ECMDB: Succinyl-CoA (ECMDB01022) (M2MDB000228)

Identification Taxonomy Physical Properties Biological Properties Spectra Concentrations Links References Enzymes (14)XML

Proteins (4354)

Record Information

Version

2.0

Creation Date

2012-05-31 13:03:35 -0600

Update Date

2015-09-17 15:41:07 -0600

Secondary Accession Numbers

ECMDB01022

Identification

Name:

Succinyl-CoA

Description

Succinyl-CoA is a combination of succinic acid and coenzyme A. It is an important intermediate in the citric acid cycle, where it is synthesized from alpha-Ketoglutarate by alpha-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added. It is also synthesized from propionyl CoA, the odd-numbered fatty acid, which cannot undergo beta-oxidation. Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerized to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle.

Structure

MOL SDF PDB SMILES InChI

Synonyms:

CoA S-(hydrogen succinate)
CoA S-(Hydrogen succinic acid)
CoA S-succinate
CoA S-succinic acid
Coenzyme A S-(hydrogen succinate)
coenzyme A S-(Hydrogen succinic acid)
Coenzyme A S-succinate
Coenzyme A S-succinic acid
S-(Hydrogen butanedioate
S-(Hydrogen butanedioate) CoA
S-(Hydrogen butanedioate) Coenzyme A
S-(Hydrogen butanedioic acid
S-(Hydrogen butanedioic acid) CoA
S-(Hydrogen butanedioic acid) coenzyme A
S-Succinoylcoenzyme A
Suc-co-A
Suc-coa
Succ-S-CoA
Succ-S-coenzyme-A
Succ-CoA
Succ-Coenzyme A
Succ-coenzyme-A
Succ-S-CoA
Succ-S-Coenzyme A
Succ-S-coenzyme-A
Succino-1-yl-coenzyme a
Succinyl CoA
Succinyl coenzyme A
Succinyl-S-CoA
Succinyl-coenzyme A
Succinyl-S-CoA
Succinyl-S-Coenzyme A
Succinyl-S-coenzyme-A
Succinylcoenzyme A
Succinylcoenzyme-A
SucCoA

Chemical Formula:

C₂₅H₄₀N₇O₁₉P₃S

Weight:

Average: 867.607
Monoisotopic: 867.131252359

InChI Key:

VNOYUJKHFWYWIR-FZEDXVDRSA-N

InChI:

InChI=1S/C25H40N7O19P3S/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/t13-,18-,19-,20?,24-/m1/s1

CAS number:

604-98-8

IUPAC Name:

4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acid

Traditional IUPAC Name:

succinyl-coa

SMILES:

CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O

Chemical Taxonomy

Description

belongs to the class of organic compounds known as acyl coas. These are organic compounds containing a coenzyme A substructure linked to an acyl chain.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acyl thioesters

Direct Parent

Acyl CoAs

Alternative Parents

Substituents

Coenzyme a or derivatives
Purine ribonucleoside diphosphate
Purine ribonucleoside bisphosphate
Purine ribonucleoside 3',5'-bisphosphate
Ribonucleoside 3'-phosphate
Pentose-5-phosphate
Pentose phosphate
Glycosyl compound
N-glycosyl compound
Organic pyrophosphate
Pentose monosaccharide
6-aminopurine
Monosaccharide phosphate
Purine
Imidazopyrimidine
Hydroxy fatty acid
Thia fatty acid
Aminopyrimidine
Monoalkyl phosphate
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Imidolactam
Phosphoric acid ester
Alkyl phosphate
Pyrimidine
Tetrahydrofuran
Azole
Imidazole
Heteroaromatic compound
Thiocarboxylic acid ester
Secondary alcohol
Carbothioic s-ester
Amino acid or derivatives
Amino acid
Thiocarboxylic acid or derivatives
Propargyl-type 1,3-dipolar organic compound
Organic 1,3-dipolar compound
Sulfenyl compound
Carboximidic acid
Carboximidic acid derivative
Carboxylic acid derivative
Carboxylic acid
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Oxacycle
Azacycle
Organopnictogen compound
Organic oxide
Organic oxygen compound
Hydrocarbon derivative
Organosulfur compound
Organooxygen compound
Primary amine
Organic nitrogen compound
Alcohol
Amine
Carbonyl group
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

omega-carboxyacyl-CoA (CHEBI:15380 )

Physical Properties

State:

Solid

Charge:

-5

Melting point:

Not Available

Experimental Properties:

Property	Value	Source

Predicted Properties

Property	Value	Source
Water Solubility	3.84 g/L	ALOGPS
logP	-0.61	ALOGPS
logP	-6.1	ChemAxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	0.82	ChemAxon
pKa (Strongest Basic)	4.24	ChemAxon
Physiological Charge	-5	ChemAxon
Hydrogen Acceptor Count	19	ChemAxon
Hydrogen Donor Count	10	ChemAxon
Polar Surface Area	400.93 Å²	ChemAxon
Rotatable Bond Count	23	ChemAxon
Refractivity	183.1 m³·mol⁻¹	ChemAxon
Polarizability	77.46 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	0	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Biological Properties

