2.02015-09-08 20:12:37 -06002015-09-14 11:20:15 -0600ECMDB24829M2MDB006946DG(19:iso/12:0(3-OH)/0:0)DG(19:iso/12:0(3-OH)/0:0) belongs to the family of Diacylglycerols. These are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. DG(19:iso/12:0(3-OH)/0:0) is also a substrate of diacylglycerol kinase. It is involved in the phospholipid metabolic pathway.C34H66O6570.896570.4859398453-hydroxy-2-[(3-hydroxydodecanoyl)oxy]propyl 17-methyloctadecanoate3-hydroxy-2-[(3-hydroxydodecanoyl)oxy]propyl 17-methyloctadecanoateCCCCCCCCCC(O)CC(=O)OC(CO)COC(=O)CCCCCCCCCCCCCCCC(C)CInChI=1S/C34H66O6/c1-4-5-6-7-15-19-22-25-31(36)27-34(38)40-32(28-35)29-39-33(37)26-23-20-17-14-12-10-8-9-11-13-16-18-21-24-30(2)3/h30-32,35-36H,4-29H2,1-3H3MWCSSXUEHTVEMA-UHFFFAOYSA-Nlogp8.78logs-6.98solubility5.94e-05 g/llogp10.17pka_strongest_acidic14.44pka_strongest_basic-2.8iupac3-hydroxy-2-[(3-hydroxydodecanoyl)oxy]propyl 17-methyloctadecanoateaverage_mass570.896mono_mass570.485939845smilesCCCCCCCCCC(O)CC(=O)OC(CO)COC(=O)CCCCCCCCCCCCCCCC(C)CformulaC34H66O6inchiInChI=1S/C34H66O6/c1-4-5-6-7-15-19-22-25-31(36)27-34(38)40-32(28-35)29-39-33(37)26-23-20-17-14-12-10-8-9-11-13-16-18-21-24-30(2)3/h30-32,35-36H,4-29H2,1-3H3inchikeyMWCSSXUEHTVEMA-UHFFFAOYSA-Npolar_surface_area93.06refractivity164.56polarizability74.41rotatable_bond_count32acceptor_count4donor_count2physiological_charge0formal_charge0phospholipid biosynthesis (CL(19:iso/12:0(3-OH)/12:0/12:0))Phospholipids are membrane components in E. coli.
The major phospholipids of E. coli are phosphatidylethanolamine, phosphatidylglycerol and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty acids at the sn-1 and sn-2 positions.
The reaction starts from a glycerone phosphate (dihydroxyacetone phosphate) produced in glycolysis. The glycerone phosphate is transformed to a sn-glycerol 3-phosphate (glycerol 3 phosphate) by NADPH driven glycerol-3-phosphate dehydrogenase.
Sn-glycerol 3-phosphate is transformed to a 1-acyl-sn-glycerol 3-phosphate(1-oleyl-2-lyso-phosphatidate , 1-palmitoylglycerol 3-phosphate , 1-stearoyl-sn-glycerol 3-phosphate). This can be achieve by a sn-glycerol-3-phosphate 1-0-acyltransferase that interacts either with a long-chain acyl-CoA or with an acyl-[acp]. The 1-acyl-sn-glycerol 3-phosphate is transformed into a 1,2-diacyl-sn-glycerol 3-phosphate through a 1-acylglycerol-3-phosphate O-acyltransferase.
This compound is then converted into a CPD-diacylglycerol through a CTP (phosphatidate cytididyltransferase. CPD-diacylglycerol can be transformed either to a L-1-phosphatidylserine or a L-1-phosphatidylglycerol-phosphate through a phosphatidylserine synthase or a phosphatidylglycerophosphate synthase respectively. The L-1-phosphatidylserine transforms into L-1-phosphatidylethanolamine through a phosphatidylserine decarboxylase, o the other hand L-1-phosphatidylglycerol-phosphate gets transformed into a L-1-phosphatidyl-glycerol through a phosphatidylglycerophosphatase. These 2 products combines produce a cardiolipin and a ethanolamine.
The L-1 phosphatidyl-glycerol can also interact with cardiolipin synthase resulting in a glycerol and a cardiolipin.
PW001999Metabolicphospholipid biosynthesis (CL(19:iso/12:0(3-OH)/19:iso/12:0(3-OH)))Phospholipids are membrane components in E. coli.
The major phospholipids of E. coli are phosphatidylethanolamine, phosphatidylglycerol and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty acids at the sn-1 and sn-2 positions.
The reaction starts from a glycerone phosphate (dihydroxyacetone phosphate) produced in glycolysis. The glycerone phosphate is transformed to a sn-glycerol 3-phosphate (glycerol 3 phosphate) by NADPH driven glycerol-3-phosphate dehydrogenase.
Sn-glycerol 3-phosphate is transformed to a 1-acyl-sn-glycerol 3-phosphate(1-oleyl-2-lyso-phosphatidate , 1-palmitoylglycerol 3-phosphate , 1-stearoyl-sn-glycerol 3-phosphate). This can be achieve by a sn-glycerol-3-phosphate 1-0-acyltransferase that interacts either with a long-chain acyl-CoA or with an acyl-[acp]. The 1-acyl-sn-glycerol 3-phosphate is transformed into a 1,2-diacyl-sn-glycerol 3-phosphate through a 1-acylglycerol-3-phosphate O-acyltransferase.
This compound is then converted into a CPD-diacylglycerol through a CTP (phosphatidate cytididyltransferase. CPD-diacylglycerol can be transformed either to a L-1-phosphatidylserine or a L-1-phosphatidylglycerol-phosphate through a phosphatidylserine synthase or a phosphatidylglycerophosphate synthase respectively. The L-1-phosphatidylserine transforms into L-1-phosphatidylethanolamine through a phosphatidylserine decarboxylase, o the other hand L-1-phosphatidylglycerol-phosphate gets transformed into a L-1-phosphatidyl-glycerol through a phosphatidylglycerophosphatase. These 2 products combines produce a cardiolipin and a ethanolamine.
The L-1 phosphatidyl-glycerol can also interact with cardiolipin synthase resulting in a glycerol and a cardiolipin.
PW002000MetabolicSpecdb::CMs1088291Specdb::NmrOneD265948Specdb::NmrOneD265949Specdb::NmrOneD265950Specdb::NmrOneD265951Specdb::NmrOneD265952Specdb::NmrOneD265953Specdb::NmrOneD265954Specdb::NmrOneD265955Specdb::NmrOneD265956Specdb::NmrOneD265957Specdb::NmrOneD265958Specdb::NmrOneD265959Specdb::NmrOneD265960Specdb::NmrOneD265961Specdb::NmrOneD265962Specdb::NmrOneD265963Specdb::NmrOneD265964Specdb::NmrOneD265965Specdb::NmrOneD265966Specdb::NmrOneD265967Specdb::MsMs27884Specdb::MsMs27885Specdb::MsMs27886Specdb::MsMs34442Specdb::MsMs34443Specdb::MsMs34444Yurtsever D. (2007). Fatty acid methyl ester profiling of Enterococcus and Esherichia coli for microbial source tracking. M.sc. Thesis. Villanova University: U.S.APhosphatidate cytidylyltransferaseP0ABG1CDSA_ECOLIcdsAhttp://ecmdb.ca/proteins/P0ABG1.xml2 DG(19:iso/12:0(3-OH)/0:0) + Cytidine triphosphate + Hydrogen ion >2 CDP-DG(19:iso/12:0(3-OH)) + PyrophosphatePW_R005629