACP

Gene Name:

htrB

Uniprot ID:

P0ACV0

Molecular weight:

35407

General function:

Involved in transferase activity, transferring pentosyl groups

Specific function:

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnT

Uniprot ID:

P76473

Molecular weight:

62542

Reactions

General function:

Involved in lipopolysaccharide transport

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptG

Uniprot ID:

P0ADC6

Molecular weight:

39618

General function:

Involved in lipopolysaccharide-transporting ATPase acti

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptF

Uniprot ID:

P0AF98

Molecular weight:

40357

General function:

Involved in nucleotide binding

Specific function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Gene Name:

msbA

Uniprot ID:

P60752

Molecular weight:

64460

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Specific function unknown

Gene Name:

ddg

Uniprot ID:

P0ACV2

Molecular weight:

35493

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system

Gene Name:

lptB

Uniprot ID:

P0A9V1

Molecular weight:

26800

General function:

Involved in lipopolysaccharide transmembrane transporter activity

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptC

Uniprot ID:

P0ADV9

Molecular weight:

21703

General function:

Involved in lipopolysaccharide binding

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain of LPS

Gene Name:

lptA

Uniprot ID:

P0ADV1

Molecular weight:

20127