Cellular Locations:

Cytoplasm

Reactions:

alpha-Ketoglutarate + Coenzyme A + NAD > Carbon dioxide + NADH + Succinyl-CoA
Adenosine triphosphate + Coenzyme A + Succinic acid <> ADP + Phosphate + Succinyl-CoA
Water + Succinyl-CoA + Tetrahydrodipicolinate <> Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
Coenzyme A + 3-Oxoadipyl-CoA <> Acetyl-CoA + Succinyl-CoA
L-Arginine + Succinyl-CoA <> Coenzyme A + Hydrogen ion + N2-Succinyl-L-arginine
Succinyl-CoA > (S)-Methylmalonyl-CoA
Propionyl-CoA + Succinic acid > Propionic acid + Succinyl-CoA
L-Homoserine + Succinyl-CoA <> Coenzyme A + O-Succinyl-L-homoserine
Succinyl-CoA + Acetyl-CoA <> Coenzyme A + 3-Oxoadipyl-CoA
Succinyl-CoA + L-Arginine <> Coenzyme A + N2-Succinyl-L-arginine
(R)-Methylmalonyl-CoA <> Succinyl-CoA
Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine + Enzyme N6-(dihydrolipoyl)lysine <> Coenzyme A + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
Oxoglutaric acid + Coenzyme A + NAD > Succinyl-CoA + Carbon dioxide + NADH
L-Arginine + Succinyl-CoA > Hydrogen ion + N2-Succinyl-L-arginine + Coenzyme A
L-Homoserine + Succinyl-CoA > O-Succinyl-L-homoserine + Coenzyme A
R-Methylmalonyl-CoA <> Succinyl-CoA
Succinyl-CoA + Acetyl-CoA < 3-Oxoadipyl-CoA + Coenzyme A
Propionyl-CoA + Succinic acid <> Propionic acid + Succinyl-CoA
Succinyl-CoA + L-Arginine > CoA + N2-Succinyl-L-arginine
Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + Water > CoA + N-Succinyl-2-amino-6-ketopimelate
Succinyl-CoA + L-Homoserine > CoA + O-Succinyl-L-homoserine
Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine > CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine
Succinyl-CoA + Acetyl-CoA > CoA + 3-Oxoadipyl-CoA
R-Methylmalonyl-CoA > Succinyl-CoA
Adenosine triphosphate + Succinic acid + CoA > ADP + Inorganic phosphate + Succinyl-CoA

Acetoacetyl-CoA + Coenzyme A + Acetoacetyl-CoA > Acetyl-CoA + Succinyl-CoA + Succinyl-CoA
(S)-2,3,4,5-tetrahydrodipicolinate + Succinyl-CoA + Water + Succinyl-CoA > Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
Oxoglutaric acid + NAD + Coenzyme A > Succinyl-CoA + NADH + Hydrogen ion + Carbon dioxide + Succinyl-CoA
Succinyl-CoA + Phosphate + Guanosine diphosphate + Succinyl-CoA <> Succinic acid + Coenzyme A + Guanosine triphosphate
Oxoglutaric acid + NAD + Coenzyme A > NADH + Carbon dioxide + Succinyl-CoA + Succinyl-CoA
Succinyl-CoA + Adenosine diphosphate + Phosphate + Succinyl-CoA + ADP > Adenosine triphosphate + Coenzyme A + Succinic acid
L-Arginine + Succinyl-CoA + Succinyl-CoA > Coenzyme A + Hydrogen ion + N2-succinyl-L-arginine + N2-succinyl-L-arginine
L-Homoserine + Succinyl-CoA + L-Homoserine + Succinyl-CoA > Coenzyme A + O-Succinyl-L-homoserine
Succinic acid + Propionyl-CoA + Propionyl-CoA > Propionic acid + Succinyl-CoA + Succinyl-CoA
Succinyl-CoA + Succinyl-CoA > Methylmalonyl-CoA
Succinyl-CoA + Dihydrolipoamide + Succinyl-CoA + Dihydrolipoamide > Coenzyme A + (S)-Succinyldihydrolipoamide
3-Oxoadipyl-CoA + Coenzyme A > Acetyl-CoA + Succinyl-CoA
Succinyl-CoA <> R-Methylmalonyl-CoA
a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine + Succinyl-CoA > a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + Coenzyme A
L-Arginine + Succinyl-CoA <> Coenzyme A + Hydrogen ion + N2-Succinyl-L-arginine
Adenosine triphosphate + Coenzyme A + Succinic acid <> ADP + Phosphate + Succinyl-CoA
Water + Succinyl-CoA + Tetrahydrodipicolinate <> Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
L-Arginine + Succinyl-CoA <> Coenzyme A + Hydrogen ion + N2-Succinyl-L-arginine
Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <> Coenzyme A + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
Adenosine triphosphate + Coenzyme A + Succinic acid <> ADP + Phosphate + Succinyl-CoA

More...

