Nitrite (ECMDB02786) (M2MDB000465)

General function:

Involved in oxidation-reduction process

Specific function:

Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H

Gene Name:

nirB

Uniprot ID:

P08201

Molecular weight:

93121

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The alpha chain is the actual site of nitrate reduction

Gene Name:

narG

Uniprot ID:

P09152

Molecular weight:

140489

Reactions

General function:

Involved in nitrite reductase [NAD(P)H] activity

Specific function:

Required for activity of the reductase

Gene Name:

nirD

Uniprot ID:

P0A9I8

Molecular weight:

12284

Reactions

General function:

Involved in nitrogen compound metabolic process

Specific function:

Plays a role in nitrite reduction

Gene Name:

nrfA

Uniprot ID:

P0ABK9

Molecular weight:

53703

Reactions

General function:

Involved in nitrate reductase activity

Specific function:

This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit

Gene Name:

narV

Uniprot ID:

P0AF32

Molecular weight:

26018

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit

Gene Name:

narH

Uniprot ID:

P11349

Molecular weight:

58066

Reactions

General function:

Involved in nitrate reductase activity

Specific function:

The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit

Gene Name:

narI

Uniprot ID:

P11350

Molecular weight:

25497

Reactions

General function:

Involved in unfolded protein binding

Specific function:

Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 2

Gene Name:

narW

Uniprot ID:

P19317

Molecular weight:

26160

General function:

Involved in iron-sulfur cluster binding

Specific function:

This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit

Gene Name:

narY

Uniprot ID:

P19318

Molecular weight:

58557

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The alpha chain is the actual site of nitrate reduction

Gene Name:

narZ

Uniprot ID:

P19319

Molecular weight:

140226

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein napC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism

Gene Name:

napA

Uniprot ID:

P33937

Molecular weight:

93041

Reactions

General function:

Involved in electron carrier activity

Specific function:

Involved in electron transfer (Probable)

Gene Name:

napG

Uniprot ID:

P0AAL3

Molecular weight:

24924

General function:

Involved in electron carrier activity

Specific function:

Involved in electron transfer

Gene Name:

napH

Uniprot ID:

P33934

Molecular weight:

31873

General function:

Inorganic ion transport and metabolism

Specific function:

Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes

Gene Name:

nrfD

Uniprot ID:

P32709

Molecular weight:

35042

General function:

Involved in electron carrier activity

Specific function:

Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes

Gene Name:

nrfC

Uniprot ID:

P0AAK7

Molecular weight:

24567

General function:

Involved in heme binding

Specific function:

Plays a role in nitrite reduction

Gene Name:

nrfB

Uniprot ID:

P0ABL1

Molecular weight:

20714

General function:

Energy production and conversion

Specific function:

Small subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme napC protein, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism

Gene Name:

napB

Uniprot ID:

P0ABL3

Molecular weight:

16297

General function:

Involved in heme binding

Specific function:

Mediates electron flow from quinones to the napAB complex

Gene Name:

napC

Uniprot ID:

P0ABL5

Molecular weight:

23100

General function:

Involved in unfolded protein binding

Specific function:

Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1. Required for the insertion of the molybdenum into the apo-NarG subunit, maybe by keeping NarG in an appropriate competent-open conformation for the molybdenum cofactor insertion to occur. NarJ maintains the apoNarGH complex in a soluble state. Upon insertion of the molybdenum cofactor, NarJ seems to dissociate from the activated soluble NarGH complex, before its association with the NarI subunit on the membrane

Gene Name:

narJ

Uniprot ID:

P0AF26

Molecular weight:

26449

General function:

Not Available

Specific function:

Not Available

Gene Name:

yeaW

Uniprot ID:

P0ABR7

Molecular weight:

Not Available

General function:

Not Available

Specific function:

Not Available

Gene Name:

nrfE

Uniprot ID:

P32710

Molecular weight:

Not Available