PG(18:1(11Z)/18:1(11Z)) (ECMDB10618) (M2MDB000799)

General function:

Lipid transport and metabolism

Specific function:

2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate

Gene Name:

pldB

Uniprot ID:

P07000

Molecular weight:

38978

Reactions

General function:

Involved in phospholipase activity

Specific function:

Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins

Gene Name:

pldA

Uniprot ID:

P0A921

Molecular weight:

33163

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location

Gene Name:

pgpB

Uniprot ID:

P0A924

Molecular weight:

29021

Reactions

General function:

Involved in lipid biosynthetic process

Specific function:

Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge

Gene Name:

cfa

Uniprot ID:

P0A9H7

Molecular weight:

43909

Reactions

General function:

Involved in phosphatidylglycerophosphatase activity

Specific function:

One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate

Gene Name:

pgpA

Uniprot ID:

P18200

Molecular weight:

19418

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1

Gene Name:

aas

Uniprot ID:

P31119

Molecular weight:

80699

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Gene Name:

msbA

Uniprot ID:

P60752

Molecular weight:

64460

General function:

Not Available

Specific function:

Not known; overproduction leads to camphor resistance and chromosome condensation

Gene Name:

crcA

Uniprot ID:

P37001

Molecular weight:

21770

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Affects resistance to the gyrase inhibitor novobiocin

Gene Name:

cls

Uniprot ID:

P0A6H8

Molecular weight:

54822

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate. Catalyzes little, if any, cardiolipin synthesis in vivo, even when the expression level is very high

Gene Name:

ybhO

Uniprot ID:

P0AA84

Molecular weight:

47633

Reactions