2.02015-09-08 20:10:36 -06002015-12-09 14:08:52 -0700ECMDB24805M2MDB006922DG(17:0cycw7c/14:0/0:0)DG(17:0cycw7c/14:0/0:0) belongs to the family of Diacylglycerols. These are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. DG(17:0cycw7c/14:0/0:0) is also a substrate of diacylglycerol kinase. It is involved in the phospholipid metabolic pathway.C34H64O5552.881552.475375161(2R)-3-{[8-(2-hexylcyclopropyl)octanoyl]oxy}-2-hydroxypropyl tetradecanoate(2R)-3-{[8-(2-hexylcyclopropyl)octanoyl]oxy}-2-hydroxypropyl tetradecanoate[H][C@@](O)(COC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCC1CC1CCCCCCInChI=1S/C34H64O5/c1-3-5-7-9-10-11-12-13-14-17-21-25-33(36)38-28-32(35)29-39-34(37)26-22-18-15-16-20-24-31-27-30(31)23-19-8-6-4-2/h30-32,35H,3-29H2,1-2H3/t30?,31?,32-/m1/s1DVQZMPRJZQQRSZ-DQZOQLMQSA-Nlogp9.63logs-7.39solubility2.26e-05 g/llogp10.78pka_strongest_acidic13.63pka_strongest_basic-3.4iupac(2R)-3-{[8-(2-hexylcyclopropyl)octanoyl]oxy}-2-hydroxypropyl tetradecanoateaverage_mass552.881mono_mass552.475375161smiles[H][C@@](O)(COC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCC1CC1CCCCCCformulaC34H64O5inchiInChI=1S/C34H64O5/c1-3-5-7-9-10-11-12-13-14-17-21-25-33(36)38-28-32(35)29-39-34(37)26-22-18-15-16-20-24-31-27-30(31)23-19-8-6-4-2/h30-32,35H,3-29H2,1-2H3/t30?,31?,32-/m1/s1inchikeyDVQZMPRJZQQRSZ-DQZOQLMQSA-Npolar_surface_area72.83refractivity161.19polarizability71.82rotatable_bond_count31acceptor_count3donor_count1physiological_charge0formal_charge0phospholipid biosynthesis CL(15:0cyclo/17:0cycw7c/17:0cycw7c/14:0)"Phospholipids are membrane components in E. coli.
The major phospholipids of E. coli are phosphatidylethanolamine, phosphatidylglycerol and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty acids at the sn-1 and sn-2 positions.
The reaction starts from a glycerone phosphate (dihydroxyacetone phosphate) produced in glycolysis. The glycerone phosphate is transformed to a sn-glycerol 3-phosphate (glycerol 3 phosphate) by NADPH driven glycerol-3-phosphate dehydrogenase.
Sn-glycerol 3-phosphate is transformed to a 1-acyl-sn-glycerol 3-phosphate(1-oleyl-2-lyso-phosphatidate , 1-palmitoylglycerol 3-phosphate , 1-stearoyl-sn-glycerol 3-phosphate). This can be achieve by a sn-glycerol-3-phosphate 1-0-acyltransferase that interacts either with a long-chain acyl-CoA or with an acyl-[acp]. The 1-acyl-sn-glycerol 3-phosphate is transformed into a 1,2-diacyl-sn-glycerol 3-phosphate through a 1-acylglycerol-3-phosphate O-acyltransferase.
This compound is then converted into a CPD-diacylglycerol through a CTP (phosphatidate cytididyltransferase. CPD-diacylglycerol can be transformed either to a L-1-phosphatidylserine or a L-1-phosphatidylglycerol-phosphate through a phosphatidylserine synthase or a phosphatidylglycerophosphate synthase respectively. The L-1-phosphatidylserine transforms into L-1-phosphatidylethanolamine through a phosphatidylserine decarboxylase, o the other hand L-1-phosphatidylglycerol-phosphate gets transformed into a L-1-phosphatidyl-glycerol through a phosphatidylglycerophosphatase. These 2 products combines produce a cardiolipin and a ethanolamine.
The L-1 phosphatidyl-glycerol can also interact with cardiolipin synthase resulting in a glycerol and a cardiolipin."PW001149MetabolicSpecdb::CMs1088503Specdb::MsMs1268029Specdb::MsMs1268030Specdb::MsMs1268031Specdb::MsMs1383067Specdb::MsMs1383068Specdb::MsMs1383069Yurtsever D. (2007). Fatty acid methyl ester profiling of Enterococcus and Esherichia coli for microbial source tracking. M.sc. Thesis. Villanova University: U.S.APhosphatidate cytidylyltransferaseP0ABG1CDSA_ECOLIcdsAhttp://ecmdb.ca/proteins/P0ABG1.xmlDG(17:0cycw7c/14:0/0:0) + Cytidine triphosphate + Hydrogen ion > CDP-DG(17:0cycw7c/14:0) + PyrophosphatePW_R005699