| Record Information |
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| Version | 2.0 |
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| Creation Date | 2012-07-30 14:54:49 -0600 |
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| Update Date | 2015-09-13 12:56:14 -0600 |
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| Secondary Accession Numbers | |
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| Identification |
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| Name: | Calcium |
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| Description | Calcium is a chemical element with symbol Ca and atomic number 20. Calcium is the fifth-most-abundant dissolved ion in seawater by both molarity and mass, after sodium, chloride, magnesium, and sulfate. Calcium is essential for living organisms, in particular in cell physiology, where movement of the calcium ion Ca2+ into and out of cells functions as a signal for many cellular processes. (Wikipedia, KEGG) The Ca2+ ion activates, inhibits, and acts as a cofactor for a wide variety of enzymes in E. coli. It is also found in many types of E. coli growth media. (EcoCyc) |
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| Structure | |
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| Synonyms: | - 20Ca
- Ca
- Calcio
- Calcium
- Calcium cation
- Calcium element
- Calcium ion
- Calcium(2+)
- Edetate calcium disodium anhydrous
- Edetic acid calcium disodium anhydrous
- Kalzium
- Sodium calcium edetate
- Sodium calcium edetic acid
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| Chemical Formula: | Ca |
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| Weight: | Average: 40.078
Monoisotopic: 39.962591155 |
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| InChI Key: | BHPQYMZQTOCNFJ-UHFFFAOYSA-N |
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| InChI: | InChI=1S/Ca/q+2 |
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| CAS number: | 7440-70-2 |
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| IUPAC Name: | calcium(2+) ion |
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| Traditional IUPAC Name: | calcium(2+) ion |
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| SMILES: | [Ca++] |
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| Chemical Taxonomy |
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| Description | belongs to the class of inorganic compounds known as homogeneous alkaline earth metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkaline earth metal atom. |
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| Kingdom | Inorganic compounds |
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| Super Class | Homogeneous metal compounds |
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| Class | Homogeneous alkaline earth metal compounds |
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| Sub Class | Not Available |
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| Direct Parent | Homogeneous alkaline earth metal compounds |
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| Alternative Parents | Not Available |
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| Substituents | - Homogeneous alkaline earth metal
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| Molecular Framework | Not Available |
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| External Descriptors | |
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| Physical Properties |
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| State: | Solid |
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| Charge: | 2 |
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| Melting point: | 850 °C |
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| Experimental Properties: | |
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| Predicted Properties | |
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| Biological Properties |
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| Cellular Locations: | Cytoplasm |
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| Reactions: | |
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| SMPDB Pathways: | | glycerol metabolism | PW000914 |    | | glycerol metabolism II | PW000915 |    | | glycerol metabolism III (sn-glycero-3-phosphoethanolamine) | PW000916 |    | | glycerol metabolism IV (glycerophosphoglycerol) | PW000917 |    | | glycerol metabolism V (glycerophosphoserine) | PW000918 |    | | peptidoglycan biosynthesis I | PW000906 |    | | peptidoglycan biosynthesis I 2 | PW002062 |    | | threonine biosynthesis | PW000817 |    |
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| KEGG Pathways: | Not Available |
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| EcoCyc Pathways: | Not Available |
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| Concentrations |
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| | Concentration | Strain | Media | Growth Status | Growth System | Temperature | Details |
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| 0.09± 0.009 uM | K12 AN120 | Minimal media + 0.5% glycerol, Vitamin B1 (1.25 ug/mL); 0.1% casamino acids | Stationary Phase | Shake flask | 37 oC | PMID: 2442165 | | 6000± 0 uM | K-12 | Not Available | Not Available | Not Available | Not Available | 1. Cybercell Database: http://ccdb.wishartlab.com/CCDB/cgi-bin/STAT_NEW.cgi
2. Phillips R., Kondev, J., Theriot, J. (2008) “Physical Biology of the Cell” Garland Science, New York, NY. |
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| Spectra |
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| Spectra: | |
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| References |
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| References: | - Boonen S, Vanderschueren D, Haentjens P, Lips P: Calcium and vitamin D in the prevention and treatment of osteoporosis - a clinical update. J Intern Med. 2006 Jun;259(6):539-52. Pubmed: 16704554
- Dawson-Hughes B, Harris SS, Krall EA, Dallal GE: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6. Pubmed: 9278463
- Gangola, P., Rosen, B. P. (1987). "Maintenance of intracellular calcium in Escherichia coli." J Biol Chem 262:12570-12574. Pubmed: 2442165
- Gennari C: Calcium and vitamin D nutrition and bone disease of the elderly. Public Health Nutr. 2001 Apr;4(2B):547-59. Pubmed: 11683549
- Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, Anderson FH, Cooper C, Francis RM, Donaldson C, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA: Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005 May 7-13;365(9471):1621-8. Pubmed: 15885294
- Gross MD: Vitamin D and calcium in the prevention of prostate and colon cancer: new approaches for the identification of needs. J Nutr. 2005 Feb;135(2):326-31. Pubmed: 15671236
- Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O'Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D: Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006 Feb 16;354(7):669-83. Pubmed: 16481635
- Kirchhoff P, Geibel JP: Role of calcium and other trace elements in the gastrointestinal physiology. World J Gastroenterol. 2006 May 28;12(20):3229-36. Pubmed: 16718844
- Porthouse J, Cockayne S, King C, Saxon L, Steele E, Aspray T, Baverstock M, Birks Y, Dumville J, Francis R, Iglesias C, Puffer S, Sutcliffe A, Watt I, Torgerson DJ: Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ. 2005 Apr 30;330(7498):1003. Pubmed: 15860827
- Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003548. Pubmed: 16034903
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| Synthesis Reference: | Not Available |
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| Material Safety Data Sheet (MSDS) | Download (PDF) |
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| Links |
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| External Links: | |
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