2.02012-05-31 14:01:37 -06002015-07-14 14:32:03 -0600ECMDB03974M2MDB000548Oxalosuccinic acidOxalosuccinate is a substrate for cytoplasmic Isocitrate dehydrogenase and mitochondiral Isocitrate dehydrogenase (mitochondrial).Oxalo-succOxalosuccinateOxalosuccinic acidC6H6O7190.1076190.0113525461-oxopropane-1,2,3-tricarboxylic acidoxalosuccinate1948-82-9OC(=O)CC(C(O)=O)C(=O)C(O)=OInChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)UFSCUAXLTRFIDC-UHFFFAOYSA-NSolidCytoplasmPeriplasmlogp-0.55logs-1.41solubility7.47e+00 g/llogp-0.37pka_strongest_acidic2.38pka_strongest_basic-10iupac1-oxopropane-1,2,3-tricarboxylic acidaverage_mass190.1076mono_mass190.011352546smilesOC(=O)CC(C(O)=O)C(=O)C(O)=OformulaC6H6O7inchiInChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)inchikeyUFSCUAXLTRFIDC-UHFFFAOYSA-Npolar_surface_area128.97refractivity35.17polarizability14.95rotatable_bond_count5acceptor_count7donor_count3physiological_charge-3formal_charge0Glutathione metabolismThe biosynthesis of glutathione starts with the introduction of L-glutamic acid through either a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a
glutamate / aspartate ABC transporter. Once in the cytoplasm, L-glutamice acid reacts with L-cysteine through an ATP glutamate-cysteine ligase resulting in gamma-glutamylcysteine. This compound reacts which Glycine through an ATP driven glutathione synthetase thus catabolizing Glutathione.
This compound is metabolized through a spontaneous reaction with an oxidized glutaredoxin resulting in a reduced glutaredoxin and an oxidized glutathione. This compound is reduced by a NADPH glutathione reductase resulting in a glutathione.
PW000833ec00480MetabolicCitrate cycle (TCA cycle)ec00020Reductive carboxylate cycle (CO2 fixation)ec00720Microbial metabolism in diverse environmentsec01120Metabolic pathwayseco01100Specdb::CMs3033Specdb::CMs38681Specdb::NmrOneD288635Specdb::NmrOneD288636Specdb::NmrOneD288637Specdb::NmrOneD288638Specdb::NmrOneD288639Specdb::NmrOneD288640Specdb::NmrOneD288641Specdb::NmrOneD288642Specdb::NmrOneD288643Specdb::NmrOneD288644Specdb::NmrOneD288645Specdb::NmrOneD288646Specdb::NmrOneD288647Specdb::NmrOneD288648Specdb::NmrOneD288649Specdb::NmrOneD288650Specdb::NmrOneD288651Specdb::NmrOneD288652Specdb::NmrOneD288653Specdb::NmrOneD288654Specdb::MsMs28100Specdb::MsMs28101Specdb::MsMs28102Specdb::MsMs34658Specdb::MsMs34659Specdb::MsMs34660Specdb::MsMs3608797Specdb::MsMs3608798Specdb::MsMs3608799Specdb::MsMs3608800Specdb::MsMs3608801Specdb::MsMs3608802HMDB03974972C05379OXALO-SUCCINATEOxalosuccinic_acidKeseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590.21097882Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114.22080510Takeda, Isao; Iguchi, Takashi. Fermentative production of oxalosuccinic acid from hydrocarbons. Jpn. Tokkyo Koho (1972), 3 pp.Isocitrate dehydrogenase [NADP]P08200IDH_ECOLIicdhttp://ecmdb.ca/proteins/P08200.xmlOxalosuccinic acid <> alpha-Ketoglutarate + Carbon dioxideR00268Isocitric acid + NADP <> Oxalosuccinic acid + NADPH + Hydrogen ionR01899Oxalosuccinic acid + Hydrogen ion > Oxoglutaric acid + Carbon dioxideRXN-8642Isocitric acid + NADP > Oxalosuccinic acid + NADPH + Hydrogen ionR01899RXN-9951Isocitric acid + NADP + Oxalosuccinic acid <> alpha-Ketoglutarate + Carbon dioxide + NADPH + Hydrogen ionR00267