2.02012-05-31 13:45:16 -06002015-06-03 15:53:44 -0600ECMDB01106M2MDB0002553-Aminopropionaldehyde3-Aminopropanal is a reactive aldehyde.3-Aminopropanal3-Aminopropionaldehydeb-Aminopropion aldehydeBeta-Aminopropion aldehydeβ-Aminopropion aldehydeC3H7NO73.093873.0527638513-aminopropanal3-aminopropanal352-92-1NCCC=OInChI=1S/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2PCXDJQZLDDHMGX-UHFFFAOYSA-NSolidCytoplasmPeriplasmlogp-1.23logs0.78solubility4.44e+02 g/llogp-1.1pka_strongest_acidic14.19pka_strongest_basic9.68iupac3-aminopropanalaverage_mass73.0938mono_mass73.052763851smilesNCCC=OformulaC3H7NOinchiInChI=1S/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2inchikeyPCXDJQZLDDHMGX-UHFFFAOYSA-Npolar_surface_area43.09refractivity19.78polarizability7.71rotatable_bond_count2acceptor_count2donor_count1physiological_charge1formal_charge0beta-Alanine metabolismThe Beta-Alanine Metabolism starts with a product of Aspartate metabolism. Aspartate is decarboxylated by aspartate 1-decarboxylase, releasing carbon dioxide and Beta-alanine. Beta alanine is then metabolized through a pantothenate synthetase resulting in Pantothenic acid undergoes phosphorylation through a ATP driven pantothenate kinase, resulting in D-4-phosphopantothenate.
Pantothenate (vitamin B5) is the universal precursor for the synthesis of the 4'-phosphopantetheine moiety of coenzyme A and acyl carrier protein. Only plants and microorganismscan synthesize pantothenate de novo - animals require a dietary supplement. The enzymes of this pathway are therefore considered to be antimicrobial drug targets.PW000896ec00410MetabolicSpecdb::CMs3363Specdb::CMs146299Specdb::NmrOneD8622Specdb::NmrOneD8623Specdb::NmrOneD8624Specdb::NmrOneD8625Specdb::NmrOneD8626Specdb::NmrOneD8627Specdb::NmrOneD8628Specdb::NmrOneD8629Specdb::NmrOneD8630Specdb::NmrOneD8631Specdb::NmrOneD8632Specdb::NmrOneD8633Specdb::NmrOneD8634Specdb::NmrOneD8635Specdb::NmrOneD8636Specdb::NmrOneD8637Specdb::NmrOneD8638Specdb::NmrOneD8639Specdb::NmrOneD8640Specdb::NmrOneD8641Specdb::MsMs20177Specdb::MsMs20178Specdb::MsMs20179Specdb::MsMs21728Specdb::MsMs21729Specdb::MsMs21730Specdb::MsMs2743201Specdb::MsMs2743202Specdb::MsMs2743203Specdb::MsMs2935517Specdb::MsMs2935518Specdb::MsMs2935519HMDB011067574C05665180903-AMINO-PROPANALKanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114.22080510Ivanova S, Batliwalla F, Mocco J, Kiss S, Huang J, Mack W, Coon A, Eaton JW, Al-Abed Y, Gregersen PK, Shohami E, Connolly ES Jr, Tracey KJ: Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5579-84. Epub 2002 Apr 9.11943872Yu Z, Li W, Hillman J, Brunk UT: Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal. Brain Res. 2004 Aug 6;1016(2):163-9.15246852Bott, Kaspar. Amidomethylation of trichloroethylene and acetylene: syntheses of N-protected a-chloro-b-alanines and b-aminopropanals. Journal of the Chemical Society [Section] D: Chemical Communications (1969), (22), 1304.Primary amine oxidaseP46883AMO_ECOLItynAhttp://ecmdb.ca/proteins/P46883.xml1,3-Diaminopropane + Oxygen + Water <> 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxideR03139