KDO2-Lipid A (ECMDB21031) (M2MDB001447)

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA. Decanoyl, palmitoyl, palmitoleoyl, and (R)-3-hydroxymyristoyl-ACP are poor acyl donors. Functions optimally after laurate incorporation by htrB has taken place. Acylates (KDO)2-(lauroyl)-lipid IVA about 100 times faster than (KDO)2-lipid IVA. Displays a preference for myristoyl-ACP over lauroyl-ACP

Gene Name:

msbB

Uniprot ID:

P24205

Molecular weight:

37410

General function:

Involved in catalytic activity

Specific function:

Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (KDO) residue of a KDO(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol

Gene Name:

eptB

Uniprot ID:

P37661

Molecular weight:

63804

General function:

Involved in transferase activity, transferring pentosyl groups

Specific function:

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnT

Uniprot ID:

P76473

Molecular weight:

62542

Reactions

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

Heptose transfer to the lipopolysaccharide core. It transfers the innnermost heptose to [4'-P](3-deoxy-D-manno- octulosonic acid)2-IVA

Gene Name:

rfaC

Uniprot ID:

P24173

Molecular weight:

35544

General function:

Involved in lipopolysaccharide transport

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptG

Uniprot ID:

P0ADC6

Molecular weight:

39618

General function:

Involved in lipopolysaccharide-transporting ATPase acti

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptF

Uniprot ID:

P0AF98

Molecular weight:

40357

General function:

Involved in nucleotide binding

Specific function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Gene Name:

msbA

Uniprot ID:

P60752

Molecular weight:

64460

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system

Gene Name:

lptB

Uniprot ID:

P0A9V1

Molecular weight:

26800

General function:

Not Available

Specific function:

Not known; overproduction leads to camphor resistance and chromosome condensation

Gene Name:

crcA

Uniprot ID:

P37001

Molecular weight:

21770

General function:

Involved in lipopolysaccharide transmembrane transporter activity

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptC

Uniprot ID:

P0ADV9

Molecular weight:

21703

General function:

Involved in lipopolysaccharide binding

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain of LPS

Gene Name:

lptA

Uniprot ID:

P0ADV1

Molecular weight:

20127