2.0 2012-05-31 13:52:23 -0600 2015-09-13 12:56:11 -0600 ECMDB01426 M2MDB000382 Formaldehyde Formaldehyde is a highly reactive aldehyde gas. It is the simplest aldehyde. Its chemical formula is H2CO. Although formaldehyde is a gas at room temperature, it is readily soluble in water, and it is most commonly sold as a 37% solution in water called by trade names such as formalin or formol. In water, formaldehyde polymerizes, and formalin actually contains very little formaldehyde in the form of H2CO monomer. Formaldehyde exhibits most of the general chemical properties of the aldehydes, except that is generally more reactive than other aldehydes. Formaldehyde is a potent electrophile. It can participate in electrophilic aromatic substitution reactions with aromatic compounds and can undergo electrophilic addition reactions with alkenes. In E. coli, formaldehyde is formed by the breakdown of N-methyltryptophan and FMNH by their corresponding oxidases. Aldeide formica Chlodithan Chlodithane Fannoform Formaldehyde Formalin Formalina Formaline Formalith Formic aldehyde Formol Methaldehyde Methanal Methylene glycol Methylene oxide Oxomethylene Paraform CH2O 30.026 30.010564686 formaldehyde formaldehyde 50-00-0 C=O InChI=1S/CH2O/c1-2/h1H2 WSFSSNUMVMOOMR-UHFFFAOYSA-N Liquid Cytosol Extra-organism Periplasm logp -0.68 ALOGPS logs 0.82 ALOGPS solubility 1.98e+02 g/l ALOGPS melting_point -92 oC logp -0.47 ChemAxon pka_strongest_basic -8.1 ChemAxon iupac formaldehyde ChemAxon average_mass 30.026 ChemAxon mono_mass 30.010564686 ChemAxon smiles C=O ChemAxon formula CH2O ChemAxon inchi InChI=1S/CH2O/c1-2/h1H2 ChemAxon inchikey WSFSSNUMVMOOMR-UHFFFAOYSA-N ChemAxon polar_surface_area 17.07 ChemAxon refractivity 6.31 ChemAxon polarizability 2.58 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Methane metabolism ec00680 Microbial metabolism in diverse environments ec01120 Chloroalkane and chloroalkene degradation ec00625 formaldehyde oxidation II (glutathione-dependent) PWY-1801 Specdb::CMs 3285 Specdb::CMs 165347 Specdb::EiMs 1163 Specdb::NmrOneD 2400 Specdb::NmrOneD 4841 Specdb::NmrOneD 4842 Specdb::NmrOneD 147690 Specdb::NmrOneD 147691 Specdb::NmrOneD 147692 Specdb::NmrOneD 147693 Specdb::NmrOneD 147694 Specdb::NmrOneD 147695 Specdb::NmrOneD 147696 Specdb::NmrOneD 147697 Specdb::NmrOneD 147698 Specdb::NmrOneD 147699 Specdb::MsMs 10430 Specdb::MsMs 10431 Specdb::MsMs 10432 Specdb::MsMs 17102 Specdb::MsMs 17103 Specdb::MsMs 17104 Specdb::MsMs 3039089 Specdb::MsMs 3039090 Specdb::MsMs 3039091 Specdb::MsMs 3101888 Specdb::MsMs 3101889 Specdb::MsMs 3101890 Specdb::NmrTwoD 1070 HMDB01426 712 692 C00067 16842 FORMALDEHYDE FOR Formaldehyde Keseler, I. 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Arch Pathol Lab Med. 1994 Jun;118(6):633-9. 8204010 http://hmdb.ca/system/metabolites/msds/000/001/288/original/HMDB01426.pdf?1358461418 Catalase-peroxidase P13029 KATG_ECOLI katG http://ecmdb.ca/proteins/P13029.xml Catalase HPII P21179 CATE_ECOLI katE http://ecmdb.ca/proteins/P21179.xml Primary amine oxidase P46883 AMO_ECOLI tynA http://ecmdb.ca/proteins/P46883.xml FMN reductase P80644 SSUE_ECOLI ssuE http://ecmdb.ca/proteins/P80644.xml Alkanesulfonate monooxygenase P80645 SSUD_ECOLI ssuD http://ecmdb.ca/proteins/P80645.xml N-methyl-L-tryptophan oxidase P40874 MTOX_ECOLI solA http://ecmdb.ca/proteins/P40874.xml Alpha-ketoglutarate-dependent dioxygenase AlkB P05050 alkB http://ecmdb.ca/proteins/P05050.xml Outer membrane protein N P77747 OMPN_ECOLI ompN http://ecmdb.ca/proteins/P77747.xml Outer membrane pore protein E P02932 PHOE_ECOLI phoE http://ecmdb.ca/proteins/P02932.xml Outer membrane protein F P02931 OMPF_ECOLI ompF http://ecmdb.ca/proteins/P02931.xml Outer membrane protein C P06996 OMPC_ECOLI ompC http://ecmdb.ca/proteins/P06996.xml FMNH + Methanesulfonate + Oxygen > Formaldehyde + Flavin Mononucleotide + Hydrogen ion + Water + Sulfite Water + Oxygen + Sarcosine > Formaldehyde + Glycine + Hydrogen peroxide N-Methyltryptophan + Water + Oxygen > Formaldehyde + Hydrogen peroxide + L-Tryptophan RXN0-301 Formaldehyde + Glutathione <> S-(Hydroxymethyl)glutathione RXN-2961 Methanol + Hydrogen peroxide <> Formaldehyde +2 Water R00602 Methylamine + Oxygen + Water <> Formaldehyde + Ammonia + Hydrogen peroxide R06154 Formaldehyde + Tetrahydrofolic acid > 5,10-Methylene-THF + Water RXN-2881 a methylated nucleobase within DNA + Oxygen + Oxoglutaric acid Hydrogen ion + a nucleobase within DNA + Carbon dioxide + Formaldehyde + Succinic acid RXN-12353 S-(Hydroxymethyl)glutathione <> Formaldehyde + Glutathione RXN-2961 N1-Methyladenine + Oxygen + Oxoglutaric acid > Hydrogen ion + Adenine + Carbon dioxide + Formaldehyde + Succinic acid RXN0-984 N3-Methylcytosine + Oxygen + Oxoglutaric acid > Hydrogen ion + Cytosine + Carbon dioxide + Formaldehyde + Succinic acid RXN0-985 DNA-base-CH(3) + Oxoglutaric acid + Oxygen > DNA-base + Formaldehyde + Succinic acid + Carbon dioxide N-methyl-L-tryptophan + Water + Oxygen > L-Tryptophan + Formaldehyde + Hydrogen peroxide