SMPDB Pathways:

2-oxoglutarate decarboxylation to succinyl-CoA	PW002108
Conversion of Succinate to Propanoate	PW002058
Lysine biosynthesis	PW000771
Phenylalanine metabolism	PW000921
Phenylethylamine metabolism	PW002027
Propanoate metabolism	PW000940
Sulfur metabolism	PW000922
TCA cycle	PW000779
TCA cycle (ubiquinol-0)	PW002023
TCA cycle (ubiquinol-10)	PW001010
TCA cycle (ubiquinol-2)	PW001002
TCA cycle (ubiquinol-3)	PW001003
TCA cycle (ubiquinol-4)	PW001004
TCA cycle (ubiquinol-5)	PW001005
TCA cycle (ubiquinol-6)	PW001006
TCA cycle (ubiquinol-7)	PW001007
TCA cycle (ubiquinol-8)	PW001008
TCA cycle (ubiquinol-9)	PW001009
arginine metabolism	PW000790
fatty acid oxidation (Butanoate)	PW001017
glycolysis and pyruvate dehydrogenase	PW000785
methionine biosynthesis	PW000814
propanoyl CoA degradation	PW002057

KEGG Pathways:

Arginine and proline metabolism ec00330
Benzoate degradation via hydroxylation ec00362
C5-Branched dibasic acid metabolism ec00660
Citrate cycle (TCA cycle) ec00020
Cysteine and methionine metabolism ec00270
Glyoxylate and dicarboxylate metabolism ec00630
Lysine biosynthesis ec00300
Lysine degradation ec00310
Metabolic pathways eco01100
Microbial metabolism in diverse environments ec01120
Naphthalene degradation ec00626
Phenylalanine metabolism ec00360
Propanoate metabolism ec00640
Reductive carboxylate cycle (CO2 fixation) ec00720
Sulfur metabolism ec00920
Toluene degradation ec00623
Valine, leucine and isoleucine degradation ec00280

EcoCyc Pathways:

2-ketoglutarate dehydrogenase complex PWY-5084
TCA cycle I (prokaryotic) TCA
arginine degradation II (AST pathway) AST-PWY
conversion of succinate to propionate PWY0-43
lysine biosynthesis I DAPLYSINESYN-PWY
methionine biosynthesis I HOMOSER-METSYN-PWY
methylmalonyl pathway PROPIONMET-PWY
phenylacetate degradation I (aerobic) PWY0-321

Concentrations

Concentration	Strain	Media	Growth Status	Growth System	Temperature	Details
233± 0 uM	K12 NCM3722	Gutnick minimal complete medium (4.7 g/L KH2PO4; 13.5 g/L K2HPO4; 1 g/L K2SO4; 0.1 g/L MgSO4-7H2O; 10 mM NH4Cl) with 4 g/L glucose	Mid-Log Phase	Shake flask and filter culture	37 oC	PMID: 19561621
1440± 0 uM	K12 NCM3722	Gutnick minimal complete medium (4.7 g/L KH2PO4; 13.5 g/L K2HPO4; 1 g/L K2SO4; 0.1 g/L MgSO4-7H2O; 10 mM NH4Cl) with 4 g/L glycerol	Mid-Log Phase	Shake flask and filter culture	37 oC	PMID: 19561621
390± 0 uM	K12 NCM3722	Gutnick minimal complete medium (4.7 g/L KH2PO4; 13.5 g/L K2HPO4; 1 g/L K2SO4; 0.1 g/L MgSO4-7H2O; 10 mM NH4Cl) with 4 g/L acetate	Mid-Log Phase	Shake flask and filter culture	37 oC	PMID: 19561621

Find out more about how we convert literature concentrations.

Spectra

Spectra:

Spectrum Type	Description	Splash Key
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-1912000130-5d37f85b68294f1bcd7b	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0913000000-5f3ce9a55c6b75d06990	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-2911000000-d4965f3bcf572b49e153	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-017j-8921150580-9a135870fabc65b05d2e	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-003s-4910010010-1b02ce20692d0ded522e	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-057i-6900100000-44f1bfaeb10b1463a0bd	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-014i-0000000090-bb5a570be808ea8a3dd8	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00kg-9100001430-6a56696bfa6b84fc9826	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-016r-8102403910-3e8c6747e8bdbda6db09	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014r-0300000090-ce1ea17de736a3128d73	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0901000020-307a08ff7ab07e0b6165	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-1119000000-859564ca28518883d359	View in MoNA
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer

References

References:

Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. (2009). "Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli." Nat Chem Biol 5:593-599. Pubmed: 19561621
Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. Pubmed: 17765195
Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948. Pubmed: 18331064

Synthesis Reference:

Wollemann, M. Mechanism of the succinyl-coenzyme A synthesis in brain extracts. Acta Physiologica Academiae Scientiarum Hungaricae (1959), 16 153-4.

