Triphosphate (ECMDB03379) (M2MDB000496)
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| Version | 2.0 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Creation Date | 2012-05-31 13:58:51 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Update Date | 2015-09-17 15:41:17 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary Accession Numbers |
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| Identification | |||||||||||||||||||||||||||||||||||||||||||||||||
| Name: | Triphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||
| Description | A triphosphate is a salt or ester containing three phosphate groups. It is the ionic form of triphosphoric acid, a condensed form of phosphoric acid. Triphosphate is an intermediate in the biosynthesis of Folate, the metabolism of purine, the metabolism of Porphyrin, the metabolism of Pyrimidine and the metabolism of Thiamine. The cleavage of the high energy triphosphate bonds in ATP (to ADP or AMP) is the central route of generating energy in cells. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | ||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms: |
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| Chemical Formula: | O10P3 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Weight: | Average: 252.9153 Monoisotopic: 252.870430756 | ||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Key: | UNXRWKVEANCORM-UHFFFAOYSA-I | ||||||||||||||||||||||||||||||||||||||||||||||||
| InChI: | InChI=1S/H5O10P3/c1-11(2,3)9-13(7,8)10-12(4,5)6/h(H,7,8)(H2,1,2,3)(H2,4,5,6)/p-5 | ||||||||||||||||||||||||||||||||||||||||||||||||
| CAS number: | 14127-68-5 | ||||||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name: | {[hydroxy(phosphonooxy)phosphoryl]oxy}phosphonic acid | ||||||||||||||||||||||||||||||||||||||||||||||||
| Traditional IUPAC Name: | tripolyphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||
| SMILES: | [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O | ||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Inorganic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Homogeneous non-metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
| Class | Non-metal oxoanionic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Non-metal phosphates | ||||||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Non-metal phosphates | ||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents | |||||||||||||||||||||||||||||||||||||||||||||||||
| Substituents |
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| Molecular Framework | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
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| Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
| State: | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||
| Charge: | -4 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Melting point: | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties: |
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| Predicted Properties |
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| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations: | Cytoplasm | ||||||||||||||||||||||||||||||||||||||||||||||||
| Reactions: | Water + Triphosphate > Hydrogen ion + Phosphate + Pyrophosphate Guanosine triphosphate + Water > Guanosine + Triphosphate dGTP + Water <> Deoxyguanosine + Triphosphate Adenosine triphosphate + Cob(I)alamin + Hydrogen ion <> Adenosylcobalamin + Triphosphate Adenosine triphosphate + Cobinamide + Hydrogen ion <> Adenosyl cobinamide + Triphosphate Adenosine triphosphate + Pyrophosphate <> ADP + Triphosphate Dihydroneopterin triphosphate + Water > Acetaldehyde + 6-Carboxy-5,6,7,8-tetrahydropterin + Hydrogen ion + Triphosphate Adenosine triphosphate + Cob(I)alamin <> Triphosphate + Adenosylcobalamin Dihydroneopterin triphosphate <> Dyspropterin + Triphosphate Cob(I)yrinate a,c diamide + Adenosine triphosphate <> Adenosyl cobyrinate a,c diamide + Triphosphate Adenosine triphosphate + Cobinamide <> Triphosphate + Adenosyl cobinamide Cob(I)yrinate a,c diamide + Adenosine triphosphate > Adenosyl cobinamide + Triphosphate Adenosine triphosphate + Cob(I)alamin > Adenosylcobalamin + Triphosphate Water + dGTP > Hydrogen ion + Triphosphate + Deoxyguanosine Adenosine triphosphate + Cob(I)yrinate a,c diamide > Triphosphate + Adenosylcob(III)yrinic acid a,c-diamide Adenosine triphosphate + Cobinamide > Triphosphate + Adenosyl cobinamide dGTP + Water > Deoxyguanosine + Triphosphate Dihydroneopterin triphosphate + Water > 6-Carboxy-5,6,7,8-tetrahydropterin + Acetaldehyde + Triphosphate Adenosine triphosphate + Cob(I)yrinate a,c diamide + Cobinamide <> Triphosphate + Adenosyl cobyrinate a,c diamide + Adenosyl cobinamide Triphosphate + Water <> Pyrophosphate + Phosphate Cobinamide + Adenosine triphosphate + Cobinamide > Adenosyl cobinamide + Triphosphate + Adenosyl cobinamide + Triphosphate Cobalamin + Adenosine triphosphate + vitamin B12 > coenzyme B12 + Triphosphate + Polyphosphate Adenosine triphosphate + Cobalamin + vitamin B12 > Triphosphate + Adenosylcobalamin + Triphosphate 7,8-dihydroneopterin 3'-triphosphate + Water > Acetaldehyde + Triphosphate +2 Hydrogen ion + 6-Carboxy-5,6,7,8-tetrahydropterin + Triphosphate dGTP + Water <> Deoxyguanosine + Triphosphate Dihydroneopterin triphosphate <> Dyspropterin + Triphosphate More...Dihydroneopterin triphosphate <> Dyspropterin + Triphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways: |
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| KEGG Pathways: | |||||||||||||||||||||||||||||||||||||||||||||||||
| EcoCyc Pathways: |
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| Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||
| Not Available | |||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra: | |||||||||||||||||||||||||||||||||||||||||||||||||
| References | |||||||||||||||||||||||||||||||||||||||||||||||||
| References: |
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| Synthesis Reference: | Tsuhako, Mitsutomo; Sueyoshi, Chiyoko; Miyajima, Tohru; Ohashi, Shigeru; Nariai, Hiroyuki; Motooka, Itaru. The reaction of cyclo-triphosphate with ethanolamines. Bulletin of the Chemical Society of Japan (1986), 59(10), 3091-5. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Material Safety Data Sheet (MSDS) | Download (PDF) | ||||||||||||||||||||||||||||||||||||||||||||||||
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Enzymes
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can also act in the reverse direction to form ATP in the presence of excess ADP. Can also use GTP instead of ATP; but the efficiency of GTP is 5% that of ATP
- Gene Name:
- ppk
- Uniprot ID:
- P0A7B1
- Molecular weight:
- 80431
Reactions
| ATP + (phosphate)(n) = ADP + (phosphate)(n+1). |
- General function:
- Involved in methionine adenosyltransferase activity
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth
- Gene Name:
- metK
- Uniprot ID:
- P0A817
- Molecular weight:
- 41951
Reactions
| ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase
- Gene Name:
- surE
- Uniprot ID:
- P0A840
- Molecular weight:
- 26900
Reactions
| A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
| A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. |
| (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
- Gene Name:
- btuR
- Uniprot ID:
- P0A9H5
- Molecular weight:
- 21999
Reactions
| ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. |
| ATP + cobinamide = triphosphate + adenosylcobinamide. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate
- Gene Name:
- ppx
- Uniprot ID:
- P0AFL6
- Molecular weight:
- 58136
Reactions
| (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs
- Gene Name:
- dgt
- Uniprot ID:
- P15723
- Molecular weight:
- 59382
Reactions
| dGTP + H(2)O = deoxyguanosine + triphosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Converts CNB12 to ADOB12
- Gene Name:
- eutT
- Uniprot ID:
- P65643
- Molecular weight:
- 30171
Reactions
| ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. |
| ATP + cobinamide = triphosphate + adenosylcobinamide. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP
- Gene Name:
- queD
- Uniprot ID:
- P65870
- Molecular weight:
- 13773
Reactions
| 7,8-dihydroneopterin 3'-triphosphate + H(2)O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate. |