Uridine diphosphate-N-acetylglucosamine (ECMDB00290) (M2MDB000120)

General function:

Involved in hydrolase activity

Specific function:

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell

Gene Name:

ushA

Uniprot ID:

P07024

Molecular weight:

60824

Reactions

General function:

Involved in transferase activity

Specific function:

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

Gene Name:

lpxA

Uniprot ID:

P0A722

Molecular weight:

28080

Reactions

General function:

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups

Specific function:

Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin

Gene Name:

murA

Uniprot ID:

P0A749

Molecular weight:

44817

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis and an acceptor for the addition of subsequent sugars to complete the biosynthesis of O-antigen. The apparent affinity of WecA for the polyisoprenyl phosphate substrates increases with the polyisoprenyl chain length. WecA is unable to utilize dolichyl phosphate (Dol-P)

Gene Name:

wecA

Uniprot ID:

P0AC78

Molecular weight:

40957

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

Gene Name:

glmU

Uniprot ID:

P0ACC7

Molecular weight:

49190

Reactions

General function:

Involved in undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity

Specific function:

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)

Gene Name:

murG

Uniprot ID:

P17443

Molecular weight:

37815

Reactions

General function:

Involved in UDP-N-acetylglucosamine 2-epimerase activity

Specific function:

Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption

Gene Name:

wecB

Uniprot ID:

P27828

Molecular weight:

42244

Reactions

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS

Gene Name:

waaU

Uniprot ID:

P27242

Molecular weight:

41729

Reactions

General function:

Involved in fatty acid biosynthetic process

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Name:

acpP

Uniprot ID:

P0A6A8

Molecular weight:

8640