Material Safety Data Sheet (MSDS)

Not Available

Links

External Links:

Resource	Link
CHEBI ID	15380
HMDB ID	HMDB01022
Pubchem Compound ID	439161
Kegg ID	C00091
ChemSpider ID	388307
Wikipedia	Succinyl-CoA
BioCyc ID	SUC-COA
EcoCyc ID	SUC-COA
Ligand Expo	SCA

Enzymes

Protein Details

1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

General function:: Involved in transferase activity, transferring acyl groups
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
Gene Name:: aceF
Uniprot ID:: P06959
Molecular weight:: 66096

Reactions

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

Protein Details

2. Homoserine O-succinyltransferase

General function:: Involved in transferase activity, transferring acyl groups
Specific function:: Succinyl-CoA + L-homoserine = CoA + O- succinyl-L-homoserine
Gene Name:: metA
Uniprot ID:: P07623
Molecular weight:: 35727

Reactions

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine.

Protein Details

3. Succinyl-CoA ligase [ADP-forming] subunit beta

General function:: Involved in ATP binding
Specific function:: ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Gene Name:: sucC
Uniprot ID:: P0A836
Molecular weight:: 41392

Reactions

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Protein Details

4. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

General function:: Involved in 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
Specific function:: Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine- 2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6- oxoheptanedioate
Gene Name:: dapD
Uniprot ID:: P0A9D8
Molecular weight:: 29892

Reactions

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.

Protein Details

5. Dihydrolipoyl dehydrogenase

General function:: Involved in oxidoreductase activity
Specific function:: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
Gene Name:: lpdA
Uniprot ID:: P0A9P0
Molecular weight:: 50688

Reactions

Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.

Protein Details

6. Arginine N-succinyltransferase

General function:: Involved in arginine N-succinyltransferase activity
Specific function:: Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine
Gene Name:: astA
Uniprot ID:: P0AE37
Molecular weight:: 38456

Reactions

Succinyl-CoA + L-arginine = CoA + N(2)-succinyl-L-arginine.

Protein Details

7. 2-oxoglutarate dehydrogenase E1 component

General function:: Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity
Specific function:: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
Gene Name:: sucA
Uniprot ID:: P0AFG3
Molecular weight:: 105061

Reactions

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).

Protein Details

8. Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex

General function:: Involved in transferase activity, transferring acyl groups
Specific function:: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
Gene Name:: sucB
Uniprot ID:: P0AFG6
Molecular weight:: 44011

Reactions

Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine.

Protein Details

9. Succinyl-CoA ligase [ADP-forming] subunit alpha

General function:: Involved in catalytic activity
Specific function:: ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Gene Name:: sucD
Uniprot ID:: P0AGE9
Molecular weight:: 29777

Reactions

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Protein Details

10. Beta-ketoadipyl-CoA thiolase

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA
Gene Name:: paaJ
Uniprot ID:: P0C7L2
Molecular weight:: 42276

Reactions

Succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA.
2,3-dehydroadipyl-CoA + acetyl-CoA = CoA + 3-oxo-5,6-dehydrosuberyl-CoA.

Protein Details

11. 3-ketoacyl-CoA thiolase

General function:: Involved in acetyl-CoA C-acyltransferase activity
Specific function:: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids
Gene Name:: fadA
Uniprot ID:: P21151
Molecular weight:: 40876

Reactions

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Protein Details

12. Protein sbm

General function:: Involved in isomerase activity
Specific function:: Specific function unknown
Gene Name:: sbm
Uniprot ID:: P27253
Molecular weight:: 77871

Reactions

(R)-methylmalonyl-CoA = succinyl-CoA.

Protein Details

13. 3-ketoacyl-CoA thiolase_

General function:: Involved in transferase activity
Specific function:: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long- chain fatty acids
Gene Name:: fadI
Uniprot ID:: P76503
Molecular weight:: 46530

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Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Protein Details

14. Uncharacterized protein ygfH

General function:: Involved in catalytic activity
Specific function:: Specific function unknown
Gene Name:: ygfH
Uniprot ID:: P52043
Molecular weight:: 53824

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Propanoyl-CoA + succinate = propionate + succinyl-CoA.

Succinyl-CoA (ECMDB01022) (M2MDB000228)

Structure for #<Compound:0xa591daac>

Enzymes

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