Tetrahydrofolic acid (ECMDB01846) (M2MDB000424)

General function:

Involved in hydroxymethyl-, formyl- and related transferase activity

Specific function:

10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide

Gene Name:

purN

Uniprot ID:

P08179

Molecular weight:

23238

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Uniprot ID:

P08192

Molecular weight:

45405

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Uniprot ID:

P0A825

Molecular weight:

45316

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Gene Name:

lpdA

Uniprot ID:

P0A9P0

Molecular weight:

50688

Reactions

General function:

Involved in dihydrofolate reductase activity

Specific function:

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis

Gene Name:

folA

Uniprot ID:

P0ABQ4

Molecular weight:

17999

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of dihydrofolate to tetrahydrofolate

Gene Name:

folM

Uniprot ID:

P0AFS3

Molecular weight:

26348

Reactions

General function:

Involved in methionine synthase activity

Specific function:

Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate

Gene Name:

metH

Uniprot ID:

P13009

Molecular weight:

135996

Reactions

General function:

Involved in IMP cyclohydrolase activity

Specific function:

10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Gene Name:

purH

Uniprot ID:

P15639

Molecular weight:

57329

Reactions

General function:

Involved in methionyl-tRNA formyltransferase activity

Specific function:

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP

Gene Name:

fmt

Uniprot ID:

P23882

Molecular weight:

34168

Reactions

General function:

Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity

Specific function:

Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation

Gene Name:

metE

Uniprot ID:

P25665

Molecular weight:

84673

Reactions

General function:

Involved in aminomethyltransferase activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine

Gene Name:

gcvT

Uniprot ID:

P27248

Molecular weight:

40146

Reactions

General function:

Involved in 3-methyl-2-oxobutanoate hydroxymethyltransferase activity

Specific function:

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

Gene Name:

panB

Uniprot ID:

P31057

Molecular weight:

28237

Reactions

General function:

Involved in glycine dehydrogenase (decarboxylating) activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

Gene Name:

gcvP

Uniprot ID:

P33195

Molecular weight:

104376

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP

Gene Name:

purT

Uniprot ID:

P33221

Molecular weight:

42433

Reactions

General function:

Involved in amino acid binding

Specific function:

Produces formate from formyl-tetrahydrofolate. Provides the major source of formate for the purT-dependent synthesis of 5'-phosphoribosyl-N-formylglycinamide (FGAR) during aerobic growth. Has a role in regulating the one-carbon pool

Gene Name:

purU

Uniprot ID:

P37051

Molecular weight:

31934

Reactions

General function:

Involved in hydroxymethyl-, formyl- and related transferase activity

Specific function:

Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnA

Uniprot ID:

P77398

Molecular weight:

74288

Reactions

General function:

Amino acid transport and metabolism

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein

Gene Name:

gcvH

Uniprot ID:

P0A6T9

Molecular weight:

13811