L-Threonine (ECMDB00167) (M2MDB000068)

General function:

Involved in catalytic activity

Specific function:

Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction

Gene Name:

thrC

Uniprot ID:

P00934

Molecular weight:

47113

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent

Gene Name:

ilvA

Uniprot ID:

P04968

Molecular weight:

56195

Reactions

General function:

Involved in zinc ion binding

Specific function:

L-threonine + NAD(+) = L-2-amino-3- oxobutanoate + NADH

Gene Name:

tdh

Uniprot ID:

P07913

Molecular weight:

37239

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Uniprot ID:

P0A825

Molecular weight:

45316

Reactions

General function:

Involved in nucleotide binding

Specific function:

ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA

Gene Name:

thrS

Uniprot ID:

P0A8M3

Molecular weight:

74014

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Uniprot ID:

P0AE22

Molecular weight:

26103

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase

Gene Name:

tdcB

Uniprot ID:

P0AGF6

Molecular weight:

35232

Reactions

General function:

Involved in lyase activity

Specific function:

Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates

Gene Name:

ltaE

Uniprot ID:

P75823

Molecular weight:

36494

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livH

Uniprot ID:

P0AEX7

Molecular weight:

32982

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livM

Uniprot ID:

P22729

Molecular weight:

46269

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livG

Uniprot ID:

P0A9S7

Molecular weight:

28427

General function:

Involved in amino acid transport

Specific function:

This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids

Gene Name:

livJ

Uniprot ID:

P0AD96

Molecular weight:

39076

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livF

Uniprot ID:

P22731

Molecular weight:

26310

General function:

threonylcarbamoyladenosine biosynthetic process

Specific function:

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.

Gene Name:

tsaC

Uniprot ID:

P45748

Molecular weight:

20767

Reactions